The present disclosure describes intravascular oxygenation systems and methods with one or more of improved oxygen diffusion flux, improved resistance to bubble formation on the surface of non-porous hollow fibers, and reduced size. The systems and methods include a pneumatic inlet coupled to a pneumatic source that provides a gas containing oxygen at a high pressure. A plurality of hollow fiber membranes (HFM) are in pneumatic communication with the pneumatic inlet to receive the gas containing oxygen and with an outlet to exhaust a partially deoxygenated gas. An electronic controller drives the motor to oscillate the plurality of HFMs to cause a diffusive flux of the gas containing oxygen from the plurality of HFMs into a region of interest of a subject. The electronic controller may drive the motor according to an oscillation pattern, which may include a macro-oscillation with superimposed micro-oscillations.

An artificial kidney and its supportive device comprising a catheter having an internal semipermeable membrane tube to act as an artificial kidney. Said catheter comprising a proximal portion having a semipermeable membrane tube, a blood/infusion lumen, a dialysate lumen and side holes, while a distal portion having a dual septa port assembly. Said supportive device comprising a device house with its cover that covers its internal cavity that includes sorbent bags with different sizes and arrangement, a screen, buttons , set knobs, two contactless conductivity cells, bidirectional rotary pumps, rotary valves, pressure sensors, a slot for memory card, a temperature sensor, scales, an IV pole and a blood leak detector.

A method comprising: inserting the catheter having an internal semipermeable membrane tube that acts as artificial kidney into a suitable vein or artery, then using the supportive device to supporting, facilitating, and controlling the operation of the artificial kidney and to managing the dialysate inflow and outflow to and from the dialysate lumen within the catheter and also to managing the blood inflow and outflow to and from the infusate/blood lumen within the catheter to be on opposite direction across the semipermeable membrane of the artificial kidney.

The invention involves a unique, useful, novel and nonobvious device through which the blood of a patient afflicted with ARDS can have its O.sub.2 level augmented while reducing the CO.sub.2 level. This is achieved by disclosing a unique, useful, novel and nonobvious complex intravascular catheter which creates a system of intravascular, exo-pulmonary oxygenation of the blood.

Hemofilters for in vivo filtration of blood are disclosed. The hemofilters disclosed herein provide an optimal flow of blood through the filtration channels while maintaining a pressure gradient across the filtration channel walls to enhance filtration and minimize turbulence and stagnation of blood in the hemofilter.

Bioartificial ultrafiltration devices comprising a scaffold comprising a population of cells enclosed in a matrix and disposed adjacent a plurality of channels are provided. The population of cells provides molecules such as therapeutic molecules to a subject in need thereof and is supported by the nutrients filtered in an ultrafiltrate from the blood of the subject. The plurality of channels in the scaffold facilitate the transportation of the ultrafiltrate and exchange of molecules between the ultrafiltrate and the population of cells.

An implantable renal replacement therapy device may include: a first catheter configured to be inserted into a blood vessel in a subject's body; a pump in fluid communication with the first catheter, the pump is configured to pump subject's blood from the blood vessel; a filter in fluid communication with the pump, the filter is configured to: receive the subject's blood from the pump, and filter the received blood to provide a filtered blood and a filtrate liquid, wherein the filter is in fluid communication with the first catheter to cause an outflow of the filtered blood from the filter to the blood vessel; and a second catheter in fluid communication with the filter and configured to be inserted into an urinary bladder in the subject's body to cause an outflow of the filtrate liquid from the filter to the urinary bladder.

A hemodialysis device is described herein. An exemplary hemodialysis device includes an import tube, a dialysis tube, and an export tube. The dialysis tube includes an inner dialysis tube, a dialysis membrane and an outer dialysis tube. The inner dialysis tube is within the dialysis membrane, which is within the outer dialysis tube. An inlet and an outlet of the inner tube are disposed at a first end of the outer dialysis tube. The inlet of the inner dialysis tube is coupled to the import tube and the outlet of the inner dialysis tube is coupled to the export tube. The dialysis tube is inserted into an artery of a patient, and thereby performs hemodialysis within the body. Since the hemodialysis in performed within the artery instead of drawing blood out of the body, the hemodialysis device will minimally affect blood pressure, which is more economic and safe.

A device containing transplanted tissue includes a housing, having a chamber configured for insertion into a body of a subject and protecting the transplanted tissue from the subject's immune system. The housing includes an oxygen supply container, a hydrogel layer, a port, and an access port. The oxygen supply container has a chamber defined by top and bottom surfaces and sides, disposed within the chamber of the housing. The top surface and the bottom surface of the oxygen supply container include a gas-permeable membrane. The hydrogel layer has inner and outer surfaces. The inner surface of the hydrogel layer contacts the top surface of the oxygen supply container or the bottom surface of the oxygen supply container. The port is configured to deliver oxygen to the oxygen supply container. The access port is configured to receive an exogenous supply of gas and is fluidly connected to the port.

An array of hollow nanotubes is configured and dimensioned to allow impurities to transport through the hollow nanotubes from a first space containing an impurity-laden fluid to a second space where the impurities may be collected for removal, allowing fluids, such as blood, to be purified.

A hemofiltration device capable of surely performing highly-efficient hemofiltration. The hemofiltration device of the present invention is adapted to be implanted in a mammalian body for filtering blood, and includes a blood flow path layer having a blood flow path, a filtrate flow path layer having a filtrate flow path disposed along the blood flow path, and a filtration membrane interposed between the blood flow path layer and the filtrate flow path layer, for filtering the blood flowing through the blood flow path. A filtrate outlet of the filtrate flow path is provided at a position closer to a blood outlet than to a blood inlet of the blood flow path. The blood inlet, blood outlet, and filtrate outlet are provided only on one side or separately on opposite sides of a main body portion in the direction in which the layers are stacked.