The present invention provides method for monitoring physiological status of an organ in a subject by monitoring morphological changes over time in transplanted tissue on an eye of the subject.

The present invention provides method for monitoring physiological status of an organ in a subject by monitoring morphological changes over time in transplanted tissue on an eye of the subject.

A microscopy imaging system comprises a fluorescence lifetime imaging microscopy (FLIM) system comprising a pulsed light source configured to direct a plurality of excitation light pulses onto a sample, a photo detector configured to detect emitted fluorescent photons created by the plurality of excitation pulses interacting with the sample, and a FLIM data acquisition system configured to measure the time interval between the excitation light pulses and the detected emitted fluorescent photons, a scanning light microscopy (SLM) system comprising a SLM data acquisition system, a fast scanning mirror and a slow scanning mirror, wherein the mirrors are configured to scan the light pulses across the sample; and a data processing system communicatively connected to the FLIM and SLM systems. Microscopy imaging methods are also disclosed.

A microscopy imaging system comprises a fluorescence lifetime imaging microscopy (FLIM) system comprising a pulsed light source configured to direct a plurality of excitation light pulses onto a sample, a photo detector configured to detect emitted fluorescent photons created by the plurality of excitation pulses interacting with the sample, and a FLIM data acquisition system configured to measure the time interval between the excitation light pulses and the detected emitted fluorescent photons, a scanning light microscopy (SLM) system comprising a SLM data acquisition system, a fast scanning mirror and a slow scanning mirror, wherein the mirrors are configured to scan the light pulses across the sample; and a data processing system communicatively connected to the FLIM and SLM systems. Microscopy imaging methods are also disclosed.

Examples relate to a surgical microscope system, and to a system, a method and a computer program for a surgical microscope system. The system comprises one or more processors and one or more storage devices. The system is configured to obtain intraoperative sensor data of at least a portion of an eye from a Doppler-based imaging sensor of the surgical microscope system. The system is configured to process the intraoperative sensor data to determine information on a blood flow within the eye. The system is configured to generate a visualization of the blood flow. The system is configured to provide a display signal to a display device of the surgical microscope system based on the visualization of the blood flow within the eye.

An ophthalmic apparatus includes an illumination optical system that generates slit-shaped illumination light using a first light source; an optical scanner that deflects the illumination light to a fundus of a subject's eye; an imaging optical system that captures light from the fundus using a rolling shutter method; an acquisition unit that acquires a fundus image of the subject's eye using light from a second light source; a flare determination unit that determines whether or not flare occurs by analyzing the fundus image; a controller that performs flare optimization control by controlling at least one of the first light source, the illumination optical system, the optical scanner, the imaging optical system, and the image sensor based on a first determination result obtained by the flare determination unit; and an image forming unit that forms an image of the fundus when the flare does not occur.

There is provided a medical image processing apparatus including: an association processing section configured to associate multiple medical captured images in which an observation target is imaged by each of multiple imaging devices including imaging devices in which one or both of an in-focus position and an in-focus range are different; and a compositing processing section configured to depth-composite each of a medical captured image for a right eye and a medical captured image for a left eye among the multiple medical captured images by using an associated other medical captured image.

An optical measurement apparatus includes a light source unit generating and outputting light, a polarized light generating unit generating polarized light from the light, an optical system generating a pupil image of a measurement target, using the polarized light, a self-interference generating unit generating multiple beams that are split from the pupil image, and a detecting unit detecting a self-interference image generated by interference of the multiple beams with each other.

Systems, devices, and methods for surgical illumination and imaging of ophthalmologic structures within a human eye are disclosed. In various embodiments, an emitter, imaging sensor, and a system control image processor are configured to irradiate ophthalmologic structures with near infrared light, detect near-infrared scatter from the irradiated ophthalmologic structures and visible light in real-time and generate or otherwise cause an image to be displayed on the user display that includes the detected near-infrared scatter from the irradiated ophthalmologic structures displayed in real-time. In one or more embodiments, the image is a virtual image of the irradiated ophthalmologic structures generated at least based on near-infrared light scattering coefficients of the irradiated ophthalmologic structures. In certain embodiments, the image displayed on the user display includes the detected near-infrared scatter from the irradiated ophthalmologic structures overlaid on a real-time view from a surgical microscope.

A system for visualizing a three-dimensional target area of an object with a measuring device which determines a distance of a surgical instrument in a target area with respect to a predetermined structure in the target area, a display unit for representing the views, and a control unit. The control unit controls the display unit such that the display unit is in a first display mode when a determined distance is greater than a predetermined first limit value, and switches from the first display mode into a second display mode when the determined distance changes from being greater than a predetermined second limit value, which is smaller than or equal to the predetermined first limit value, to smaller than the predetermined second limit value.