Disclosed herein are rolled-membrane microfluidic diffusion devices and corresponding methods of manufacture. Also disclosed herein are three-dimensionally printed microfluidic devices and corresponding methods of manufacture. Optionally, the disclosed microfluidic devices can function as artificial lung devices.

A filter medium is provided. The filter medium according to an embodiment of the present invention comprises: a first support body having a plurality of pores; a nanofiber web comprising nanofibers disposed on upper and lower sides of the first support body and forming a three dimensional network structure; and a second support body having a plurality of pores interposed between the first support body and the nanofiber web, wherein the nanofiber web is realized as a filter medium that satisfies: (1) an elongation of 25% or more, (2) an air permeability of 0.1 to 2.00 cfm, and 3) porosity of 60%˜85%. Accordingly, since the filter medium has a fixed level of mechanical properties of the nanofiber web, the shape, structure deformation, and damage of the filter medium are minimized and a flow path is smoothly secured during a water treatment operation so that the filter medium can have a high flow rate. In addition, since the filter medium of the present invention has a prolonged use life due to excellent durability of the filter medium even at high pressure applied during backwashing, and has excellent filtration efficiency and water permeability, the filter medium can be applied in various ways in various water treatment fields.

Membranes suitable for use in membrane distillation are provided. Such membranes may include nano-fibrous layers with adjustable pore sizes. The membranes may include a hydrophobic nanofibrous scaffold and a thin hydrophilic protecting layer that can significantly reduce fouling and scaling problems.

A porous electrospun polymeric nanofiber liquid filtration medium, such as an electrospun mats, used for the removal of viral particles (e.g., parvovirus) and other particles in the 18 nm to 30 nm size range from fluid streams, having a mean flow bubble point measured with perfluorohexane above 100 psi. The electrospun medium includes nanofibers having an average fiber diameter of about 6 nm to about 13 nm, and the nanofiber liquid filtration medium has a mean pore size ranging from about 0.01 μm to about 0.03 μm, a porosity ranging from about 80% to about 95%, a thickness ranging from about 1 μm to about 100 μm, and a liquid permeability greater than about 10 LMH/psi. The high porosity of the electrospun mats enable much higher water fluxes, thus reducing the time required to complete virus filtration steps on a fluid stream.

The present disclosure relates to hollow fiber tangential flow filters, including hollow fiber tangential flow depth filters, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same.

Stabilized surfactant-based membranes and methods of manufacture thereof. Membranes comprising a stabilized surfactant mesostructure on a porous support may be used for various separations, including reverse osmosis and forward osmosis. The membranes are stabilized after evaporation of solvents; in some embodiments no removal of the surfactant is required. The surfactant solution may or may not comprise a hydrophilic compound such as an acid or base. The surface of the porous support is preferably modified prior to formation of the stabilized surfactant mesostructure. The membrane is sufficiently stable to be utilized in commercial separations devices such as spiral wound modules. Also a stabilized surfactant mesostructure coating for a porous material and filters made therefrom. The coating can simultaneously improve both the permeability and the filtration characteristics of the porous material.

Disclosed is a porous support including fine porous structures formed between nanofibers, wherein the fine porous structures have a porosity of 50% to 90%, a pore size of 0.01 μm to 10 μm and an air permeability of 0.01 to 7 sec/100 cc.Math.air, and the porous support has a thickness of 5 μm to 50 μm, a method of manufacturing the same and a reinforced membrane including the same.

A method for producing a hollow fiber pre-product for a dialysis membrane is disclosed. The dialysis membrane includes a distribution of the pore sizes which follows an exponential function such as an e-function. The inverse value of the exponential coefficient (K) is at least 30 nm.sup.2. The dialysis membrane includes at least 50 pores per μm.sup.2 and the share of a free flow area at a surface of the dialysis membrane amounts to at least 2.5%.

A gas separation membrane has a gas separation layer containing a crosslinked cellulose resin. The crosslinked cellulose resin has a particular linking structure in a crosslinked structure. The gas separation layer contains an organic solvent in a particular amount.

Membranes suitable for use in membrane distillation are provided. Such membranes may include nano-fibrous layers with adjustable pore sizes. The membranes may include a hydrophobic nano fibrous scaffold and a thin hydrophilic protecting layer that can significantly reduce fouling and scaling problems.