A medical system for minimally-invasive measurement of blood flow in an artery (AT). An interventional device (IVD) with an optical fiber (FB) comprising a plurality of temperature-sensitive optical sensor segments, e.g. Fiber Bragg Gratings, spatially distributed along its longitudinal extension is configured for insertion into an artery (AT). A temperature changer (TC) is arranged in the WD to introduce a local change in temperature (ΔT) of a bolus of blood in the artery, to allow thermal tracking over time with the optical fiber (FB). A measurement unit (MU) with a laser light source (LS) delivers light to the optical fiber (FB) and receives light reflected from the optical fiber (FB) and generates a corresponding time varying output signal. A first algorithm (A1) translates this time varying output signal into a set of temperatures corresponding to temperatures at respective positions along the optical fiber (FB). A second algorithm (A2) calculates a measure of blood flow (BF) at respective positions along the optical fiber (FB) in accordance with a temporal behavior of said set of temperatures. Such system can be used to quickly scan an artery for diagnosing stenotic regions without the need for pullbacks or injection of toxic liquids. A good spatial resolution of the blood flow measurement can be obtained in real-time.

A system and method for inductive heating applications includes positioning one or more inductive heating elements in a location, delivering electromagnetic radiation, by a radiation source, to heat at least a portion of the one or more inductive heating elements, and detecting, by a detector, the heat generated by the one or more inductive heating elements. The system and method also include controlling, by a processing unit, a condition based on the detected heat.

A system and method for inductive heating applications includes positioning one or more inductive heating elements in a location, delivering electromagnetic radiation, by a radiation source, to heat at least a portion of the one or more inductive heating elements, and detecting, by a detector, the heat generated by the one or more inductive heating elements. The system and method also include controlling, by a processing unit, a condition based on the detected heat.

A heart failure marker that is simple, and preferably usable by non-invasive test. A method for measuring heart failure risk, comprising: (A) measuring an angiotensinogen amount value of urine collected from a subject.

A method of determining a local cerebrospinal fluid flow rate. The method including the steps of positioning a distal end of the catheter in a flow of cerebrospinal fluid of the patient, the catheter including an infusion port and at least one temperature sensor positioned at a fixed distance from the infusion port, infusing a bolus of a temperature controlled fluid through the infusion port into the flow of cerebrospinal fluid, and monitoring a temperature sensed by the at least one temperature sensor, wherein a change in the temperature sensed by the at least one temperature sensor over time is representative of a local cerebrospinal fluid flow rate in proximity to the infusion port.

A system includes an outer catheter and an inner catheter. The outer catheter has a proximal end and a distal end. The distal end has a discharge nozzle, a tapered interior wall, and an end orifice. The proximal end is configured to receive a fluid. The discharge nozzle is coupled to the proximal end by a first lumen. The discharge nozzle is configured to direct the fluid in a plurality of discrete streams aligned in a radial fashion about an axis of the first lumen. The interior catheter is configured for placement within the first lumen. A first end of the interior catheter includes an occluder and includes a first temperature sensor. The first temperature sensor is configured to pass through the end orifice. The occluder is configured to engage with the tapered interior wall in a fluid-tight seal. The first temperature sensor includes a sense surface and includes a signal node. The signal node is configured to provide a first signal corresponding to a timewise change in temperature at the sense surface.

A system includes an outer catheter and an inner catheter. The outer catheter has a proximal end and a distal end. The distal end has a discharge nozzle, a tapered interior wall, and an end orifice. The proximal end is configured to receive a fluid. The discharge nozzle is coupled to the proximal end by a first lumen. The discharge nozzle is configured to direct the fluid in a plurality of discrete streams aligned in a radial fashion about an axis of the first lumen. The interior catheter is configured for placement within the first lumen. A first end of the interior catheter includes an occluder and includes a first temperature sensor. The first temperature sensor is configured to pass through the end orifice. The occluder is configured to engage with the tapered interior wall in a fluid-tight seal. The first temperature sensor includes a sense surface and includes a signal node. The signal node is configured to provide a first signal corresponding to a timewise change in temperature at the sense surface.

Catheter systems and methods for determining blood flow rates based on light reflection measurements. The catheter may include a lumen extending between a proximal end of the catheter and a distal end of the catheter. The catheter may include fluid infusion openings at the distal end region of the catheter that are configured to permit the indicator fluid to exit the catheter from the lumen. The catheter system may include an optical fiber having one or more sensors thereon for sensing light reflected by blood particles in a body vessel lumen. A blood flow rate may be determined based on the sensed light reflected by blood particles in the body vessel lumen.

A system and method for inductive heating applications includes positioning one or more inductive heating elements in a location, delivering electromagnetic radiation, by a radiation source, to heat at least a portion of the one or more inductive heating elements, and detecting, by a detector, the heat generated by the one or more inductive heating elements. The system and method also include controlling, by a processing unit, a condition based on the detected heat.

A system and method for inductive heating applications includes positioning one or more inductive heating elements in a location, delivering electromagnetic radiation, by a radiation source, to heat at least a portion of the one or more inductive heating elements, and detecting, by a detector, the heat generated by the one or more inductive heating elements. The system and method also include controlling, by a processing unit, a condition based on the detected heat.