Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

A surgical instrument for use with a robotic system that has a control unit and a shaft portion that includes an electrically conductive elongated member that is attached to a portion of the robotic system. The elongated member is configured to transmit control motions from the robotic system to an end effector.

An implantable device having a communication system, a sensor, and a monolithic substrate is described. The monolithic substrate has an integrated sensor circuit configured to process input from the sensor into a form conveyable by the communication system.

A continuous glucose monitoring system may utilize externally sourced information regarding the physiological state and ambient environment of its user for externally calibrating sensor glucose measurements. Externally sourced factory calibration information may be utilized, where the information is generated by comparing metrics obtained from the data used to generate the sensor's glucose sensing algorithm to similar data obtained from each batch of sensors to be used with the algorithm in the future. The output sensor glucose value of a glucose sensor may also be estimated by analytically optimizing input sensor signals to accurately correct for changes in sensitivity, run-in time, glucose current dips, and other variable sensor wear effects. Correction actors, fusion algorithms, EIS, and advanced ASICs may be used to implement the foregoing, thereby achieving the goal of improved accuracy and reliability without the need for blood-glucose calibration, and providing a calibration-free, or near calibration-free, sensor.

Implantable biosensors and methods of making and using such biosensors are disclosed. The biosensors can be micro-devices, for example, micro-sized bead implants having an associated gyroscope, accelerometer and/or magnetometer to detect and transmit changes in the position of the biosensor following implantation. The biosensors can be implanted into a subject’s bone and/or a subject’s prosthesis to detect, for example, changes in position or orientation of a prosthetic implant that can indicate loosening or potential onset of structural failures. Devices for implantation of biosensors, e.g., kinematic sensors, into bone are also disclosed as well as methods and systems for measuring or monitoring physiological kinematics.

An implantable sensor system using one or more sensor implants comprised of micro-electrical mechanical system (MEMS) sensors for the accurate and continuous measurement of physiological hemodynamic signals such as diastolic and systolic blood pressure. Sensor implants are configured to be subcutaneously injected to a placement site adjacent a blood vessel. In some embodiments, sensors comprise micromachined ultrasonic transducers.

The present relates, in general terms, to a device for monitoring oxidative stress in a sample, a method of making the device and a method of monitoring oxidative stress in a sample thereof.

An orthopedic system configured for use in a pre-operative, intra-operative, and post-operative assessment. The orthopedic system comprises a first screw, a second screw, a first device, a second device, and a computer. The first device and the second device are respectively coupled to a first bone and a second bone of a musculoskeletal system. The first and second devices each include electronic circuitry, one or more sensors, and an IMU. A bracket, wrap, or sleeve can be used to hold the first and second devices to the musculoskeletal system. The first and second devices are configured to send measurement data to a computer. The first and second devices each have an antenna system. Electronic circuitry in the first or second devices are configured to harvest energy from a received radio frequency signal to recharge a battery to maintain operation.

Techniques for acquiring and processing data in combination with a photonic sensor system-on-a-chip (SoC) (1) to provide real-time calibrated concentration levels of an analyte (e.g., a constituent molecule within a biological substance) are described. A raw signal (1300) to be analyzed is collected by the sensor chip (1) via diffuse reflectance or transmittance. Determination of the analyte concentration is based on, in part, Beer-Lambert principles and facilitated by applying (2240) scattering correction to the raw signal (1300) prior to decomposition and analysis thereof.

A wheeze detection device that allows suppressing a noise and improving detection accuracy of wheezing. The device includes a first microphone configured by a MEMS microphone, a space-forming member (a first housing, an O-ring, a flexible circuit board, and a second housing) forming an accommodation space that accommodates the first microphone, and a housing cover that forms a pressure receiving unit that closes the accommodation space and receives a pressure from a body surface. The space-forming member has a hole portion connected to an atmosphere. The accommodation space is connected to the atmosphere via the hole portion. The hole portion includes branch portions to between a groove and a terminal and two branched hole portions branched at each branch portion from a side of the groove. One branched hole portion among the two branched hole portions is connected to the terminal. The other branched hole portion is closed.