The present disclosure provides a system of gender specific pharmaceuticals. The system includes a first package of a pharmaceutical for use by a male and a second package of a pharmaceutical for use by a female. The first package includes at least one male dosage having a first dosage amount, an insert positioned in the first package, the insert including a recommended male dosage and a recommended female dosage that is different than the male dosage, and a male label coupled to the first package, the label including a male gender specifier. The female package includes at least one female dosage having a second dosage amount that is smaller than the first dosage amount, an insert positioned in the first package, the insert including a recommended male dosage and a recommended female dosage that is different than the male dosage, and a female label coupled to the second package, the female label including a female gender specifier, wherein the female gender specifier is different than the male gender specifier.

The disclosure includes a method for providing prosthetic implants for a total knee replacement procedure. This method includes receiving data representative of a knee joint of a patient and determining anatomical parameters from the received data. The method also includes creating a graphical model of the knee joint based on the determined anatomical parameters, and providing a femoral component of a knee joint implant based on at least one of the determined anatomical parameters and the graphical femoral portion. This method also includes providing at least one cutting instrument configured to facilitate removing a portion of the femur of the patient based on at least one of determined anatomical parameters and the graphical model.

A method for controlling generation of biologically desirable voids in a composition placed in proximity to bone or other tissue in a patient by selecting at least one water-soluble inorganic material having a desired particle size and solubility, and mixing the water-soluble inorganic material with at least one poorly-water-soluble or biodegradable matrix material. The matrix material, after it is mixed with the water-soluble inorganic material, is placed into the patient in proximity to tissue so that the water-soluble inorganic material dissolves at a predetermined rate to generate biologically desirable voids in the matrix material into which bone or other tissue can then grow.

A method for controlling generation of biologically desirable voids in a composition placed in proximity to bone or other tissue in a patient by selecting at least one water-soluble inorganic material having a desired particle size and solubility, and mixing the water-soluble inorganic material with at least one poorly-water-soluble or biodegradable matrix material. The matrix material, after it is mixed with the water-soluble inorganic material, is placed into the patient in proximity to tissue so that the water-soluble inorganic material dissolves at a predetermined rate to generate biologically desirable voids in the matrix material into which bone or other tissue can then grow.

A system of prosthetic implants for a total knee replacement procedure is provided. The system includes a tibial component of a knee joint implant, a tibial insert configured to be positioned against the superior side of the platform of the tibial component, a first femoral component of a knee joint implant, and a second femoral component of a knee joint implant.