The present disclosure provides antibody cytokine engrafted proteins that bind to and stimulate intracellular signaling through a high affinity interleukin receptor. The antibody cytokine engrafted proteins find use in enhancing anti-inflammatory cell responses, and reducing pro-inflammatory effects in the treatment, amelioration and prevention of immune related disorders such as Type 1 Diabetes.

The present disclosure provides antibody cytokine engrafted proteins that bind to and stimulate intracellular signaling through a high affinity interleukin receptor. The antibody cytokine engrafted proteins find use in enhancing anti-inflammatory cell responses, and reducing pro-inflammatory effects in the treatment, amelioration and prevention of immune related disorders such as Type 1 Diabetes.

A canola seed sample crusher features a frame, and a drum rotatably carried on the frame and having an array of seed pockets on an outer periphery thereof. The seed pockets are sized and shaped to receive individual canola seeds respectively therein. A pathway is arranged to receive a length of adhesive tape and guide same over the seed pockets in the outer periphery of the drum during rotation thereof to adhesively collect the sample of canola seeds from the seed pockets onto the adhesive tape. A crushing mechanism is carried on the frame and operatively installed at a position along the pathway to crush the sample of canola seeds collected on the adhesive tape during passage of the tap through the crushing mechanism.

A canola seed sample crusher features a frame, and a drum rotatably carried on the frame and having an array of seed pockets on an outer periphery thereof. The seed pockets are sized and shaped to receive individual canola seeds respectively therein. A pathway is arranged to receive a length of adhesive tape and guide same over the seed pockets in the outer periphery of the drum during rotation thereof to adhesively collect the sample of canola seeds from the seed pockets onto the adhesive tape. A crushing mechanism is carried on the frame and operatively installed at a position along the pathway to crush the sample of canola seeds collected on the adhesive tape during passage of the tap through the crushing mechanism.

A system and method for flaking. The system includes a stationary roller, and moveable roller, and an adjustable fixator applying tension between the stationary and moveable rollers. The fixator includes a pressure transducer and a linear indicator. The transducer and indicator allow the fixator to read pressures and make fine adjustments to the fixator to obtain a desired gap between the two rollers.

A system and method for flaking. The system includes a stationary roller, and moveable roller, and an adjustable fixator applying tension between the stationary and moveable rollers. The fixator includes a pressure transducer and a linear indicator. The transducer and indicator allow the fixator to read pressures and make fine adjustments to the fixator to obtain a desired gap between the two rollers.

The present disclosure provides antibody cytokine engrafted proteins that bind to and stimulate intracellular signaling through a high affinity interleukin receptor. The antibody cytokine engrafted proteins find use in enhancing anti-inflammatory cell responses, and reducing pro-inflammatory effects in the treatment, amelioration and prevention of immune related disorders such as Type 1 Diabetes.

The present disclosure provides antibody cytokine engrafted proteins that bind to and stimulate intracellular signaling through a high affinity interleukin receptor. The antibody cytokine engrafted proteins find use in enhancing anti-inflammatory cell responses, and reducing pro-inflammatory effects in the treatment, amelioration and prevention of immune related disorders such as Type 1 Diabetes.

Roller packages (IO) for grinding devices (70), comprising a first roll (11), which is maintained by at least one first bearing body (13), and a second roll (12), which is maintained by at least one second bearing body (14). The first bearing body (13) and the second bearing body (14) are prestressed against each other and comprise stop elements (17,19) with stop surfaces (18, 20), the contact of which counteracts a contact of the rolls (11, 12). The rotational position of the first stop element (17) determines the minimum width of the grinding gap. Also disclosed are grinding devices (70), methods for operating a roll assembly (10) and methods for determining the radial force acting between the rolls (11, 12) of a roll assembly (10).

Roller packages (IO) for grinding devices (70), comprising a first roll (11), which is maintained by at least one first bearing body (13), and a second roll (12), which is maintained by at least one second bearing body (14). The first bearing body (13) and the second bearing body (14) are prestressed against each other and comprise stop elements (17,19) with stop surfaces (18, 20), the contact of which counteracts a contact of the rolls (11, 12). The rotational position of the first stop element (17) determines the minimum width of the grinding gap. Also disclosed are grinding devices (70), methods for operating a roll assembly (10) and methods for determining the radial force acting between the rolls (11, 12) of a roll assembly (10).