A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. In certain aspects, annealing of the microgel particles occurs after exposure to an annealing agent that is endogenously present or exogenously added. In some embodiments, annealing of the microgel particles requires the presence of an initiator such as exposure to light. In particular embodiments, the chemical and physical properties of the gel building blocks can be controlled to allow downstream control of the resulting assembled scaffold. In one or more embodiments, cells are able to quickly infiltrate the interstitial spaces of the assembled scaffold.

A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. In certain aspects, annealing of the microgel particles occurs after exposure to an annealing agent that is endogenously present or exogenously added. In some embodiments, annealing of the microgel particles requires the presence of an initiator such as exposure to light. In particular embodiments, the chemical and physical properties of the gel building blocks can be controlled to allow downstream control of the resulting assembled scaffold. In one or more embodiments, cells are able to quickly infiltrate the interstitial spaces of the assembled scaffold.

A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. In certain aspects, annealing of the microgel particles occurs after exposure to an annealing agent that is endogenously present or exogenously added. In some embodiments, annealing of the microgel particles requires the presence of an initiator such as exposure to light. In particular embodiments, the chemical and physical properties of the gel building blocks can be controlled to allow downstream control of the resulting assembled scaffold. In one or more embodiments, cells are able to quickly infiltrate the interstitial spaces of the assembled scaffold.

A process of manufacturing a wound dressing filler and/or wound dressing.

Biologically activated ion-exchange polymer salts are made by exchanging biologically active ionic agents onto ion-exchange polymers. The activated polymers are uniquely surface active and stable to thermal degradation and chemical and other forms of decomposition. The activated ion-exchange polymer salts may be processed and combined with polymer precursors using novel methods and materials to produce stable, biologically activated polymer composites, including antimicrobial and antifouling polymer composites.

A composition and method of preparing the composition for rapid and effective hemostasis is provided. The composition includes a first agent to induce platelet plug formation, a second to induce vasoconstriction and a third agent for activation of coagulation cascade. The composition comprises of 0.01% to 5% of chitosan; 0.01% to 0.25% of potassium aluminum sulphate; and 0.01% to 0.25% calcium salt. The clotting time of the composition is in the range of 30s to 140s. A method of preparing the hemostatic composition is further disclosed. The composition is configured to control hemorrhage from oozing and pressured bleeding injury any site in human/animal body.

Wound repair materials and methods of using the same to inhibit excess fibrosis are disclosed.

Intermediate laminates and articles comprising a low adhesion backsize coating are described. The laminate comprises a substrate having a major surface and opposing surface and a coating comprising a block copolymer disposed on a major surface of the substrate wherein the block copolymer comprises a polyorganosiloxane block and a polyolefin block, the polyolefin block having a melt point of at least 110° C. Also described are medical dressings comprising such laminate.

An improved abdominal hernia repair system is presented comprised of a silicone layer backed up with a knitted or woven polypropylene fabric layer, the silicone layer possessing a regular pattern of slits that permit equilibration of fluid pressure across the device. A variety of therapeutic substances can be applied to the hernia repair device to promote healing, including aloe and other medicinal preparations. A layer of water soluble or water insoluble anti-scar compound is also present, the preferred compound being Salinomycin.

An improved inguinal hernia repair system is presented that is identical to the above except it does not contain the hydrophobic silicone component.

A medical adhesive and the preparation method, and application thereof. The medical adhesive is in the form of a gel, which contains a giant salamander skin mucus and an aqueous solution; the ratio parts by weight of the giant salamander skin dried powder and the aqueous solution is 1:1 to 1:6, and the weight content of the giant salamander skin mucus freeze-dried powder in the medical adhesive ranges from 14.2% to 50%. The present invention also provides the preparation method for preparing the aforementioned medical adhesive, and at the same time, the aforementioned medical adhesive is applied for the wound.