Disclosed is an iontophoresis administration device. The iontophoresis administration device includes a power supply for generating the electricity needed to penetrate a medicament to be penetrated into an administered area of an organism; an integrated dielectric layer for covering the administered area, and including a gel and the polar, free-state medicament to be penetrated; and a plurality of electrodes for respectively electrically connecting with the power supply and the integrated dielectric layer so that the electricity generated by the power supply flows through the administered areas and at least part of the integrated dielectric layers respectively, and the at least part of the integrated dielectric layers has a predetermined resistance value. The iontophoresis administration device not only can improve the transdermal efficiency, but also are not prone to skin damage.

A device for transport of ions and/or charged molecules between a source and a target electrolyte, comprising: a first electrode provided at or in said source electrolyte, and a second electrode provided at or in said target electrolyte; and wherein said first and second electrodes provides an electrical control of an ion flow, and further comprising means for limiting an electronic current between said source and said target electrodes, such that at least after a voltage is applied a potential difference between said source and target electrodes is maintained, which effects ion transport from said source to said target electrode; wherein the device further comprises an ion- and/or permselective polyelectrolyte for transport ions and/or charged molecules via electrophoresis and functions as an ion-selective membrane; and wherein said polyelectrolyte comprises a cross-linked hyperbranched polymer.

A hydrogel ionic circuit (HIC) electrode configured for electrical stimulation and/or drug therapy (e.g., iontophoresis) is disclosed. The HIC electrode includes a chamber containing a salt solution. The chamber is at least partially bound by a hydrogel membrane that defines a barrier for the salt solution. The HIC electrode further includes an electrode configured to apply an electrical current to the chamber to induce an ion current in the salt solution, wherein the hydrogel membrane is ionically conductive and configured to transmit the ion current.

An adhesive patch for securing a transdermal device to the skin comprises a double-sided adhesive layer. A permeable membrane element is located in an aperture in the adhesive layer. There is a small area of overlap where the adhesive layer adheres to the membrane element to secure it against movement during application and use of the patch.

A surgically implantable reservoir is provided for implantation into a patient for use in an iontophoresis system for local drug delivery through a target site of internal body tissue. The reservoir comprises a housing having an inner surface defining an enclosed chamber and an inlet opening and an outlet opening for flow of fluid including the drug through the chamber. The housing is capable of interacting with a localized electric field to release the drug. A platform holding an electrode extends inwardly into the chamber from the inner surface of the housing such that the platform and an adjacent portion of the inner surface of the housing define a trough surrounding the platform. Fluid flow through the reservoir from the inlet opening to the outlet opening moves gas bubbles formed by electrolysis from the surface of the electrode and carries the bubbles through the outlet opening.

The invention relates to a shape-adaptive medical implant having at least one actuator, which the implant can be changed from a first implant geometry to a second implant geometry, the implant having a different geometric shape in the second implant geometry from that in the first implant geometry, wherein the actuator has a swellable chemical substance which swells when supplied with liquid, and wherein the implant which is designed to supply liquid present outside the implant to the swellable chemical substance. The invention also relates to the use of an electrical signal source.

A reverse electrodialysis device using a precipitation reaction, according to one embodiment of the present invention, comprises a first cell stack alternately forming solid salt chambers and precipitation chambers through cation-exchange membranes and anion-exchange membranes which are alternately provided, and a first water-soluble solid salt and a second water-soluble solid salt which are filled in the solid salt chambers, wherein the first water-soluble solid salt and the second water-soluble solid salt are alternately filled in the solid salt chambers, and can react with each other so as to generate a precipitate in neighboring precipitation chambers when water is supplied.

A device for treating human keratin materials, in particular with the aid of an electric current. The device includes a reservoir containing an in particular cosmetic or dermatological composition to be applied to the keratin materials, a unit for dispensing the composition contained in the reservoir, in particular a pump, and an end fitting for applying the composition contained in the reservoir, comprising at least one applying member and in particular a plurality of applying members. The applying member is supplied with the composition from the reservoir by the dispensing unit, the composition passing through an intermediate chamber for storing the composition located in the end fitting, the intermediate chamber being at least partially defined by an elastically deformable wall.

Electromechanical substance delivery devices are provided which implement low-power electromechanical release mechanisms for controlled delivery of substances such as drugs and medication. For example, an electromechanical device includes a substrate having a cavity formed in a surface of the substrate, a membrane disposed on the surface of the substrate covering an opening of the cavity, and a seal disposed between the membrane and the surface of the substrate. The seal surrounds the opening of the cavity, and the seal and membrane are configured to enclose the cavity and retain a substance within the cavity. An electrode structure is configured to locally heat a portion of the membrane in response to a control voltage applied to the electrode structure, and create a stress that causes a rupture in the locally heated portion of the membrane to release the substance from within the cavity.

A transdermal delivery system (1) configured to deliver an active agent to human or animal tissue, comprising a penetrative electrode (2) of one polarity that provides an electrical contact (3) beneath the stratum corneum (20); a surface electrode (4) of the opposite polarisation to that of the penetrative electrode (2) that provides an electrical contact to the external surface of the skin (21) on the opposite side of the stratum corneum (20) to the electrical contact (3) of the penetrative electrode (2); a dispenser (5) configured to deliver of an active agent to the external surface of the skin (21) adjacent to an electrical contact of the surface electrode (4); a method of delivering the active agent to the tissue of a human or animal body using the transdermal delivery system (1) and an electrode assembly (10) for use in preparing the transdermal delivery system (1).