Systems and methods for providing a universal platform for at-home health testing and diagnostics are provided herein. In particular, a health testing and diagnostic platform is provided to connect medical providers with patients and to generate a unique, private testing environment. In some embodiments, the testing environment may facilitate administration of a medical test to a patient with the guidance of a proctor. In some embodiments, the patient may be provided with step-by-step instructions for test administration by the proctor within a testing environment. The platform may display unique, dynamic testing interfaces to the patient and proctor to ensure proper testing protocols and accurate test result verification.

The present invention is an adjustment means for a mandibular advancement device. The mandibular advancement device being of the type having both intraoral and extraoral portions, including a body portion that is at the interface between the intraoral and extraoral portions and thereby is part intraoral and part extraoral. The extraoral portion includes a lower arm that is substantially straight and extends directly outwardly from the extraoral part of the body portion, and a curved upper arm that curves upwardly from the lower arm and back towards the face of a person using the device. The posterior end of the upper arm includes a pad assembly that is adapted to make contact with, and apply pressure to, the subnasal maxillary bone of the wearer. A substantial portion of the lower arm is engageable with motorised means that are encapsulated within the body portion and are adapted to engage with the lower arm and cause it to slide further out of, or slidably retract further into, the body portion.

Apparatus is provided that includes left-nostril, right-nostril, and oral pressure sensors and oral pressure probes. A memory is configured to store left-nostril, right-nostril, and oral pressures sensed by the respective sensors, over a total period of at least 12 hours. A processor is configured to convert the left-nostril, right-nostril, and oral pressures stored in the memory to left-nostril, right-nostril, and oral pressure airflows, respectively, and calculate a series of orally-weighted laterality-indices over a respective series of sub-periods of the total period. Each of the orally-weighted laterality-indices of each of the sub-periods is indicative of a laterality index over the sub-period weighted by a normalized oral airflow over the sub-period, such that the greater the normalized oral airflow, the smaller the orally-weighted laterality-index. Each of the orally-weighted laterality-indices of each of the sub-periods reflects relative airflow through the left and the right nostrils over the sub-period. Other embodiments are also described.

A method and system are disclosed for use in monitoring/screening/diagnosing sleep or wake state of a subject or patient. The method generally includes monitoring the patient's activity during one or more sleep sessions comprising a plurality of intervals known as epochs. The sleep/wake state of the subject is determined during each epoch of the session using actigraphy data obtained during the monitoring session. The actigraphy data provides information about the activity of a patient during an epoch. The sleep or wake state is determined based on a ratio of the activity count during an epoch to the activity count during a preceding epoch. If the ratio is greater than a first activity threshold, then a “wake” indication may be provided by, for example, the system. Alternatively, or additionally, a “wake” indication may be determined if the activity count during the epoch is greater than a threshold.

A patient tracking device for insertion into an oral cavity includes a sensor housing comprising a first surface shaped to correspond to a pallet within the oral cavity. At least a portion of the first surface affixes the sensor housing to the oral cavity. An electromagnetic sensor is coupled to the sensor housing.

The invention comprises a method for estimating state of a cardiovascular system, comprising the steps of: providing a cardiac analyzer, comprising: a blood pressure sensor, the blood pressure sensor generating a time-varying pressure state waveform output from a portion of a person; a system processor connected to the blood pressure sensor; and a dynamic state-space model of a cardiovascular system, the system processor receiving cardiovascular input data, from the blood pressure sensor, related to a transient pressure state of the cardiovascular system, where at least one probabilistic model, of the dynamic state-space model, operating on the time-varying pressure state waveform output generates a probability distribution function to a non-pressure state of the cardiovascular system. The probability distribution function is iteratively updated using synchronized updated time-varying pressure state waveform output from the blood pressure sensor and a non-pressure state output related to a cardiovascular system parameter is generated.

A method of manufacturing a patient interface for sealed delivery of a flow of air at a continuously positive pressure with respect to ambient air pressure to an entrance to the patient's airways includes collecting anthropometric data of a patient's face. Anticipated considerations are identified from the collected anthropometric data during use of the patient interface. The collected anthropometric data is processed to provide a transformed data set based on the anticipated considerations, the transformed data set corresponding to at least one customised patient interface component. At least one patient interface component is modeled based on the transformed data set.

A patient monitor can noninvasively measure a physiological parameter using sensor data from a nose sensor configured to be secured to a nose of the patient. The nose sensor can include an emitter and a detector. The detector is configured to generate a signal when detecting light attenuated by the nose tissue of the patient. An output measurement of the physiological parameter can be determined based on the signals generated by the detector. The nose sensor can include an inner prong and an outer prong to assist the nose sensor in securing to a patient's nose. The detector can be coupled to an inner post of the inner prong and can be configured to secure to an interior or exterior portion of the patient's nose.

A wearable device may include a sensor. The sensor may include a flexible fabric, a conjugated polymer coating deposited on the fabric via vapor-phase oxidative chemical vapor deposition (oCVD), and a plurality of electrodes in coupled to the conjugated polymer coating. The wearable device may further include a processor communicatively coupled to the electrodes. The processor may measure an electrical property across the electrodes, determine a physiological event based on the measured electrical property, and output measurement information corresponding the physiological event.

A method for detecting wheeze from an audio respiratory signal comprises capturing the audio respiratory signal from a subject using a microphone. Further, the method comprises recognizing a plurality of breath cycles and a plurality of breath phases from the audio respiratory signal and detecting wheezing from the plurality of breath cycles and the plurality of breath phases. The detecting comprises analyzing a block of interest in the audio respiratory signal, wherein the block of interest comprises a plurality of frames. The detecting further comprises calculating an auto-correlation function (ACF) for each frame in the block and determining a maximum value of the ACF calculated for each frame in the block. Finally, the detecting comprises analyzing the maximum value to detect if wheezing is present in the block.