The invention concerns methods of delivering a hydrogel to the heart, comprising: introducing a hydrogel composition into a subject, said hydrogel comprising components mixed prior to introduction; the introducing being performed such that the hydrogel composition resides between the epicardium and the pericardium of the subject. In some embodiments, the injection is performed using a syringe or catheter.

Coaxial electrospinning is used to encapsulate a chitin-lignin based hybrid gel with polycaprolactone (PCL). Antibiotics and/or other bioactive agents loaded into the core and/or shell layer of the fibrous platform are released in a controlled and sustained manner that effectively inhibits both Gram-positive and Gram-negative bacteria without cytotoxicity to mammalian cells. The PCL shell layer provides longer life for the CL gels in a wet environment and allows sustainable drug release. The PCL-coated CL nanofiber scaffolds can be loaded with antimicrobial nanoparticles, antibiotics, oxygen-releasing agents, antioxidants and/or growth factors that promote healing when used as a controlled drug release dressing for chronic wounds, such as diabetic ulcers.

Compositions and implants for articular cartilage repair or regeneration are described. The compositions are hydrogel-based compositions that can incorporate signaling molecules for cartilage repair. The compositions include microcapsules having predetermined erosion profiles that are loaded with nanogels having predetermined sustained release profiles for signaling molecules conjugated to the nanogels. A plurality of compositions, each carrying different signaling molecules, can be layered to form a multi-layered implant, with each layer sequentially releasing the encapsulated signaling molecules over a predetermined period of time. The compositions can carry additional components to encourage tissue generation such as stem cells and extracellular matrix (ECM) components.

The invention relates to novel internal fixation devices, such as bone plates, generally and novel craniomaxillofacial bone plates more specifically and systems for bonding the same. More specifically, the invention relates to bone plates made of a polymer blend of (poly)lactic acid and Ecoflex as well as a novel hot-melt adhesive polymer blend of the same material.

A medical device includes a body defining an exterior surface, and a coating including a therapeutic agent-containing nanoparticle disposed on the exterior surface of the medical device. The nanoparticle may include a brush-arm star polymer. The therapeutic agent may be paclitaxel.

A medical device includes a body defining an exterior surface, and a coating including a therapeutic agent-containing nanoparticle disposed on the exterior surface of the medical device. The nanoparticle may include a brush-arm star polymer. The therapeutic agent may be paclitaxel.

The invention relates to a device comprising a surgical material and a support material and related methods for the application of the surgical material to a wound or surgical site using the device.

The present invention relates to a water-absorbing polymer and to a process for preparation, including finishing the water-absorbing polymer, with 0.0001 to 3% by weight, of a peroxo compound, based on the acrylic acid, after the polymerization is treated, and to a process for producing a hydrogel polymer, to the product of the process and to use.

An object of the present invention is to provide a cell-containing bioabsorbable tubular structure having molecular permeability, a device for manufacturing the tubular structure, and a method for manufacturing the tubular structure. According to the present invention, there is provided a tubular structure constituted with a cell structure which contains biocompatible polymer blocks and cells, in which the plurality of polymer blocks is disposed in voids between the plurality of cells.

An entirely or partially implantable medical product with a negatively charged surface for repulsing bacteria has a superficially bonded substance with a permanently negative excess charge, which substance is inert against cells of the human body and the bacteria contained therein.