A dispenser (1) of liquids for medical uses wherein a first membrane body (10) is shaped symmetrically with respect to a first frontal median plane (M) and to a second sagittal median plane (N) intersected in a central axis (A) and is delimited at the top by a dome (12) which is axially delimited by a base portion (12′) and by a top (12″) of given shape; a second body (20) being carried by the first body (10) inside the dome (12) in a position concentric with the axis (A); the second body (20) having a hollow lower portion (22) concentric with the axis (A) and an upper portion (28) engaged by a first and a second duct (280) (280′) terminating in the dome (12), with a first nozzle (2800′) (2800) and a second nozzle (2800′) respectively; each first and second nozzle (2800) (2800′) being arranged between the first frontal median plane (M) and the second sagittal median plane (N).

A dispenser (1) of liquids for medical uses wherein a first membrane body (10) is shaped symmetrically with respect to a first frontal median plane (M) and to a second sagittal median plane (N) intersected in a central axis (A) and is delimited at the top by a dome (12) which is axially delimited by a base portion (12′) and by a top (12″) of given shape; a second body (20) being carried by the first body (10) inside the dome (12) in a position concentric with the axis (A); the second body (20) having a hollow lower portion (22) concentric with the axis (A) and an upper portion (28) engaged by a first and a second duct (280) (280′) terminating in the dome (12), with a first nozzle (2800′) (2800) and a second nozzle (2800′) respectively; each first and second nozzle (2800) (2800′) being arranged between the first frontal median plane (M) and the second sagittal median plane (N).

The present invention relates to intranasal pharmaceutical compositions comprising cyclobenzaprine or salts thereof for the treatment or management of muscle spasms in musculoskeletal diseases and/or painful physical symptoms in neurological diseases. In particular, the invention relates to intranasal pharmaceutical compositions comprising cyclobenzaprine or salts thereof and one or more pharmaceutically acceptable excipients.

A nasal irrigation device communicates an irrigant to a device user and comprises a mechanics module and a reservoir assembly wherein a source of saline comprising a cartridge is disposed within the mechanics module adjacent a lid assembly for piercing the cartridge upon closing of a lid for releasing the cartridge contents into the reservoir assembly. A faux collapsible cartridge for testing operability of a nasal irrigation device comprises a housing including a shaft, a spring biased rod extending from the housing shaft, and a flange depending from a housing wall whereby the rod and flange are disposed to actuate a trigger assembly of the nasal irrigation device.

A nasal irrigation device communicates an irrigant to a device user and comprises a mechanics module and a reservoir assembly wherein a source of saline comprising a cartridge is disposed within the mechanics module adjacent a lid assembly for piercing the cartridge upon closing of a lid for releasing the cartridge contents into the reservoir assembly. A faux collapsible cartridge for testing operability of a nasal irrigation device comprises a housing including a shaft, a spring biased rod extending from the housing shaft, and a flange depending from a housing wall whereby the rod and flange are disposed to actuate a trigger assembly of the nasal irrigation device.

A method is provided that includes intranasally dispensing nasal wash fluid into a nasal cavity of a subject. Thereafter, a specimen sample is collected by performing an anterior nares nasal swab. The specimen sample is tested for the presence of a virus using a lateral flow immunoassay test strip. Other embodiments are also described.

A method is provided that includes intranasally dispensing nasal wash fluid into a nasal cavity of a subject. Thereafter, a specimen sample is collected by performing an anterior nares nasal swab. The specimen sample is tested for the presence of a virus using a lateral flow immunoassay test strip. Other embodiments are also described.

Systems and methods for nasal irrigation are provided in which a nasal irrigation device includes a source of saline solution, an effluent receptacle, a nasal interface, a vacuum source, a fluid passageway to communicate the source of saline solution with the effluent receptacle through the nasal interface and a nasal cavity of the user, and a switch and valve assembly for selectively controlling the vacuum source and flow of the saline solution through the fluid passageway. The saline solution source bottle is disposed relative to the device to provide gravitational inducement of saline solution to the nasal interface in engagement to the device user's nostrils. A combination of the gravitational inducement and the relative vacuum from an effluent receptacle generates a fluid flow for irrigating, cleansing and massaging the nasal cavity and ostia of a user. The entire device is assembled as a hand-held device for convenient lifting and disposal against the user's nostrils.

Systems and methods for nasal irrigation are provided in which a nasal irrigation device includes a source of saline solution, an effluent receptacle, a nasal interface, a vacuum source, a fluid passageway to communicate the source of saline solution with the effluent receptacle through the nasal interface and a nasal cavity of the user, and a switch and valve assembly for selectively controlling the vacuum source and flow of the saline solution through the fluid passageway. The saline solution source bottle is disposed relative to the device to provide gravitational inducement of saline solution to the nasal interface in engagement to the device user's nostrils. A combination of the gravitational inducement and the relative vacuum from an effluent receptacle generates a fluid flow for irrigating, cleansing and massaging the nasal cavity and ostia of a user. The entire device is assembled as a hand-held device for convenient lifting and disposal against the user's nostrils.

A method is provided that includes intranasally dispensing nasal wash fluid into a nasal cavity of a subject such that the nasal wash fluid washes biological material into an oropharynx of the subject from (a) the nasal cavity, (b) a nasopharynx of the subject, or (c) the nasal cavity and the nasopharynx. The method further includes, thereafter, collecting a specimen sample that passed out of an anterior opening of an oral cavity of the subject and contains at least a portion of the biological material washed into the oropharynx by the nasal wash fluid. Thereafter, information is derived from extracellular vesicles present in the specimen sample. Other embodiments are also described.