The present invention relates to a method for producing complex reality three-dimensional images and a system for same, the method comprising: (a) a step for determining first reality three-dimensional spatial coordinates for a three-dimensional image of a human body; (b) a step for determining second reality three-dimensional spacial coordinates for an image of an item of medical equipment; (c) a step for obtaining a three-dimensional image of the area surrounding the medical equipment, from an imaging means in the medical equipment, and determining third reality three-dimensional spatial coordinates for said image; (d) a step for examining an image that is at the same coordinates in the three kinds of three-dimensional spatial coordinates; and (e) a step for producing a complex reality three-dimensional image by selecting the one image that is at the same coordinates, if there is one image at the same coordinates, or selecting the necessary image or images from among a plurality of images, if there are multiple images at the same coordinates.

A system for ablating or monitoring a zone of the heart, includes a system to measure the heart electrical activity; a phased array for generating a beam of focussed ultrasound signals on a targeted zone of the heart; an imaging system determining an image of a transcostal wall projected in an image plane of the phased array by taking into consideration a position and direction of the phased array and making it possible to deactivate elements of the phased array in accordance with the position of the elements with regard to the position of the projected image of the transcostal wall; a positioning system to control the position of a focussed zone of a beam of focussed ultrasound signals on the targeted zone, a monitoring system to measure a temperature and tissue deformation in the targeted zone; and a device for measuring a level of cavitation in the targeted zone.

A registration fixture or plate is configured for use with a medical imaging system. The registration fixture may be an optical magnetic registration plate including a plurality of fiducial markers in arranged in a predefined unique pattern. The pattern can be unambiguously detected on 2D image of the plate produced by the medical imaging system. Association of the 2D imaged pattern of fiducial markers with the actual 3D pattern on the optical magnetic registration plate allows for accurate calculation of projection matrices and co-registration of the 3D and 2D coordinate systems.

Methods and systems are disclosed for radiating a moving object. The method may comprise acquiring a plurality of indicators of the phase of a physiological cycle of a patient and a plurality of images of the patient that include a target. Each image may be taken at a different phase of the physiological cycle and may be registered to the phase at which the image was taken. The method may also include identifying the target in each of the plurality of images, calculating a dose of radiation required to treat the target, calculating the number, orientation, and dwell time of one or more radiation beams required to deliver the calculated required dose of radiation to the target, and calculating a position of each of the one or more radiation beams required to achieve the calculated orientation. Each position may be a function of the phase of the physiological cycle to which each of the plurality of images is registered.

Methods and systems are provided for adaptive scan control. In one embodiment, a method includes, upon an injection of a contrast agent, processing acquired projection data of a monitoring area of a subject to measure a contrast signal of the contrast agent, estimating two or more target times of the contrast agent at the monitoring area of the subject based on the contrast signal, and carrying out a contrast scan that includes a two or more acquisitions each performed at a respective target time.

A computing system (118) includes a computer readable storage medium (122) with computer executable instructions (124), including a biophysical simulator (126) and an electrocardiogram signal analyzer (128). The computing system further includes a processor (120) configured to execute the electrocardiogram signal analyzer determine myocardial infarction characteristics from an input electrocardiogram and to execute the biophysical simulator to simulate a fractional flow reserve or an instant wave-free ratio index from input cardiac image data and the determined myocardial infarction characteristics.

Methods are provided for dynamically visualizing information in image data of an object of interest of a patient, which include an offline phase and an online phase. In the offline phase, first image data of the object of interest acquired with a contrast agent is obtained with an interventional device is present in the first image data. The first image data is used to generate a plurality of roadmaps of the object of interest. A plurality of reference locations of the device in the first image data is determined, wherein the plurality of reference locations correspond to the plurality of roadmaps. In the online phase, live image data of the object of interest acquired without a contrast agent is obtained with the device present in the live image data, and a roadmap is selected from the plurality of roadmaps. A location of the device in the live image data is determined. The reference location of the device corresponding to the selected roadmap and the location of the device in the live image data is used to transform the selected roadmap to generate a dynamic roadmap of the object of interest. A visual representation of the dynamic roadmap is overlaid on the live image data for display. In embodiments, the first image data of the offline phase covers different of phases of the cardiac cycle of the patient, and the plurality of roadmaps generated in the offline phase covers the different phases of the patient's cardiac cycle. Related systems and program storage devices are also described and claimed.

Methods and systems are provided for cardiac computed tomography imaging. In one embodiment, a method comprises reconstructing an image from projection data acquired during a scan with a reconstruction time determined based on a model relating a timing of an event to be imaged to a heart rate measured during the scan. In this way, the timing of a reconstruction may be consistently applied for a series of reconstructions, thereby inherently registering the reconstructions.

Systems and methods are disclosed for simulating microvascular networks from a vascular tree model to simulate tissue perfusion under various physiological conditions to guide diagnosis or treatment for cardiovascular disease. One method includes: receiving a patient-specific vascular model of a patient's anatomy, including a vascular network; receiving a patient-specific target tissue model in which a blood supply may be estimated; receiving joint prior information associated with the vascular model and the target tissue model; receiving data related to one or more perfusion characteristics of the target tissue; determining one or more associations between the vascular network of the patient-specific vascular model and one or more perfusion characteristics of the target tissue using the joint prior information; and outputting a vascular tree model that extends to perfusion regions in the target tissue, using the determined associations between the vascular network and the perfusion characteristics.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.