A fluid separation system and method includes a durable hardware component including a pump station with plurality of pumps, a centrifuge mounting station and drive unit, a plurality of valves and clamps, and a controller. The system includes a single use fluid flow circuit having a separation chamber configured to be received by the centrifuge and the fluid flow circuit is engageable with the durable hardware component to control fluid flow within the fluid flow circuit. The fluid flow circuit having an air access component configured to selectively receive air and to provide the air into a conduit to induce plug flow between the separated fluid component and another separated fluid component, wherein the controller is configured to operate the system to perform one or more blood processing procedures to convey a fluid into the separation chamber and to remove a separated fluid component from the separation chamber.

A modular cassette is provided for separating a composite fluid into at least two component parts thereof during centrifugation. The modular cassette includes: a housing defining a fluid inlet, a fluid outlet, and a chamber for fluid separation; a fluidic channel configured to provide fluid communication between at least two components of the modular cassette; a heat expanding valve including: a flow pathway including undulations configured to facilitate closing of the fluidic channel, wherein the heat expanding valve occludes one or more of the undulations of the flow pathway to close the fluidic channel; and a heating element configured to actuate the heat expanding valve.

A system and methodology for the preservation of red blood cells is described in which red blood cells are oxygen or oxygen and carbon dioxide depleted, treated and are stored in an anaerobic environment to optimize preparation for transfusion. More particularly, a system and method for extended storage of red blood cells from collection to transfusion that optimizes red blood cells prior to transfusion is described.

A variety of fill options is provided for a cell processing system. Certain options relate to a syringe assembly that receives a product directly from a separator. Other options relate to a filling system associated with the cell processing system, the filling system comprising one or more filling stations, each with at least one container, that receive product from a product container associated with the cell processing system.

A device comprising: (a) a housing; (b) one or more pumps located within the housing, the one or more pumps configured to create a negative pressure and move fluid; (c) one or more connectors located at least partially within in the housing; (d) internal fluid paths connecting the one or more pumps to the one or more connectors; (e) one or more reservoirs connected to the one or more connectors, the one or more reservoirs being configured to collect the fluid moved by the one or more pumps; and (f) a processor configured to:(i) calculate a total volume of fluid collected in the one or more reservoirs; and (ii) indicate that the one or more reservoirs are full; wherein the fluid moved is a fluid from a wound or incision.

A system and apparatus for the collection of serous or serosanguinous fluid from a percutaneous site after surgery. A pump unit with one or more pumps or powered sources provide continuous negative pressure suction to draw fluid from the percutaneous site and pumps the fluid into disposable reservoirs with one-way valves that are easy to handle while maintaining sterility and a seal to prevent the loss of vacuum. Air is continuously removed from the reservoirs. Measurement and analysis of the output is performed automatically.

A blood purification device includes a porous molded body containing an inorganic ion-adsorbing material and is characterized by the following: the concentrations of Mg, Al, Ti, V, Cr, Mn, Fe, Ni, Cu, Zn, Ga, Rb, Sr, Y, Zr, Mo, Ru, Ag, Cd, Sn, Cs, La, Pr, Sm, Gd, Tb, Ta, Au, Tl, Co, In, and Bi are each 0.1 ppb or less and the concentrations of Ba, Nd, Pb, And Ce are each 1 ppb or less in a physiological saline solution for injection both three months and six months after said physiological saline solution for injection is sealed in the blood purification device; and the number of fine particles having a size of 10 m or more is 25 or less and the number of fine particles having a size of 25 m or more is 3 or less in 1 mL of the physiological saline solution for injection.

Blood from a blood source is drawn into a fluid flow circuit. A mononuclear cell product is separated from the blood, followed by at least a portion of the mononuclear cell product being conveyed into an electroporation device without disconnecting the blood source from the fluid flow circuit. The electroporation device opens pores in a membrane of at least one of the cells of the mononuclear cell product to allow DNA material (which is added to the mononuclear cell product prior to electroporation) to enter and modify the genome of the cell. At least a portion of the modified mononuclear cell product is returned to the blood source. The mononuclear cell product may be washed prior to being conveyed into the electroporation device. The modified mononuclear cell product may be washed after exiting the electroporation device.

The method for the preparation of containment units of biological liquids, comprises the following stages of: furnishing a device (1) comprising a main body (2) which defines at least a continuous filling channel (3), having at least an inlet gap (3a) of a biological liquid and at least an air outlet gap (3b), a plurality of containment units (4) arranged in succession to one another so as to communicate with each other and defining respective containment chambers (5) positioned along the filling channel (3) and placed in between the inlet gap (3a) and the outlet gap (3b), a hydrophobic air filtering device (6) associated with the body (2) in correspondence to the outlet gap (3b), wherein the containment units (4) are bulbous members each having opposing elastically deformable sides that define the respective containment chambers therebetween, and wherein after deformation the sides return to a convex non-deformed idle configuration in which the sides are at a non-zero distance from one another; injecting a biological fluid along the channel (3) through the inlet opening (3a) so as to push towards outside the air contained inside the containment chambers (5) through the outlet gap (3b) and to gradually filling the containment chambers (5) which it crosses; closing and isolating the containment units (4) the one from the other.

Disclosed are methods, systems, and devices for removing cytokines and other substances from blood of a subject in a closed fluid circuit. The methods, systems, and devices involve: (i) passing venous blood from the subject through a plasma separator, thereby separating the blood into blood cells and plasma; (ii) passing the plasma received from the plasma separator through an adsorption chamber located in the circuit to form processed plasma, where materials in the adsorption chamber adsorb cytokines in the plasma to form the processed plasma, and where the materials include, by weight, 50-70% activated carbon and 30-50% non-ionic resin; (iii) combining the processed plasma, received directly from the adsorption chamber, with the blood cells in a combining chamber to form processed blood, without exchanging any of the plasma for another fluid; and (iv) transfusing the processed blood from the circuit directly into the subject, where no fluid besides the subject's blood is added to the circuit before the transfusing of the processed blood into the subject is completed.