An N-acetylglucosamine sugar chain group-containing compound which can easily reach cells/sites on which a vimentin and/or desmin protein(s) is/are exposed, which compound has excellent affinity to N-acetylglucosamine sugar chain-recognizing proteins; a drug delivery carrier compound comprising the compound; a preparation using the drug delivery earner compound; and a drug delivery system; are provided. These are an N-acetylglucosamine sugar chain group-containing compound having a weight average molecular weight within the range of 15,000 to 100,000; a drug delivery carrier compound comprising the compound; a preparation using the drug delivery carrier compound; and a drug delivery system.

The present invention is directed to compositions and methods targeting cells in a subject harboring conditions or at risk for conditions that would benefit from gas-based diagnostic and therapy. The present invention relates to the use of fluorochemical compositions and methods of delivery that result in retention of the fluorochemical composition and any bioactive agent, including gaseous substances, delivered in combination with the fluorochemical composition.

The present invention relates to a multi-imaging contrast agent composition and a method for preparing same, in which the composition comprises a hydrogel formed by crosslinking a first dextran polymer and a second dextran polymer, wherein the hydrogel is loaded with a fluorescent dye and a contrast material. The composition comprises a dextran-based hydrogel in which a fat-soluble contrast material and a water-soluble fluorescent dye are simultaneously loaded, and has the advantage of enabling accurate localization of lung lesions.

The present invention relates to a nanocomposite for detecting hydrogen sulfide; a method for preparing the same; a novel reactive fluorogenic compound to be used in the method; a kit for detecting hydrogen sulfide comprising the nanocomposite; and a method for providing information for the diagnosis of a disease, which causes abnormal secretion of hydrogen sulfide, by using the nanocomposite.

Described herein are hybrid nanoparticles that are exosomes loaded with one or more nanoparticle dendrimers. Also included are pharmaceutical compositions including the hybrid nanoparticles and methods of making the hybrid nanoparticles. Also described is a method of treating a human subject by administering to the human subject the above-described hybrid nanoparticles.

Disclosed are folic acid or pteroic acid conjugates and methods for using such conjugates. The conjugates described herein comprise a chemotherapeutic drug or imaging agent covalently bound thereto through a bond or via a linker that is intracellularly disrupted by, e.g., endogenous enzymes such as esterases, lipases and the like so as to provide for the chemotherapeutic drug free of the folic or pteroic acid.

This present invention relates to the carbon nanotubes as composites with materials such as elastomers, thermosets and thermoplastics or aqueous dispersions of open-ended carbon nanotubes with additives. A further feature of this invention relates to the development of a concentrate of carbon nanotubes with an elastomer wherein the concentrate can be further diluted with an elastomer and other polymers and fillers using conventional melt mixing equipment.

An N-acetylglucosamine sugar chain group-containing compound which can easily reach cells/sites on which a vimentin and/or desmin protein(s) is/are exposed, which compound has excellent affinity to N-acetylglucosamine sugar chain-recognizing proteins; a drug delivery carrier compound comprising the compound: a preparation using the drug delivery earner compound; and a drug delivery system; are provided. These are an N-acetylglucosamine sugar chain group-containing compound having a weight average molecular weight within the range of 15,000 to 100,000; a drug delivery carrier compound comprising the compound; a preparation using the drug delivery carrier compound; and a drug delivery system.

The present invention is directed to compositions and methods targeting cells in a subject harboring conditions or at risk for conditions that would benefit from gas-based diagnostic and therapy. The present invention relates to the use of fluorochemical compositions and methods of delivery that result in retention of the fluorochemical composition and any bioactive agent, including gaseous substances, delivered in combination with the fluorochemical composition.

A composition comprising a plurality of particle clusters in a carrier, at least one particle cluster comprising a plurality of metal nanoparticles, wherein a configuration of the at least one particle cluster is such that the composition has an absorbance spectra peak of above about 900 nm. A method of making the composition comprising: reacting a metal nanoparticle precursor with a stabilizing agent to produce functionalized metal nanoparticles, dispersing the functionalized metal particles in a clustering agent to form the particle clusters; and re-suspending the particle clusters in a carrier to form the composition. Uses of the composition include as a contrast agent for imaging.