A system for at least partial closed-loop control of a medical condition is disclosed. The system includes at least one medical fluid pump. The medical fluid pump including a sensor for determining the volume of fluid pumped by the pump. Also, at least one continuous analyte monitor, and a controller. The controller is in communication with the medical fluid pump and the at least one continuous analyte monitor. The controller includes a processor. The processor includes instructions for delivery of medical fluid based at least on data received from the at least one continuous analyte monitor.

Pump cassettes, wound-treatment apparatuses and methods. In some embodiments, a pump cassette comprises: a pump body having a pump chamber, an inlet valve in fluid communication with the pump chamber, and an outlet valve in fluid communication with the pump chamber; a diaphragm coupled to the pump body such that the diaphragm is movable to vary a volume in the pump chamber; and an identifier configured to store one or more properties of the pump cassette such that the identifier is readable by an automated reader to determine the one or more properties. In some embodiments, the pump cassette is configured to be removably coupled to a wound-treatment apparatus having an actuator such that the actuator can be activated to move the diaphragm.

A fluid delivery device includes a housing having a bottom surface configured to be coupled to the skin surface. The fluid delivery device includes a cartridge prefilled with a fluid and configured to be inserted into the housing. The cartridge has a septum configured to be generally perpendicular to the bottom surface when the cartridge is inserted in the housing. The fluid delivery device includes a needle assembly that has a needle that includes a fluid coupling end and a delivery end. The fluid coupling end of the needle is fluidly disengaged from the cartridge in an initial position. The delivery end of the needle extends past the plane of the bottom surface and the fluid coupling end of the needle extends through the septum in a deployed position.

A fluid injector system (1000) is configured to perform an injection protocol. The fluid injector system includes a housing (11) and a controller (900) operatively associated with a user input device (40) and a fluid actuator (16). The controller includes at least one processor programmed or configured to determine an orientation of the housing, receive at least one signal from the user input device, determine a direction of fluid actuation based on the orientation of the housing and the at least one signal, and actuate the fluid actuator in the direction of fluid actuation. The direction of fluid actuation corresponds to at least one of actuating the fluid actuator to inject fluid from a fluid reservoir and actuating the fluid actuator to draw fluid into the fluid reservoir.

Delivery systems and their methods of use for delivering one or more therapeutic compounds to a user are described. A delivery system may include an implantable pump and an external actuator. The implantable pump may include an actuatable portion that may be actuated to dispense a volume of fluid. The external actuator may include a pusher configured to deform skin to engage an actuatable portion of the pump. The external actuator may also include a positioning magnet configured to magnetically attract a portion of the implantable pump such that the external actuator and the pump may be aligned prior to applying force to the portion of the skin between the external actuator and the actuatable portion of the pump.

A device for delivering a medication to a patient in a drug infusion system is disclosed. The device is configured as a fully autonomous and integrated wearable apparatus for managing the medication delivery. The device comprises: a reservoir for storing the medication to be delivered to the patient; a continuous glucose monitoring device for monitoring glucose levels in the patient to set flow rates for medication delivery; a needle for delivering the medication from reservoir into the patient; and a pumping unit including one or more MEMS devices configured to function as (a) a pump for pumping the medication from the reservoir through a flow path for medication to the needle at set flow rates and/or (b) a valve for regulating flow of the medication in the flow path from the reservoir through the needle.

A device for delivering a medication to a patient in a drug infusion system is disclosed. The device is configured as a fully autonomous and integrated wearable apparatus for managing the medication delivery. The device comprises: a reservoir for storing the medication to be delivered to the patient; a continuous glucose monitoring device for monitoring glucose levels in the patient to set flow rates for medication delivery; a needle for delivering the medication from reservoir into the patient; and a pumping unit including one or more MEMS devices configured to function as (a) a pump for pumping the medication from the reservoir through a flow path for medication to the needle at set flow rates and/or (b) a valve for regulating flow of the medication in the flow path from the reservoir through the needle.

This application relates to a wearable multi-shot injection patch. In one aspect, the patch includes a base that has a bottom surface and a top surface and is configured so that the bottom surface is disposed against a patient's skin. The patch may also include a first container that is supported by the base and accommodates a first drug, and a second container that is supported by the base and accommodates a second drug. The patch may further include a first pyrotechnic charge disposed between the top surface and the first container inside the base, and a second pyrotechnic charge disposed between the top surface and the second container inside the base. The patch may further include one or more electronic components configured to detonate the first pyrotechnic charge and the second pyrotechnic charge.

A crawling mechanism for a drug delivery device has a central longitudinal axis and is arranged to crawl in an axial direction. The crawling mechanism includes a housing and one or more swing members pivotally coupled to the housing that are arranged to swing relative to the housing between an initial position and a terminal position suitable for urging crawling of the mechanism.

A crawling mechanism for a drug delivery device has a central longitudinal axis and is arranged to crawl in an axial direction. The crawling mechanism includes a housing and one or more swing members pivotally coupled to the housing that are arranged to swing relative to the housing between an initial position and a terminal position suitable for urging crawling of the mechanism.