Apparatus and method for semi-permeable membrane cleaning in particular, applying series of pulsed water stroke, made simultaneously with osmosis backward flow causing superposed membrane directional shaking and fouling detachment. Pulsed water stroke provided by water stroke generator as several momentum sharp changes in gauge pressure and induce velocity pulse of residual brine flow. The pulsed water strokes ideally induce resonance in the membrane. Osmosis backward wash may be provided either by injection for predetermined injection time, additional solution selected in such way that net driving pressure becomes opposite to normal osmotic operation thereby providing a backward flow of permeate towards to the side opposite to normal operation mode, so as to lift said foulant, or by throttling permeate exiting from the permeate enclosure, until the net driving pressure value become equal to zero, during application of precise synchronized and opposing brine and permeate pressure strokes thereby providing a plurality of quick RO-FO-RO process changes. These procedures allow a membrane to be kept continuously clean and operate at higher recovery.

A method of cleaning an ultrafiltration membrane module includes installing an ultrafiltration membrane in an ultrafiltration membrane module, supplying deionized water to the ultrafiltration membrane module, and flushing the ultrafiltration membrane module with the deionized water by increasing decreasing a flow rate of the deionized water supplied to the ultrafiltration membrane module.

Enhanced cleaning of a fouled membrane is achieved via controlled deformation in a method wherein a feed composition, comprising a solvent and dissolved components, flows into a retentate side of a membrane module. The solvent passes through the membrane from the retentate side to a permeate or draw side of the membrane module while retaining the dissolved components on the membrane. As a foulant accumulates on either side of the membrane, a driving force is generated across the membrane, wherein the membrane responds cyclically by deforming back and forth toward the permeate or draw side and toward the retentate side. The foulant is dislodged from the membrane via mechanical fatigue at the foulant-membrane interface caused by the deformation of the membrane and contact with a spacer in contact with the membrane.

The present disclosure is directed to various methods and systems for monitoring real time efficiency of filters as well as testing the filters with tests that are similar to real world use of the filters to update technical specifications of the filters. The methods and systems monitoring the real time efficiency of the filters may utilize one or more particle counters to monitor their efficiency in real time. The data collected by the particle counters may be utilized to determine whether respective ones of the filters need to be replaced or regenerated by a backwash regeneration process. The updated technical specifications from the real world testing of the filters may be utilized in determining whether respective ones of the filters need to be replaced or regenerated. These real world testing and real time monitoring reduces the likelihood that workpieces are exposed to contaminant particles reducing scrap costs.

Systems and methods for exchanging buffer solutions are disclosed. In accordance with some embodiments, the methods and systems for buffer exchange may be automated and/or the methods and systems may include mixing during filtering operations.

Systems and methods for exchanging buffer solutions are disclosed. In accordance with some embodiments, the methods and systems for buffer exchange may be automated and/or the methods and systems may include mixing during filtering operations.

Apparatus and method for semi-permeable membrane cleaning in particular, applying series of pulsed water stroke, made simultaneously with osmosis backward flow causing superposed membrane directional shaking and fouling detachment. Pulsed water stroke provided by water stroke generator as several momentum sharp changes in gauge pressure and induce velocity pulse of residual brine flow. The pulsed water strokes ideally induce resonance in the membrane. Osmosis backward wash may be provided either by injection for predetermined injection time, additional solution selected in such way that net driving pressure be-comes opposite to normal osmotic operation thereby providing a backward flow of permeate towards to the side opposite to normal operation mode, so as to lift said foulant, or by throttling permeate exiting from the permeate enclosure, until the net driving pressure value become equal to zero, during application of precise synchronized and opposing brine and permeate pressure strokes thereby providing a plurality of quick RO-FO-RO process changes. These procedures allow a membrane to be kept continuously clean and operate at higher recovery.

The present invention relates to a filtration device being adapted for continuous vibration and pressure driven filtration. Said filtration device comprises a filter module which comprises at least one flat vessel chamber, said vessel chamber further comprises a semipermeable membrane covering a drain area, an inlet for feed fluid, an outlet for permeate and an outlet for retentate; said vessel chamber further comprises one or more flexible volume chambers being filled with gas and in close contact with but separated from the internal vessel chamber of the filter module through a flexible wall; said filtration device comprises a vibration motor being adapted to provide a vibrating motion to the device.

The present invention relates to a filtration device being adapted for continuous vibration and pressure driven filtration. Said filtration device comprises a filter module which comprises at least one tubular semipermeable membrane element, said module further comprises a drain area for permeate, an outlet for permeate, an inlet for feed fluid and an outlet for retentate; said module further comprises one or more flexible volume chambers being filled with gas and in close contact with but separated from the internal module of the filter module through a flexible wall; said filtration device comprises a vibration motor being adapted to provide a vibrating motion to the device.

An isolation device includes an isolation chip, a pressing assembly, two ultrasonic generators, a differential pressure driving system, a frequency conversion module, and a controller. The isolation chip includes a sample reservoir, a first chamber, and a second chamber. The pressing assembly drives the two ultrasonic generators to move towards the isolation chip to make in contact with the first and second chambers. The frequency conversion module controls the differential pressure driving system to generate a negative pressure in the first and second chambers alternately. The controller controls the two ultrasonic generators to generate two ultrasonic waves when negative pressures are cancelled in the first and second chambers. An isolation method is also disclosed.