Disclosed herein are in vivo non-invasive methods and devices for the measurement of the hemodynamic parameters, such as blood pressure, cardiac output, stroke volume and vascular tone, of a subject, and the mechanical anelastic in vivo properties of the subject's arterial blood vessels. An exemplary method requires obtaining the peripheral pulse volume waveform (PVW), the peripheral pulse pressure waveform (PPW), and the peripheral pulse velocity waveform (PUW) from the same artery; calculating the time phase shift between the PPW and PVW, and the plot of pulse pressure versus pulse volume; and determining the blood pressures and power law components of the anelastic model from the waveforms PPW and PVW, the cardiac output from the waveforms PPW and PUW, and the quality factor of the artery based upon the calculations. The disclosed methods and devices can be used to diagnose and treat cardiovascular disease in a subject in need thereof.

The present application describes a Personal Hand-Held Monitor (PHHM) of the type described in WO 2013/002165, WO 2014/125431, and International Patent Application No. PCT/EP2015/079888, with improved aspects to find indicators of health, and other improvements that facilitate its construction and calibration.

An optical measurement device is provided with: a light source that irradiates, with light, a measurement object which has a fluid flowing thereinside; a light receiving unit which, upon receipt of scattered light from the measurement object irradiated with light, outputs a light reception signal according to the intensity of the scattered light; a disturbance generation unit which generates a disturbance signal for causing oscillation of a drive current to be supplied to the light source; and an adjustment unit which adjust the drive current on the basis of the result of a comparison between the disturbance signal and a signal generated on the basis of the light reception signal.

An optical measurement device is provided with: a light source that irradiates, with light, a measurement object which has a fluid flowing thereinside; a light receiving unit which, upon receipt of scattered light from the measurement object irradiated with light, outputs a light reception signal according to the intensity of the scattered light; a disturbance generation unit which generates a disturbance signal for causing oscillation of a drive current to be supplied to the light source; and an adjustment unit which adjust the drive current on the basis of the result of a comparison between the disturbance signal and a signal generated on the basis of the light reception signal.

A method measures a perfusion wave upstroke associated with leg perfusion dynamics, the perfusion wave upstroke including two phases, an initial slow phase and a fast-rising phase, and using prolongation of the slow phase to detect a presence of arterial stenosis and to assess stenosis severity.

A method measures a perfusion wave upstroke associated with leg perfusion dynamics, the perfusion wave upstroke including two phases, an initial slow phase and a fast-rising phase, and using prolongation of the slow phase to detect a presence of arterial stenosis and to assess stenosis severity.

A micro impulse radar (MIR) system includes an MIR transceiver circuit configured to transmit, towards a subject, at least one transmitted radar signal, and receive at least one radar return signal. The system includes a control circuit configured to generate a control signal defining a radar signal parameter of the at least one transmitted radar signal, provide the control signal to the MIR transceiver circuit to cause the MIR transceiver circuit to transmit the at least one transmitted signal based on the radar signal parameter, and determine, based on the at least one radar return signal, a physiological parameter of the subject.

A micro impulse radar (MIR) system includes an MIR transceiver circuit configured to transmit, towards a subject, at least one transmitted radar signal, and receive at least one radar return signal. The system includes a control circuit configured to generate a control signal defining a radar signal parameter of the at least one transmitted radar signal, provide the control signal to the MIR transceiver circuit to cause the MIR transceiver circuit to transmit the at least one transmitted signal based on the radar signal parameter, and determine, based on the at least one radar return signal, a physiological parameter of the subject.

An apparatus for estimating bio-information according to an embodiment includes: a sensor that measures a pulse wave signal from an object and contact pressure of the object; and a processor that obtains an oscillometric envelope based on an amplitude of the pulse wave signal and the contact pressure, and estimates bio-information based on a center of mass of a phase of contact pressure of the obtained oscillometric envelope.

An apparatus for estimating bio-information according to an embodiment includes: a sensor that measures a pulse wave signal from an object and contact pressure of the object; and a processor that obtains an oscillometric envelope based on an amplitude of the pulse wave signal and the contact pressure, and estimates bio-information based on a center of mass of a phase of contact pressure of the obtained oscillometric envelope.