A fluid handling cassette, such as that useable with an automated peritoneal dialysis (APD) cycler device or other infusion apparatus, may include a generally planar body having at least one pump chamber formed as a depression in a first side of the body and a plurality of flowpaths for a fluid that includes a channel. A patient line port may be arranged for connection to a patient line and be in fluid communication with the at least one pump chamber via at least a first one of said flowpaths, and an optional membrane may be attached to the first side of the body over the at least one pump chamber. In one embodiment, the membrane may have a pump chamber portion with an unstressed shape that generally conforms to the depression of the at least one pump chamber in the body and is arranged to be movable for movement of the fluid in a useable space of the at least one pump chamber. One or more spacers may be provided in the at least one pump chamber to prevent the membrane from contacting an inner wall of the at least one pump chamber. The patient line, a drain line, and/or a heater bag line may be positioned to be separately occludable in relation to one or more solution lines that are connectable to the cassette.

A method and a system (10a) comprising an integrated water purifying apparatus (110) with a pre-filter circuit (402) including a particle filter and an activated carbon filter arranged to produce pre-treated water; a fluid circuit (404) arranged to receive pre-treated water from the pre-filter circuit (402), the fluid circuit (404) includes an RO-pump (450) and a Reverse Osmosis, RO, device, (301) arranged to produce purified water; a heating device (302) arranged to heat purified water from the RO device (301) to a temperature above 65°; the water purifying apparatus (110) is further arranged to heat disinfect the fluid circuit (404) using the heated purified water. The system (1) further comprises a line set (40) connected to the purified water outlet connector (128) at a water line connector (68) of the line set (40), wherein the line set (40) includes at least one sterile sterilizing grade filter (70a, 70b) arranged to filter the purified water into sterile purified water.

A peritoneal dialysis system includes a control unit configured to cause (i) a fluid inlet valve and a fluid outlet valve to occlude a fluid inlet line and a fluid outlet line, respectively, while a linear actuator moves a piston to create a positive pressure within a pump housing, the positive pressure measured by a pressure sensor, and (ii) the fluid inlet valve to occlude the fluid inlet line and the fluid outlet valve to open the fluid outlet line, while the linear actuator moves the piston so as to maintain the positive pressure within the pump housing while fluid is pumped out of the fluid pump chamber via the opened fluid outlet line.

A fluid pumping system may comprise a pump and a fluid line state detector having, a receptacle, at sensor, and an illuminator. The system may further comprise a fluid transfer set including an output line for mating into the receptacle. The system may further comprise a controller in data communication with the fluid line state detector configured to power the illuminator and monitor an output signal of the sensor when the outlet line is in the receptacle to determine a dry tube light intensity value. The controller may be further configured to govern operation of the pump to prime the output line with fluid. The controller may be further configured to power the illuminator, monitor the output signal, and halt operation of the pump when the output signal indicates the light intensity value has dropped below a primed line threshold which is dependent upon the dry tube intensity value.

A fluid handling cassette, such as that useable with an automated peritoneal dialysis (APD) cycler device or other infusion apparatus, may include a generally planar body having at least one pump chamber formed as a depression in a first side of the body and a plurality of flowpaths for a fluid that includes a channel. A patient line port may be arranged for connection to a patient line and be in fluid communication with the at least one pump chamber via at least a first one of said flowpaths, and an optional membrane may be attached to the first side of the body over the at least one pump chamber. In one embodiment, the membrane may have a pump chamber portion with an unstressed shape that generally conforms to the depression of the at least one pump chamber in the body and is arranged to be movable for movement of the fluid in a useable space of the at least one pump chamber. One or more spacers may be provided in the at least one pump chamber to prevent the membrane from contacting an inner wall of the at least one pump chamber. The patient line, a drain line, and/or a heater bag line may be positioned to be separately occludable in relation to one or more solution lines that are connectable to the cassette.

A renal therapy machine includes a blood filter including a plurality of porous fibers; a blood circuit in communication with the blood filter; and a dialysate circuit in communication with the blood filter and operable with at least one pump, wherein the renal therapy machine is configured to perform a priming sequence in which a physiologically compatible solution, other than dialysate, primes the blood circuit and is flowed within the fibers and through pores in the fibers of the blood filter, and the pump of the dialysate circuit vents air from the blood filter into the dialysate circuit.

Techniques for monitoring intraperitoneal volume (IPV) during a dwell period of a peritoneal dialysis patient include monitoring intraperitoneal pressure (IPP) during the dwell period using a pressure sensor, monitoring the density of the dialysate during the dwell period, and determining a change in IPV based at least on a change in IPP and a change in the density of the dialysate during the dwell period.

A peritoneal dialysis system includes a chamber; a hydraulic pump; an inflatable bladder located within the chamber and in hydraulic fluid communication with the hydraulic pump; and a control unit configured to cause known amounts of hydraulic fluid to be metered to and from the inflatable bladder and to determine (i) a first amount of air before a discharge stroke via a first ideal gas law calculation, (ii) a second amount of air after the discharge stroke via a second ideal gas law calculation, and (iii) a discharge volume of fresh or used dialysis fluid for the discharge stroke by subtracting a difference between the first and second amounts of air from a known amount of hydraulic fluid metered to the inflatable bladder for the discharge stroke.

A dialysis machine includes: a hardware unit including at least one pump actuator, at least one valve actuator and a cassette interface, the cassette interface including: (i) a plate that abuts the cassette; (ii) at least one pump aperture defined by the plate; (iii) at least one pump head moveable out of and retractable into the at least one pump aperture to operate a pumping portion of the cassette; (iv) at least one valve aperture defined by the plate; (v) at least one valve apparatus moveable out of and retractable into the at least one valve aperture to operate a valve portion of the cassette; (vi) at least one sensor aperture defined by the plate; and (vii) at least one sensor located in the least one sensor aperture, the at least one sensor operable with a sensor portion of the cassette.

The present invention relates to a method of determining a system compressibility value of a medical membrane pump drive, wherein a first and second pressure level are moved to and a first and second operating parameter value of the membrane pump drive are detected; wherein the system compressibility value is determined on the basis of the detected operating parameter values; and wherein the membrane of the membrane pump drive is supported at a rigid surface during the determination of the system compressibility value.