The disclosure describes devices and methods for providing transdermal electrical stimulation therapy to a subject including positioning a stimulator electrode over a glabrous skin surface overlying a palm of the subject and delivering electrical stimulation via a pulse generator transdermally through the glabrous skin surface and to a target nerve or tissue within the hand to stimulate the target nerve or tissue within the hand so that pain felt by the subject is mitigated. The pulses generated during the electrical stimulation therapy may include pulses of two different magnitudes.

A processing subsystem generates perceived images from information bearing nerve impulses that are transmitted from a subject's eye(s) to a visual processing region of the subject's brain along one or more nerves in response to the subject viewing a real-world scene. The processing subsystem generates display images based on the perceived images, and controls a display device to display the display images to the subject. In certain embodiments, the processing subsystem generates the display images by manipulating or modifying the perceived images to include virtual images, and provides a type of virtual pointing on the display images that is used to invoke one or more actions.

The present disclosure provides compositions which may be used as tissue engineering materials, and more particularly xylitol-doped citrate polymer compositions which may be useful as bone grafts.

A method for titrating a stimulation parameter for one or more electrode contacts in a system for stimulating a hypoglossal nerve of a patient includes activating one of the one or more electrode contacts to stimulate the hypoglossal nerve of the patient, obtaining a first and/or second physiological measurement from the patient, comparing the first and/or second physiological measurement to a first and/or second predetermined target value, adjusting a stimulation parameter for the one of the one or more electrode contacts if the first and/or second physiological measurement differs from the first and/or second predetermined target value.

The disclosure describes devices and methods for providing transdermal electrical stimulation therapy to a subject including positioning a stimulator electrode over a glabrous skin surface overlying a palm of the subject and delivering electrical stimulation via a pulse generator transdermally through the glabrous skin surface and to a target nerve or tissue within the hand to stimulate the target nerve or tissue within the hand so that pain felt by the subject is mitigated. The pulses generated during the electrical stimulation therapy may include pulses of two different magnitudes.

Disclosed herein are of systems, methods, and computer-program products for determining if a response is an electrically evoked compound action potential (eCAP), refining raw data of an eCAP amplitude growth function (AGF) and utilizing maximum (i.e., steepest) slope from moving linear regression to effectively estimate cochlear nerve function, and determining quality of an electrode-neuron interface (ENI) using a model developed from eCAP attributes.

A processing subsystem generates perceived images from information bearing nerve impulses that are transmitted from a subject's eye(s) to a visual processing region of the subject's brain along one or more nerves in response to the subject viewing a real-world scene. The processing subsystem generates display images based on the perceived images, and controls a display device to display the display images to the subject. In certain embodiments, the processing subsystem generates the display images by manipulating or modifying the perceived images to include virtual images, and provides a type of virtual pointing on the display images that is used to invoke one or more actions.

A system may include neuromodulation electrode contacts, a waveform generator, and a controller. The neuromodulation electrode contacts may be configured and arranged for use in delivering neuromodulation to a target peripheral nerve, where the target peripheral nerve includes a plurality of fibers, and the plurality of neuromodulation electrode contacts is configurable into a plurality of electrode configurations for stimulating different subsets of fibers within the plurality of fibers. The waveform generator may be configured for use to generate neuromodulation energy. The controller may be configured for use for identifying an electrode configuration that, when used to deliver the neuromodulation, stimulates fibers from an inhibitory surround receptive field, identifying a threshold amplitude corresponding to either a perception threshold or an evoked neural threshold for the identified electrode configuration, and delivering sub-perception therapy for the identified electrode configuration using a therapeutic amplitude that is set based on the threshold amplitude.

A system for remote motor and sensory function testing may involve use of patent and clinician computing devices, a patient testing device, and a clinician control device. A Remote Testing System (RTS) may coordinate displays of information among the devices in support of a test. A clinician or the RTS may cause display of instructions for guiding a patient in using the patient testing device. A clinician may receive feedback from the patient's interaction during the test session, or during a later session. The clinician control device may be used to control functioning of the patient testing device, in support of the test. The clinician control device may provide haptic or other feedback during the test session or during a later session. The system may track patient performance across multiple sessions and initiate follow-up test sessions as a result of data gathered in one or more prior test sessions.

Example systems and techniques for denervation, for example, renal denervation. In some examples, a processor determines one or more tissue characteristics of tissue proximate a target nerve and a blood vessel. The processor may generate, based on the one or more tissue characteristics, an estimated volume of influence of denervation therapy delivered by a therapy delivery device disposed within the blood vessel. The processor may generate a graphical user interface including a graphical representation of the tissue proximate the target nerve and the blood vessel and a graphical representation of the estimated volume of influence.