The invention focuses on a device for sequentially introducing additives in a polymer granulate and the use of the device for mixing the polymer granulate with the additives. The device consisting of a mixer with housing, comprising at least one mixer shaft attached in helix arranged non-continuous conveying pattern shapes, being rotated by a drive for the transport, whereby the mixer in the housing featuring an inlet for the polymer granulate to be mixed and each of the several subsequent inlets for the additive is followed by an outlet for the polymer granulate mixed with the additive, so that two or several mixing zones being formed in the mixer and whereby at least between at two mixing zones on the surface of the mixing shaft one section featuring a continuous screw conveyor instead of the non-continuous conveying pattern shapes, the section not being penetrable for returning solids from the subsequent mixing zone.

The present application relates to novel and improved methods of achieving virus inactivation during a protein purification process.

Disclosed is a liquid-gas mixer including a central passageway provided about an injector axis, and first and second gas passageways. The first gas passageway is radially outward of the central passageway and radially inward of the second gas passageway. A turbulator is provided between the first and second gas passageways, and includes a plurality of first disturbance generators and a plurality of second disturbance generators. The first and second disturbance generators are provided about the turbulator in an alternating arrangement.

A powdery-material feeding device is configured to feed a powdery material to a compression-molding machine configured to obtain a molded product by filling a die bore with the powdery material and to compress the powdery material with punches. The powdery-material feeding device includes a detector configured to detect a biologically-originated foreign matter mixedly contained in the powdery material to be fed to the compression-molding machine, and a controller configured to control to remove the powdery material mixedly containing the biologically-originated foreign matter detected by the detector to avoid feeding of the powdery material mixedly containing the biologically-originated foreign matter to the compression-molding machine, or to control to stop the feeding of the powdery material to the compression-molding machine.

A gas mixing device for linearizing or calibrating a gas analyzer. The gas mixing device includes a first gas inlet line for a first gas, a second gas inlet line for a second gas, a mixing channel having inlet openings which are arranged one behind the other in a flow direction, the inlet openings comprising a first upstream inlet opening and a second downstream inlet opening, and at least two valves which each comprise at least one inlet and one outlet. The at least two valves release or block a fluidic connection between at least one of the first gas inlet line and the second gas inlet line, and the mixing channel via the inlet openings. A flow cross section of the mixing channel is smaller at the first upstream inlet opening than at the second downstream inlet opening.

A powder blender for a system for continuous processing of powder products comprises a horizontal blending tube extending along an axis from a first end to a second end. The horizontal blending tube comprises at least one inlet configured to receive the powder products to be blended, and at least one outlet configured to discharge the powder products after blending. At least two blending devices are positioned in the blending tube and arranged successively along the axis of the blending tube. At least two actuators, wherein each of the at least two actuators is configured to operate one of the at least two blending devices such that the at least two blending devices are actuated differently from each other.

A fluid mixing system includes a support housing having an interior surface bounding a chamber. A flexible bag is disposed within the chamber of the support housing, the flexible bag having an interior surface bounding a compartment. An impeller is disposed within the chamber of the flexible bag. A drive shaft is coupled with the impeller such that rotation of the drive shaft facilitates rotation of the impeller. A drive motor assembly is coupled with the draft shaft and is adapted to rotate the drive shaft. An adjustable arm assembly is coupled with the drive motor assembly and is adapted to move the drive motor assembly which in turn moves the position of the drive shaft and impeller. An electrical controller can control movement of the adjustable arm.

A system and method for pumping fluid using a set of interconnected pump cassettes is disclosed. Each of the pump cassettes can receive a first solution in a first pumping chamber and each of the pump cassettes can receive separate second solutions in respective second pumping chambers, so that the first solution can be mixed with the separate second solutions, each said mixture capable of being placed in separate containers. The system includes a control assembly for operating each pump cassette, each pump cassette having a flexible membrane to pump fluid into and out of the pumping chambers, and each pump cassette configured for mating with a base unit that provides positive or negative pneumatic pressure to the flexible membrane.

A medicament preparation system includes a disposable cartridge with a flow path. Various sensors may be placed on the cartridge to measure qualities of the fluid flowing through the flow path. The sensors are placed in precise locations using various approaches that make manufacturing of the cartridge efficient and repeatable. A drain line that is susceptible to fouling may be preattached and various approaches are used to remove or reduce the fouling. An elastomeric contact can also be present in the medical preparation system and used in a conductivity measurement subsystem.

Continuous method including mixing water and cementitous powder to form slurry; mixing the slurry and reinforcement fibers in a single pass horizontal continuous mixer to form fiber-slurry mixture, the mixer including an elongated mixing chamber having a reinforcement fiber inlet port, and upstream of the fiber inlet port is an inlet port to introduce water and cementitous powder together as one stream or at least two inlet ports to introduce water and dry cementitous powder separately as separate streams into the chamber, a rotating horizontal shaft/s within the chamber, part of the chamber for mixing the fibers and slurry and moving the fiber-slurry mixture to a mixture outlet; discharging the fiber-slurry mixture from the mixer outlet; forming and setting the fiber-slurry mixture on a moving surface; cutting the set mixture into fiber reinforced concrete panels and removing the panels from the moving surface.