Adult autologous stem cells cultured on a porous, three-dimensional tissue scaffold-implant for bone regeneration by the use of a hyaluronan and/or dexamethasone to accelerate bone healing alone or in combination with recombinant growth factors or transfected osteogenic genes. The scaffold-implant may be machined into a custom-shaped three-dimensional cell culture system for support of cell growth, reservoir for peptides, recombinant growth factors, cytokines and antineoplastic drugs in the presence of a hyaluronan and/or dexamethasone alone or in combination with growth factors or transfected osteogenic genes, to be assembled ex vivo in a tissue incubator for implantation into bone tissue.

Provided is a joint replacement with a joint socket (10) having a concave joint surface (11), and with a joint insert (20) having a concave joint surface (21) and a convex joint surface (22) which are each delimited by a peripheral edge (23, 24). The convex joint surface (22) of the joint insert (20) is designed, in the assembled state, to form a first partial joint with the concave joint surface (11) of the joint socket (10). Moreover, the concave joint surface (21) of the joint insert (20) is designed, in the assembled state, to form a second partial joint with the convex joint surface (32) of a joint head (30). The joint socket (10) and the joint insert (20) each have a securing means (12, 25, 26) for preventing dislocation of the joint replacement.

A tunable implant, system, and method enables a tunable implant to be adjusted within a patient. The tunable implant includes a securing mechanism to secure the implant in the patient, a actuation portion that enables the implant to move and an adjustment portion that permits adjustment of the implant after the implant has been positioned within the patient. The method of adjusting the tunable implant includes analyzing the operation of the implant, determining if any adjustments are necessary and adjusting the implant to improve implant performance. The implant system includes both the tunable implant and a telemetric system that is operable to telemetrically receive data from the tunable implant where the data is used to determine if adjustment of the tunable implant is necessary. The system also includes an instrument assembly that is used for performing spinal surgery where the instrument assembly includes a mounting platform and a jig.

A tunable implant, system, and method enables a tunable implant to be adjusted within a patient. The tunable implant includes a securing mechanism to secure the implant in the patient, a actuation portion that enables the implant to move and an adjustment portion that permits adjustment of the implant after the implant has been positioned within the patient. The method of adjusting the tunable implant includes analyzing the operation of the implant, determining if any adjustments are necessary and adjusting the implant to improve implant performance. The implant system includes both the tunable implant and a telemetric system that is operable to telemetrically receive data from the tunable implant where the data is used to determine if adjustment of the tunable implant is necessary. The system also includes an instrument assembly that is used for performing spinal surgery where the instrument assembly includes a mounting platform and a jig.

Disclosed is a surgical targeting device for assisting placement of an elongated guidance member in a bone. The targeting device comprises a bottom portion having a dome-shaped convex outer surface and comprising a guidance through-hole extending along a guidance through-hole central axis for receiving the guidance member. A top portion of the targeting device is configured to be gripped by a tool. Further, a surgical system is disclosed which comprises the surgical targeting device.

A revision-implant receiver (18) is provided for supporting an implant (20) of a revision joint replacement (10). The revision-implant receiver (18) comprises a first receiver element (22) and a second receiver element (24). The first receiver element (22) and the second receiver element (24) are engaged with each other via a hinge element (26).

The present invention includes a hip-off-loading device including a pelvic assembly including a pelvic base plate configured for attachment to a human pelvis; a distraction adjustment mechanism coupled to the pelvic base plate, wherein the distraction adjustment mechanism is lockable, to provide for adjusting the distal distraction of the hip-off-loading device; and at least a portion of a rotation mechanism to provide for internal or external rotation or both, and to provide for non-dynamic interoperative adjustment of abduction, adduction, or both; a link movably coupled to the pelvic assembly to provide for internal or external rotation or both; and a femoral assembly coupled to the link and including a femoral attachment mechanism for attachment to a femur to provide for flexion, extension, or both.

The present invention includes a hip-off-loading device including a pelvic assembly including a pelvic base plate configured for attachment to a human pelvis; a distraction adjustment mechanism coupled to the pelvic base plate, wherein the distraction adjustment mechanism is lockable, to provide for adjusting the distal distraction of the hip-off-loading device; and at least a portion of a rotation mechanism to provide for internal or external rotation or both, and to provide for non-dynamic interoperative adjustment of abduction, adduction, or both; a link movably coupled to the pelvic assembly to provide for internal or external rotation or both; and a femoral assembly coupled to the link and including a femoral attachment mechanism for attachment to a femur to provide for flexion, extension, or both.

The present invention discloses a connected structure of a porous surface structure and a substrate, a method for preparing the same, and a prosthesis of the same. The connected structure consists of a pre-connected or integrally formed composite body of a porous surface structure and an intermediate; and a substrate, which is connected to said intermediate to achieve the connection of said composite body to the said substrate; the composite body comprising a first composite region corresponding to a first stiffness; a remaining composite region in the composite body other than the first composite region, which at least contains a second composite region corresponding to a second stiffness; and the first stiffness is less than the second stiffness. The present invention achieves a fastened connection between the composite and the substrate and largely maintains the mechanical properties of the substrate; and it provides a prosthesis with excellent bone ingrowth properties and that the strength of the substrate is not substantially affected.

A medical device for treating hip joint osteoarthritis in a human patient by providing at least one artificial hip joint surface. The medical device comprises a prosthetic part or a bone plug adapted to be placed in a hole in the pelvic bone and a supporting member connected to said prosthetic part or bone plug, wherein the prosthetic part or the bone plug is adapted to be inserted into said hole from the abdominal side of the acetabulum and oriented, during the insertion, such that the concave interior surface is facing in the direction towards the caput femur. Wherein the medical device comprises an artificial caput femur surface or artificial acetabulum surface, and wherein a largest cross-sectional distance of said artificial caput femur or acetabulum surface is smaller than said hole, such that said artificial caput femur surface can pass through said hole.