A fluid collection system comprises a sealed reagent container that fits inside a sample container and is unsealed by disengaging a seal comprised in a sample container. The sealed reagent container contains a reagent, such as a nucleic acid preservative. The reagent container also includes a sleeve disposed opposite the sealed opening. The sleeve includes a distal opening for receiving a sample and a proximal opening disposed in the sample container for guiding a sample from the distal opening and through the proximal opening into the sample container. Disengaging the seal releases the reagent into the sample container with the sample, where they mix.

There was still an unsatisfied need to have a device specifically adapted for the collection of sputum, for example from CF patients. This technical problem is overcome by the kit of the invention comprising a sterile sampling container having a gas-permeable cap, an anaerobic atmosphere generator, and a sealable pouch adapted to receive the sterile sampling container and the anaerobic atmosphere generator therein. This kit is easy to use, cost effective and makes the transport of the sample easy while the sample can be kept viable for several hours. Our in vitro tests show that the use of the kit improves the number of survival colonies by 3 log after 48 h for V. parvula and by 1 log after 24 h for S. aureus.

There was still an unsatisfied need to have a device specifically adapted for the collection of sputum, for example from CF patients. This technical problem is overcome by the kit of the invention comprising a sterile sampling container having a gas-permeable cap, an anaerobic atmosphere generator, and a sealable pouch adapted to receive the sterile sampling container and the anaerobic atmosphere generator therein. This kit is easy to use, cost effective and makes the transport of the sample easy while the sample can be kept viable for several hours. Our in vitro tests show that the use of the kit improves the number of survival colonies by 3 log after 48 h for V. parvula and by 1 log after 24 h for S. aureus.

A device for detecting postpartum hemorrhage is provided. A mat defines a proximal end and a distal end. The mat is configured to be disposed between a support and a patient and has a surface with a fluid flow region configured to direct flow of bodily fluids from the patient towards the distal end of the mat. A first detachable and optionally sealable bag is configured to receive the bodily fluids from the patient in a first operational mode of the device. A second sealable bag is configured to receive the bodily fluids from the patient in a second operational mode of the device. The second sealable bag comprises a visual volume indicator to measure the bodily fluids collected in the second sealable bag.

A device for detecting postpartum hemorrhage is provided. A mat defines a proximal end and a distal end. The mat is configured to be disposed between a support and a patient and has a surface with a fluid flow region configured to direct flow of bodily fluids from the patient towards the distal end of the mat. A first detachable and optionally sealable bag is configured to receive the bodily fluids from the patient in a first operational mode of the device. A second sealable bag is configured to receive the bodily fluids from the patient in a second operational mode of the device. The second sealable bag comprises a visual volume indicator to measure the bodily fluids collected in the second sealable bag.

An apparatus to preserve liquid from a medicine vial may include a vial coupling member forming a vial coupling member cavity and a container forming a cavity. The apparatus may further include a first fluid pathway forming a first lumen that is in fluid communication with the vial coupling member cavity and the cavity and a second fluid pathway forming a second lumen that is in fluid communication with the vial coupling member cavity and the cavity. The vial coupling member cavity, the cavity, the first lumen, and the second lumen may form a sterile environment that is sealed from contaminants in an ambient environment. The apparatus may include a disengaging member configured to permit the container to disengage from the first fluid pathway and the second fluid pathway while permanently sealing at least one of the first lumen or the second lumen.

Methods of accelerating the reconstitution of plasma powder by mixing the powder with small beads is disclosed. The beads can be, for example, glass and/or plastic resin beads having a diameter from about 2 mm to about 6 mm. The plasma powder can be, for example, a spray-dried plasma powder. A method is provided of accelerating the reconstitution of a dry protein powder in a fluid that includes, but is not limited to, the steps of providing both a dry protein powder and small beads in a container, adding a reconstitution fluid to the container, and manipulating the dry protein powder and the small beads to dissolve the dry protein powder in the reconstitution fluid.

Methods of accelerating the reconstitution of plasma powder by mixing the powder with small beads is disclosed. The beads can be, for example, glass and/or plastic resin beads having a diameter from about 2 mm to about 6 mm. The plasma powder can be, for example, a spray-dried plasma powder. A method is provided of accelerating the reconstitution of a dry protein powder in a fluid that includes, but is not limited to, the steps of providing both a dry protein powder and small beads in a container, adding a reconstitution fluid to the container, and manipulating the dry protein powder and the small beads to dissolve the dry protein powder in the reconstitution fluid.

A controlled environment enclosure comprises a robotic arm manipulation system used to protect and unprotect a fluid path and a swab within the controlled environment enclosure. The apparatus allows the fluid path to be protected against dangerous decontamination vapors and chemicals before the controlled environment enclosure is decontaminated. The apparatus allows the fluid path to be unprotected without the use of gloves or other means that degrade the integrity of the controlled environment enclosure when decontamination is completed. The apparatus and method allow for the protecting, unprotecting and decontaminating sequences to be automated. In some embodiments the fluid path comprises a fill needle that can removably and aseptically be sealed with a disposable monolithic injection moulded polymeric fill needle sheath. The apparatus and method further allow for the use of a swab disposed in a swab holder that is aseptically and removably sealable to a swab cap to protect the swab against decontamination vapors.

The present invention relates to a blood bag system, a method for its manufacture, and a process for reducing pathogens and leucocytes in biological fluids in particular in therapeutic quantities of platelet concentrates (PC) contained in the blood bag system, using UV-light and agitation, wherein part of the plasma of the PC is optionally exchanged against a platelet additive solution.