A woven prosthesis, such as a woven vascular graft, woven from warp and weft yarns. Velour warp yarns forming the prosthesis are selectively incorporated into a base layer of the prosthesis so as to provide a bulbous section without compromising the porosity of the prosthesis.

Biodegradable magnesium alloy implantable medical devices are protected to delay onset of corrosion, and thus biodegradability, or to corrode more uniformly. The protection allows for extended effective use of the devices while maintaining biodegradability. Examples of protective coatings include conversion coatings that at least partially remove exposed second phases from a surface of the magnesium alloy and coatings that provide a barrier between water and the surface of the magnesium alloy.

In one embodiment according to the present invention, a stent is described having a generally cylindrical body formed from a single woven nitinol wire. The distal and proximal ends of the stent include a plurality of loops, some of which include marker members used for visualizing the position of the stent. In another embodiment, the previously described stent includes an inner flow diverting layer.

A medical implant delivery system is described. The system can be used to deliver a variety of implants including stents and/or stent grafts. The delivery system retains the implant during delivery and detaches the implant at a target location.

A sheet structure comprising two joined extracellular matrix (ECM) tissue or sheet layers and a physiological sensor disposed therebetween; the ECM tissue being derived from a mammalian tissue source that includes small intestine submucosa (SIS), urinary bladder submucosa (UBS), stomach submucosa (SS), urinary basement membrane (UBM), liver basement membrane (LBM), amniotic membrane, mesothelial tissue, placental tissue and cardiac tissue.

A prosthetic heart valve including a frame, leaflet structure, and sealing member disposed around an outer surface of the frame is disclosed. As one example, the sealing member includes an inner layer and a plush outer layer comprising a plush outer surface. The inner layer is arranged against the outer surface of the frame and the outer layer is arranged against and attached to the inner layer. The inner layer is folded over at inflow and outflow ends, in an axial direction relative to a central longitudinal axis of the frame, to overlap respective ends of the outer layer and form tapered folds at opposite ends of the sealing member, each tapered fold including a narrower, first portion where the inner layer folds over and contacts itself and a wider, second portion where the inner layer overlaps an outer surface of an end portion of the outer layer.

Some target anatomies within the ear, nose and/or throat of a patient may be difficult to access and treat. To provide a means of treating such target anatomies over time, drug delivery devices that are sized to be positioned within a naturally occurring or man-made anatomical cavity or passageway are preloaded with active agent(s). The drug delivery devices are affixed directly to, or in the vicinity of, a target anatomy. Once affixed, the drug delivery devices are configured to deliver active agent(s) at desired dosage(s) to the target anatomy through controlled elution of the active agent(s) as various structural features of the drug delivery devices are bio-eliminated.

A biomimetic tissue scaffold for repairing an elongated tissue in need of repair can comprise a plurality of coiled flexible polymeric ribbons having a surface on which is formed an array of nanofibers, the ribbons forming a tubular body defining a first open end in which a first end of the elongated tissue is receivable, a second open end in which a second end of the elongated tissue is receivable, and a lumen extending between the first and second open ends.

Intravascular inflatable medical devices and their methods of manufacture and use. The inflatable medical devices may include a conduit that includes an inflatable wall, with the inflatable wall defining a lumen therein. The inflatable wall may include an outer layer and an inner layer, and optionally an intermediate layer between the inner and layers. Intermediate layers may include one or more couplings between the outer and inner layers, and may include radial connectors extending between the outer layer and the inner layer.

A device for treating a diseased native valve in a patient includes a frame structure and a valve segment coupled to the frame structure. The frame structure has an unexpanded configuration and an expanded configuration. The valve segment has a plurality of leaflets, a seal, and a seal support. An inflow edge of the plurality of leaflets is unsupported by the frame structure. The seal is attached to the inflow edge of the plurality of leaflets and positioned radially between the frame structure and the plurality of leaflets. The seal support is attached to or within the seal and provides axial rigidity to the seal.