The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.

The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.

An adapter for use in a filter device is provided, the adapter having a downwardly slanted inner wall including two or more hollow passageways, and a central fluid flow port, wherein the adapter can be welded to a filter device housing head.

The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.

The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.

A filter filters a flow of liquid and has a pressure vessel, a filter assembly deployed within the pressure vessel, and a backwash assembly. The pressure vessel has an inlet, an outlet, and a flow path in fluid communication with the outlet. The filter assembly has at least one filter unit and at least one support configuration that supports the at least one filter element. The at least one filter element has first and second coarse mesh material support layer that have apertures of a first and second size, respectively, and a cloth filter layer that has apertures of a third size smaller than the first and second sizes. The cloth filter layer is interposed between the first and second coarse mesh material support layers. The backwash assembly has a suction nozzle in facing relation to a first or second surface of the filter unit.

A grill device includes a first grill seat and a second grill seat movably connected to the first grill seat such that the second grill seat is movable between a closed position, where the second grill seat overlaps with the first grill seat in an up-and-down direction to define a grill space therebetween for accommodating a food to be grilled, and an opened position. The second grill seat has a fume collecting chamber which is disposed opposite to and in spatial communication with the grill space in the up-and-down direction when the second grill seat is in the closed position so that fumes generated during grilling are dissipated successfully and are spontaneously ventilated and exhausted without the need to provide a power activated impeller, thereby reducing the manufacturing cost and saving energy.

The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.

A filter arrangement includes: a chamber including a chamber inlet for unfiltered liquid, a chamber outlet for filtered liquid and a wall arranged to keep the unfiltered liquid and the filtered liquid separated, a filter element having a longitudinal extension arranged inside of the chamber, wherein the filter element includes a semi-permeable filtration wall including a folded filter arranged in a zig-zag configuration between an inner perforated cylinder and an outer perforated cylinder and an internally located back-washing arrangement. The back-washing arrangement includes: an elongated and hollow body having a longitudinal extension, which is substantially parallel to the longitudinal extension of the filter element, a mechanism configured to drive the body in a rotational and/or an axial movement, a plurality of nozzles arranged in fluid communication with a cavity inside of the body, the plurality of nozzles projecting laterally from the body such that a distal end of each of the plurality of nozzles is arranged in close proximity to the inner perforated cylinder and an outlet arranged in fluid communication with the cavity of the elongated and hollow body and wherein the plurality of nozzles are arranged parallel to each other along a straight line on the body such that they all project in the same direction.

The invention relates to a filter device, in particular for filtering lubrication, consisting of at least one filter insert (19), in which a respective filter material (27) is received and which is provided with fluid passage points (70) that are delimited by wall parts (63) of the filter insert (19) and with a backflush device (37, 49) that has at least one flush nozzle (49), said flush nozzle being movable along the interior of the respective pairable filter insert (19) by means of a hollow drive shaft (37). The invention is characterized in that at least one pair of flush nozzles (49) is provided for each filter insert (19, 21), said flush nozzles having longitudinal slots (73, 74) which are arranged one over the other in the axial direction of the drive shaft (37), wherein the longitudinal slots have an offset relative to one another which runs transversely to the axial direction such that for adjacent flush nozzles (49), at least one part of the longitudinal slot (73) of one flush nozzle (49) overlaps with at least one of the fluid passage points (70) of the pairable filter insert (19, 21) and at least one part of the longitudinal slot (74) of the other flush nozzle (49) at least partly overlaps with the wall parts (63) which delimit the aforementioned fluid passage point of the filter insert (19, 21).