A monitoring system includes: (1) an implant having at least one sensor and configured for at least partial insertion into a patient, a first one of sensors being in contact with a perimeter of a hole in a body portion of the implant for accepting a fastener; (2) a microchip associated with the implant and the sensor, the microchip configured to receive at least a first signal from the sensor; (3) a transmitter associated with the microchip for transmitting a second signal, representative of the first signal; (4) a receiver located outside of the patient, the receiver configured receive the transmitted second signal; and (5) a display device associated with the receiver, the display device configured to provide an audible or visual representation of the second signal to a user.

One embodiment of the present invention is directed to compositions and methods for enhancing attachment of soft tissues to a metal prosthetic device. In one embodiment a construct is provided comprising a metal implant having a porous metal region, wherein said porous region exhibits a nano-textured surface.

Vertebral body replacement apparatuses, systems, and methods are provided. In various examples, an implantable device is configured to be inserted between a first vertebral body and a second vertebral body. The implantable device includes a first endplate configured to contact a superior endplate of the first vertebral body. A central member is pivotably coupled to the first endplate. A second endplate is configured to contact an inferior endplate of the second vertebral body. The implantable device includes a first insertion configuration and a second load-bearing configuration. The first insertion configuration includes the central member at a first angular position with respect to the first endplate. The second load-bearing configuration includes the central member at a second angular position with respect to the first endplate and the second endplate in a load-bearing position.

A stent able to minimize occurrences of strain and stress concentration in a drug coat layer upon expansive deformation of the stent in a radial direction to avoid the possibility of the drug separating from the stent, includes a stent body and a drug coating layer coated on the outside surface of the stent body so that the thickness of the drug coating layer gradually decreases toward a bent portion of the stent.

Compositions including a surface or film comprising nanofibers, nanotubes or microwells comprising a bioactive agent for elution to the surrounding tissue upon placement of the composition in a subject are disclosed The compositions are useful in medical implants and methods of treating a patient in need of an implant, including orthopedic implants, dental implants, cardiovascular implants, neurological implants, neurovascular implants, gastrointestinal implants, muscular implants, and ocular implants.

A hip prosthesis includes an acetabular cup and a femoral component comprising a head and a stem, wherein the stem comprises a truss structure, the truss structure comprising a space truss comprising a plurality of planar truss units having a plurality of struts joined at nodes, wherein the web structure is configured to interface with bone tissue.

Disposable temporary spacer device for an articulation of the human body or for a bone cavity, wherein the spacer device includes at least one first component adapted to be constrained to a bone portion or end, wherein the spacer device is made from a biologically compatible material and comprises interconnected pores distributed in the entire volume occupied by the spacer device, in which the interconnected pores have a size and occupy a percentage of the volume of the spacer device such that it is able to absorb and consequently elute one or more pharmaceutical or medical substances in liquid or fluid form or in paste, cream, gel, wax, or viscous form.

This invention is directed to an assembled implant comprising two or more portions of bone that are held together in appropriate juxtaposition with one or more biocompatible pins to form a graft unit. Preferably, the pins are cortical bone pins. Typically, the cortical pins are press-fitted into appropriately sized holes in the bone portions to achieve an interference fit. The bone portions are allograft or xenograft.

A disposable device for absorbing urine and/or bodily fluids in the urethra having a cylindrical body about 4-8 mm in diameter by about 3-5 cm in length and having a top and bottom end. The body is made of absorbent material that expands upon contact with urine and bodily fluids and includes a string connected to the bottom end of the body for removing the device from the urethra. The device can be used to treat urinary incontinence and/or erectile dysfunction by inserting into the urethra and removing the device after it has been impregnated with fluid. The device can be included in a kit with a plunger for insertion.

The present disclosure provides for a medical device or a substrate coated with polydopamine which is further linked to ligands such as antibodies and/or antibody fragments. The polydopamine coating and the ligands may be linked through a linker such as an organic polymer.