A medical device for implantation in a hip joint of a human patient, the natural hip joint having a ball shaped caput femur as the proximal part of the femoral bone with a convex hip joint surface towards the center of the hip joint and a bowl shaped acetabulum as part of the pelvic bone with a concave hip joint surface towards the center of the hip joint. The medical device comprising; an artificial caput femur, comprising a convex surface towards the center of the hip joint. The artificial convex caput femur is adapted to, when implanted: be fixated to the pelvic bone of the human patient, and be in movable connection with an artificial acetabulum surface fixated to the femoral bone of the patient, thereby forming a ball and socket joint. The medical device further comprises a fixation element comprising a fixation surface adapted to be in contact with the surface of the acetabulum and adapted to fixate the artificial convex caput femur to at least the acetabulum of the pelvic bone.

Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.

A method of treating a hip joint of a human patient using a pelvic drill comprising a driving member, a bone contacting and an operating device for operating said driving member. The method comprise the steps of creating a hole passing through the pelvic bone and into the hip joint of the human patient, and providing at least one hip joint surface to the hip joint, through said hole in the pelvic bone of the human patient. In one embodiment the method includes inserting a needle or tube like instrument into the patient's body for filling a part of the patient's body with gas and thereby expanding a cavity within the body.

Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.

A proposed treatment of arthrosis/osteoarthritis in a joint of a mammal or human patient involves deposing a liquid material on at least one damaged surface of the joint. To accomplish this, a reservoir (110) is provided, which holds a volume of a biocompatible material in liquid form outside of a body containing the joint (J) to be treated. A proximal end (P) of a tube-shaped instrument (120) is connected to the reservoir (110), and a distal end (D) of the instrument (120) is inserted into the joint (J). The liquid material is fed through the instrument (120) to the distal end (D) for deposition on the at least one damaged joint surface. The material is configured to assume a solid form under predefined conditions (e.g. when cooling off, or being exposed to a specific type of radiation). When the material has the solid form, it has a resistance to wear adapted to replace a worn out joint surface.

A prosthetic implant replaces hyaline cartilage in a synovial joint with a flexible polymer sliding surface, preferably of hydrogel, on a segmented support with an array of adjacent segments to which the hydrogel is molded. Adjacent segments are laterally and angularly displaceable permitting the implant to conform to rounded or irregular surfaces or to be rolled or folded for arthroscopic placement. Tension cables threaded through segments along a circuit can cinch segments together for stiffening the supporting layer and/or the cable can pull the implant against a bone surface. Adjacent segments can have inter-engaged structures. In some embodiments the segments are carried on a flexible foil or fibrous sheet.

Methods and devices for correcting wear pattern defects in joints. The methods and devices described herein allow for the restoration of correcting abnormal biomechanical loading conditions in a joint brought on by wear pattern defects, and also can, in embodiments, permit correction of proper kinematic movement.

Provided herein are biomimetic osteochondral implants that are generally useful for the at least partial resurfacing of damaged cartilage within a joint. The implants are constructed to have a modular, layered structure in which the physical properties (e.g., stiffness and lubricity) or dimensions of each layer can be adjusted (e.g., by using the appropriate material and controlling the thickness thereof) based on the anatomy to be replaced. For example, the material and or thicknesses of the layers can be selected to approximate the physical properties and/or dimensions of cartilage (and, optionally, chondral and subchondral bone). Also provided herein are methods of treatment involving the use of said biomimetic osteochondral implants to repair an osteochondral defect in a joint.

Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.

An implantable medical device, for implantation in a mammal knee joint, comprising an artificial contacting surface adapted to replace at least one contacting surface of the knee joint and to be lubricated when implanted in said joint. The medical device further comprises a reservoir comprising a movable wall portion defining the volume of the reservoir, at least one inlet adapted to receive a lubricating fluid from the reservoir, at least one channel at least partly integrated in said artificial contacting surface, wherein the channel is fluidly connected with said at least one inlet for distributing said lubricating fluid to the surface of said artificial contacting surface. The medical device further comprises an operation device adapted to non-invasively transport said lubricating fluid from said reservoir to said artificial contacting surface, and an implantable injection port for refilling said reservoir, wherein the movable wall portion is moved when the reservoir is refilled, such that the volume of the reservoir is increased.