A prosthetic valve including a leaflet frame configured to be transitioned from a collapsed state having a first diameter to an expanded state having a second diameter that is larger than the first diameter. The leaflet frame has an inlet and outlet end and defining a longitudinal axis. The leaflet frame includes a plurality of frame members that form a framework defining plurality of cells each having an interior cell space, the plurality of cells including an attachment cell. The plurality of frame members includes a plurality of sub-cell attachment members extending into the interior cell space of the attachment cell, the sub-cell attachment members each being configured to define a plurality of attachment locations along a sub-cell attachment line defined within a plane that intersects with the longitudinal axis such that the sub-cell attachment line extends through the interior cell space of the at least one attachment cell.

An implant for therapeutically separating bones of a joint has two endplates each having an opening through the endplate, and at least one ramped surface on a side opposite a bone engaging side. A frame is slideably connected to the endplates to enable the endplates to move relative to each other at an angle with respect to the longitudinal axis of the implant, in sliding connection with the frame. An actuator screw is rotatably connected to the frame. A carriage forms an open area aligned with the openings in the endplates. The openings in the endplates pass through the carriage to form an unimpeded passage from bone to bone of the joint. The carriage has ramps which mate with the ramped surfaces of the endplates, wherein when the carriage is moved by rotation of the actuator screw, the endplates move closer or farther apart.

A nerve scaffold, including a membrane material and a degradable metal wire. The degradable metal wire is enclosed in the membrane material. The membrane material is biodegradable material, and includes three-dimensional pore structure. The degradable metal wire is horizontally and vertically distributed in the nerve scaffold.

Injectable bone graft material having a biocompatible, resorbable polymer and a biocompatible, resorbable inorganic material exhibiting macro, meso, and microporosities.

The embodiments provide a spinal implant that is configured for midline insertion into a patient's intervertebral disc space. The spinal implant may have a body and the body comprises one or more apertures. The apertures receive fixation elements, such as a screw and the like. The fixation element may comprise one or more anti-backout features, such as a split ring. In addition, at least some of the apertures are designed to permit a predetermined amount of nutation by a fixation element. The apertures that allow nutation enable the fixation element to toggle from one position to another, for example, during subsidence of the implant in situ. Some of the apertures may be configured to rigidly lock with the fixation elements. Moreover, the spinal implant may include features, such as one or more bores, that can accommodate imaging marks to help guide a surgeon.

Techniques and systems for distracting a spinal disc space and supporting adjacent vertebrae are provided. Trial instruments are insertable into the disc space to determine a desired disc space height and to select a corresponding implant. Implants can be also be self-distracting and the implant providing the desired disc space height can be implanted in the spinal disc space.

This invention is directed to an assembled implant comprising two or more portions of bone that are held together in appropriate juxtaposition with one or more biocompatible pins to form a graft unit. Preferably, the pins are cortical bone pins. Typically, the cortical pins are press-fitted into appropriately sized holes in the bone portions to achieve an interference fit. The bone portions are allograft or xenograft.

Medical devices suitable for implantation in spaces between bones are described. An example medical device suitable for use as an intervertebral spacer includes a main body having an exterior proximal wall, an exterior distal wall, a first exterior lateral wall, a second exterior lateral wall, an upper surface, a lower surface, an interior proximal wall, an interior distal wall, a first interior lateral wall, a second interior lateral wall, and a longitudinal axis. The interior proximal wall, the interior distal wall, the first interior lateral wall, and the second interior lateral wall cooperatively define an interior cavity. The first and second exterior lateral walls are outwardly directed at an angle from the lower surface to the upper surface relative to the longitudinal axis.

The present invention disclosed a method of producing a three-dimensional porous tissue in-growth structure. The method includes the steps of depositing a first layer of metal powder and scanning the first layer of metal powder with a laser beam to form a portion of a plurality of predetermined unit cells. Depositing at least one additional layer of metal powder onto a previous layer and repeating the step of scanning a laser beam for at least one of the additional layers in order to continuing forming the predetermined unit cells. The method further includes continuing the depositing and scanning steps to form a medical implant.

An implant for therapeutically separating bones of a joint has two endplates each having an opening through the endplate, and at least one ramped surface on a side opposite a bone engaging side. A frame is slideably connected to the endplates to enable the endplates to move relative to each other at an angle with respect to the longitudinal axis of the implant, in sliding connection with the frame. An actuator screw is rotatably connected to the frame. A carriage forms an open area aligned with the openings in the endplates. The openings in the endplates pass through the carriage to form an unimpeded passage from bone to bone of the joint. The carriage has ramps which mate with the ramped surfaces of the endplates, wherein when the carriage is moved by rotation of the actuator screw, the endplates move closer or farther apart.