A syringe assembly includes a plunger assembly, a syringe body, and a needle. The plunger assembly includes a plunger rod, a spring, a plunger base, and a plunger plug. The plunger rod includes a first end member having a first stepped part positioned in an inner wall thereof, a second end member, and a first accommodating room. The plunger base includes a plunger body, a projection, a second stepped part, a plunger member, and a locating member. The plunger body is received in the first accommodating room, and the projection abuts against the first end member. The spring is arranged around the plunger body and positioned between the first stepped part and the second stepped part. The plunger plug is mounted to the second end member, and defines a fixing groove. The syringe body includes a needle cannula, a needle base, a fixing pole, and a fixing valve. The plunger assembly is received in the needle cannula. The needle base is mounted to the needle cannula. The fixing valve is received in the needle base. The fixing pole is received in the fixing valve and protrudes out of the needle base. The needle is received in the fixing pole. The syringe assembly of the present invention is prevented from reuse and accidently damage because the needle can retract into the plunger rod using restoring force of the spring.

Provided is a novel oxygen-absorbing resin composition having excellent oxygen-absorbing performance and suppressing odor generation after absorption of oxygen even if a material responsive to a metal detector is not used. Further provided is an oxygen-absorbing resin composition having excellent oxygen-absorbing performance in a wide range of humidity conditions from low humidity to high humidity. Such an oxygen-absorbing resin composition contains a copolymerized polyolefin compound and a transition metal catalyst, in which the copolymerized polyolefin compound contains at least one constituent unit having a tetralin ring.

An embodiment in accordance with the present invention is directed to a device for use as a cryosyringe and a cryo-storage vial. The device includes a first end and a second end and has an outer wall defining a lumen between the first and second ends. Both the first end and the second end include threads configured for attaching a first cap to the first end and a second cap to the second end. The device can also include a syringe plunger adapter, such that the cryo-storage vial is convertible into a cryosyringe to ensure sterility of the contents. Similarly, a luer-lock adapter can be included to further convert the device into a cryosyringe. The device and its components are formed from a cryo-resistant material. The device can therefore withstand liquid nitrogen temperatures necessary to preserve cell viability and be injected without compromising sterility to dispense the cellular therapy.

A combination plunger, a mixing device and a mixing syringe including the same are provided. The mixing syringe includes concentric outer and inner barrels that form an outer chamber, the inner barrel having an inner chamber. The combination plunger includes a mixing plunger and a delivery plunger and a biasing means. The mixing plunger is slidably located in the outer chamber and translated by coordinated depression of the delivery plunger to transfer a first substance from the outer chamber to mix with a second substance in the inner chamber. After the mixing stage is complete, the delivery plunger is disengaged from the mixing plunger and permitted, such as by rotation, to be further depressed in the axial direction to deliver fluid contents of the mixing syringe to a recipient. The mixing syringe needle is then retracted as result of engagement by the delivery plunger and activation of the biasing means.

A plunger configured as described herein provides geometry optimizations to minimize friction magnitude and variability during use by maintaining low deformation under large extrusion forces. More specifically, plunger embodiments described herein minimize a contact area between the plunger and a syringe or chamber, while also maintaining high contract pressures to maintain container closure integrity. Moreover, the plunger embodiments are configured to have minimal or no increase in the contact area under high loads associated with the delivery of viscous products.

Disclosed is a fluid product injection device comprising: —a syringe comprising a vessel (1) containing fluid product to be injected, a piston (3) being arranged so as to be axially movable in the vessel (1) and a needle (2) provided with an injection tip (20) being attached to the vessel (1), —a piston rod (5) axially movable relative to the vessel (1) and cooperating with the piston (3) during injection in order to move it axially in the vessel (1), —a sleeve (10) arranged around the syringe, being axially movable relative to the vessel (1) between an idle position, in which the sleeve (10) does not cover the injection tip (20) of the needle (2), and a projecting position, in which the sleeve (10) covers the injection tip (20) of the needle (2), the sleeve (10) being in its idle position before actuation of the injection device, the sleeve (10) being moved towards its projecting position after the injection of the fluid product, the sleeve (10) being moved by the piston rod (5).

Flush syringe assemblies are described herein. Such flush syringe assembly may include a barrel including a side wall defining a chamber, an open proximal end, a distal end having a distal wall with an elongate tip extending distally therefrom having a passageway therethrough in fluid communication with said chamber. A collar may be mounted on the distal wall of the barrel and surrounding the elongate tip. A disinfectant-loaded swab may be disposed in the collar. The flush syringe assembly may also include a removable cap.

Disclosed in some forms is a process of limiting the impact of surgery on a nerve, the process comprising applying a therapeutic substance to the nerve during surgery. In some aspects, disclosed is a formulation for reducing nerve trauma comprising an active pharmacological ingredient adapted to intervene in the activation of pathways of cellular degradation within the nerve and a carrier adapted to reduce dissemination of the active pharmacological ingredient beyond the site at which its effect is intended.

Mixing/administration systems and methods for preparing an agent for administration to an individual are disclosed. Caps may be included as part of the system, which may include compositions comprising at least one of a cleansing, antiseptic, antimicrobial, or disinfectant agent. The caps may additionally be included that may be used for hemostasis at an injection site. Packaging and/or the mixing/administration system within it may include a tracking mechanism for data tracking regarding many different aspects of the system, including aspects of manufacture and administration.

A method of inserting a lubricant free stopper into a lubricant free syringe barrel or lubricant free cartridge tube is disclosed. The method includes (1) inserting a stopper with a sealing rib into a placement region, (2) lowering the body of the insertion tube into a syringe barrel or cartridge tube to a position located past the barrel flange or top of the cartridge tube, (3) maneuvering the stopper to a distal opening of the insertion tube using an insertion pin, (4) retracting the insertion tube while the stopper remains in a fixed position within the syringe barrel or cartridge tube, and (5) fully retracting the insertion pin and the insertion tube from the syringe barrel or cartridge tube. The method is lubricant free or substantially lubricant free. The insertion tube may be electropolished and/or extrude honed.