A biological fluid collection device (10) that receives a sample (12) and provides flow-through blood stabilization technology and a precise sample dispensing function for point-of-care and near patient testing applications is disclosed. A biological fluid collection device of the present disclosure is able to effectuate distributed mixing of a sample stabilizer within a blood sample and dispense the stabilized sample in a controlled manner. In this manner, a biological fluid collection device of the present disclosure enables blood micro-sample management, e.g., passive mixing with a sample stabilizer and controlled dispensing, for point-of-care and near patient testing applications. Advantageously, a biological fluid collection device of the present disclosure includes an internal vacuum (28). In this manner, a biological fluid collection device of the present disclosure eliminates the need for additional vacuum creating components that must be connected to the biological fluid collection device during use.

Devices and methods for withdrawing bodily fluid from a patient are disclosed herein. A handheld device configured in accordance with the present technology can include a housing having an opening, a skin-piercing assembly located at least partially within the housing, and an actuator movable relative to the housing along a deployment direction. The skin-piercing assembly can include a skin-piercing feature and a biasing member. The biasing member can be coupled to the skin-piercing feature to bias the skin-piercing feature along the deployment direction. Movement of the actuator along the deployment direction to a predetermined position can increase a load on the biasing member to at least a partially loaded state. Movement of the actuator along the deployment direction beyond the predetermined position can release the load on the biasing member so that the biasing member actively drives the skin-piercing feature along the deployment direction.

A catheter extension set may include a distal end, which may include a luer adapter configured to couple to a catheter adapter. The catheter extension may also include a proximal end, which may include a blood collection device. The blood collection device may include a needle configured to receive a blood collection container. The catheter extension may include one or more extension tubes extending between the distal end and the proximal end. The catheter extension set may increase flow resistance, which may reduce a risk of hemolysis when there is a high-pressure differential within the catheter extension set. After a pressure differential within the catheter extension set is lowered, the catheter extension set may decrease flow resistance, which may facilitate more rapid blood collection.

A device for collecting a liquid sample by capillarity includes distinct first and second elements having respective male and female parts. The male part comprises a channel having a transverse section. The female part comprises a peripheral wall that transversely delimits a cavity to house the male part. A part of the peripheral wall forms a cap to close the transverse section when the female part houses the male part.

A vacuum tube receiver can include a housing that has a proximal end and a distal end. The housing can include a hollow interior and a proximal opening for receiving a vacuum tube into the hollow interior. The distal end of the housing can form an adapter for coupling the vacuum tube receiver to an intravenous system. The vacuum tube receiver may also include one or more spikes that extend proximally into the hollow interior to form a blood flow path. The vacuum tube receiver can include a number of features to control the pressure and/or flowrate of blood into a vacuum tube.

An analyzing device has one end of a supplying capillary channel opened at a spot application section formed so as to protrude from an analyzing device main body. The supplying capillary channel is connected to a microchannel structure formed inside the analyzing device main body. A sample liquid is applied to the spot application section and is suctioned by a capillary force of the supplying capillary channel. The analyzing device is used for reading in which a suctioned solution is accessed. The analyzing device includes a leading end of the spot application section that has an inclined face. The end of the supplying capillary channel is opened on the inclined face.

An apparatus useful for the rapid collection of blood from a subject (e.g., a blood vessel, such as the vein, artery or capillary bed of a bovine subject) and dispensing the blood therefrom into a test or collection device. In general, the apparatus comprises: (a) a body having a chamber formed therein, said chamber having an inlet and outlet, with said chamber configured to draw blood therein; (b) a hollow barrel connected to said chamber outlet; (c) an ejector operatively associated with said barrel; (d) a hollow needle connected to said body, with said hollow needle in fluid communication with said chamber through said inlet, so that blood can be rapidly drawn into said chamber through said needle. The needle is optionally removed and blood dispensed from the body into a test or collection device by actuating the ejector.

A medical puncturing device having a wicking element disposed on a portion of the medical puncturing device is disclosed. The wicking element allows a user to remove a first drop of blood upon puncturing the skin using the medical puncturing device. In this manner, a subsequent drop of blood can be used to test their blood to determine their blood glucose level for proper insulin dosing.

Microfluidic devices are provided for continuous sampling of biological fluid for extended periods of time, e.g. for periods of time up to and including 10 days. The microfluidic devices can be made from porous hydrophilic substrate, e.g. hydrophilic paper substrates. The devices can include a collection pad, an evaporative pump, and a channel connecting the collection pad and the evaporative pump. Hydrogels at the collection pad can promote collection of sweat or other biological fluids from a subject, which in some aspects is assisted by the use of one or more microneedles on the substrate. An evaporative pump can provide for long periods of sampling by providing continual pumping, e.g. through the use of an evaporation pad where sampled fluid can evaporate.

Methods and apparatus for blood sampling from skin capillaries are provided. Blood extraction is improved by applying gradient pressure in a proximal to distal direction of an extremity. Blood is extracted and sampled from the skin capillaries with a blood sampling mechanism of at least a lancet and testing kit.