The present invention provides for systems and methods for inhaled CO therapy to prevent, attenuate, or delay processes that accelerate the loss of organ or tissue function, thereby increasing the lifespan of transplanted organs or tissues, or slowing the decline of native organs or tissues, or delaying the need for replacement of diseased native organs with organ transplants. Such biological processes that are prevented, attenuated, or delayed include chronic persistent inflammation, fibrosis, scarring, as well as immunologic or autoimmune attack.

The present invention provides for systems and methods for inhaled CO therapy to prevent, attenuate, or delay processes that accelerate the loss of organ or tissue function, thereby increasing the lifespan of transplanted organs or tissues, or slowing the decline of native organs or tissues, or delaying the need for replacement of diseased native organs with organ transplants. Such biological processes that are prevented, attenuated, or delayed include chronic persistent inflammation, fibrosis, scarring, as well as immunologic or autoimmune attack.

[Problems] To provide a driving method for a metering pump, a driving apparatus for a metering pump, a vaporizer and an anesthesia apparatus which are capable of suppressing a pulsation in the metering pump, and lowering the costs and reducing the sizes of the vaporizer and the anesthesia apparatus.

[Means for solving the Problems] A metering pump 16 is joined to the stepping motor 15, includes an eccentric mechanism converting a revolving motion of the stepping motor 15 into a reciprocating motion of a plunger 16A, and makes a constant liquid delivery by sucking and discharging an anesthetic agent through variations in the cubic volume of a cylinder 16D caused by the reciprocating motion of the plunger 16A. The control section 12: calculates a suction and discharge cycle T of the metering pump 16 on the basis of a set anesthetic-gas concentration and a fresh-gas flow rate; sets a discharge period T2 of the cycle T to be longer than a suction period T1 of the cycle T; and controls the revolution speed of the stepping motor 15 so that the travelling speed of the plunger 16A is kept constant during the discharge period T2.

A non-invasive ventilation system may include at least one outer tube with a proximal lateral end of the outer tube adapted to extend to a side of a nose. The at least one outer tube may also include a throat section. At least one coupler may be located at a distal section of the outer tube for impinging at least one nostril and positioning the at least one outer tube relative to the at least one nostril. At least one jet nozzle may be positioned within the outer tube at the proximal lateral end and in fluid communication with a pressurized gas supply. At least one opening in the distal section may be adapted to be in fluid communication with the nostril. At least one aperture in the at least one outer tube may be in fluid communication with ambient air. The at least one aperture may be in proximity to the at least one jet nozzle.

The present technology relates to systems and/or methods for enabling a respiratory device to be configured when a clinician or healthcare professional is remote from the respiratory device. One form provides a method of configuring a respiratory device, the respiratory device comprising a processor configured to control operation of the respiratory device in accordance with a plurality of operating parameters. The method comprises determining a combination of settings for the device from an identifier sent to the device, the identifier corresponding to the combination of settings, and configuring the respiratory device accordingly. Another form provides a method of verifying the configuration of the respiratory device by outputting an identifier corresponding to the combination of settings for the device, and determining the settings from the identifier.

Disclosed is a cartridge for storing pressurized gas, including a main body with an internal volume for storing a gaseous mixture NO/N.sub.2, and a distribution valve for controlling the output of the gas. The internal volume of the main body is less than 1000 ml. The concentration of NO in the gaseous mixture NO/N.sub.2 is between 15000 and 25000 ppmv. The gas pressure in the internal volume is below 15 bar, measured at 23° C. Installation for delivering gas to a patient, including such a gas cartridge, a NO supply device fed by the gas cartridge, and a medical ventilator feeding a patient circuit which has an inhalation branch fed by the NO supply device. Use for treating patients suffering from pulmonary hypertension or hypoxia.

Alveolar dead space of a subject is determined by measuring an end tidal partial pressure of carbon dioxide during a sequence of normal breaths of the subject and, during a sequence of deep breaths by the subject, delivering a first volume of a first gas to the subject over a first portion of each inspiration by the subject. The first volume is less than or equal to an expected alveolar volume of the subject when the subject is breathing normally. A second volume of a second gas is delivered to the subject over a second portion of each inspiration. The second gas includes a neutral gas. An end tidal partial pressure of carbon dioxide is measured during the sequence of deep breaths. The alveolar dead space is computed using the end tidal partial pressures of carbon dioxide measured during the sequence of normal breaths and the sequence of deep breaths.

Alveolar dead space of a subject is determined by measuring an end tidal partial pressure of carbon dioxide during a sequence of normal breaths of the subject and, during a sequence of deep breaths by the subject, delivering a first volume of a first gas to the subject over a first portion of each inspiration by the subject. The first volume is less than or equal to an expected alveolar volume of the subject when the subject is breathing normally. A second volume of a second gas is delivered to the subject over a second portion of each inspiration. The second gas includes a neutral gas. An end tidal partial pressure of carbon dioxide is measured during the sequence of deep breaths. The alveolar dead space is computed using the end tidal partial pressures of carbon dioxide measured during the sequence of normal breaths and the sequence of deep breaths.

A respiratory pressure therapy system for providing continuous positive air pressure to a patient via a patient interface configured to engage with at least one airway of the patient. The system includes: a flow generator configured to generate supply of breathable gas for delivery to the patient via the patient interface; at least one sensor; a display; and a computing device. The computing device is configured to: receive sensor data that is based on measured physical property of the supply of breathable gas; control, based on the received sensor data, the flow generator to adjust a property of the supply of breathable gas; receive, an input indicating assistance is needed with using the patient interface; receive one or more images of the patient with the patient interface; analyse the received one or more images; and based on the analysis, display instructions for positioning the patient interface.

A flow of gases in a respiratory therapy system can be conditioned to achieve more consistent output from sensors configured to sense a characteristic of the flow. The flow can be mixed by imparting a tangential, rotary, helical, or swirling motion to the flow of gases. The mixing can occur upstream of the sensors. The flow can be segregated into smaller compartments to reduce turbulence in a region of the sensors.