Provided is a system and method for a vaporizer cartridge system wherein the cartridge provides the diffuser. More specifically, an embodiment of the system includes a vaporizing device providing a heating element proximate to a removable cartridge system receiving port, and a dispenser trigger structured and arranged to engage the removable cartridge to dispense a predetermined amount of a liquid concentrate from within the removable cartridge. The system further includes a cartridge with diffuser including: a housing; a reservoir of liquid concentrate; a diffuser element; a metered dispenser structured and arranged to dispense from the reservoir into the diffuser element a predetermined amount of liquid concentrate. An associated method of use is also provided.

The present invention is directed to pharmaceutical products, and to methods for the treatment of depression (e.g., major depressive disorder) and other diseases or disorders for which esketamine has a therapeutic benefit. In some embodiments, the methods are useful for the treatment of treatment-refractory or treatment-resistant depression or suicidal ideation. Methods of intranasal administration and devices for intranasal administration are also disclosed.

A fluid dispenser device including a body; a reservoir containing one or two doses of a fluid, the reservoir including a stopper that closes the reservoir in leaktight manner before actuation; a dispenser head that is provided with a dispenser orifice; and dispenser mechanism for dispensing at least a portion of the fluid through the dispenser orifice during actuation. The device further includes a needle having a tip that is adapted to pierce the stopper during actuation, the reservoir being filled with the fluid and being closed with the stopper under a vacuum, so that the residual volume of air present in the reservoir between the fluid and the stopper is substantially zero.

A fluid dispenser device including a body; a reservoir containing one or two doses of a fluid, the reservoir including a stopper that closes the reservoir in leaktight manner before actuation; a dispenser head that is provided with a dispenser orifice; and dispenser mechanism for dispensing at least a portion of the fluid through the dispenser orifice during actuation. The device further includes a needle having a tip that is adapted to pierce the stopper during actuation, the reservoir being filled with the fluid and being closed with the stopper under a vacuum, so that the residual volume of air present in the reservoir between the fluid and the stopper is substantially zero.

A closure device for sealing a distilled spirits bottle. The closure device has a pair of channels. A first channel extends through the center of the closure device and acts as an air passage. A second channel is arranged along an exterior portion of the rim of the closure devices and extends through the closure device for pouring. A telescoping backbone through which the air passage is extended connects with the bottom of the first channel in the closure device and descends into the bottle. The telescoping backbone can be altered in height to accommodate various sizes of bottle. A tapered bladder extends around the telescoping backbone. The bladder fills an interior portion of the air bladder with fluid first, thereby causing liquid contents of the bottle to raise to a desired level, or fill line.

The present invention is directed to pharmaceutical products, and to methods for the treatment of depression (e.g., major depressive disorder) and other diseases or disorders for which esketamine has a therapeutic benefit. In some embodiments, the methods are useful for the treatment of treatment-refractory or treatment-resistant depression or suicidal ideation. Methods of intranasal administration and devices for intranasal administration are also disclosed.

A bag-in-bottle type of a squeeze dispenser comprising a housing, a cap, a flexible bag for containing fluid, and means to equilibrate atmospheric air pressure with air pressure inside the housing is disclosed. Said means include a closable air channel. The closable air channel, and the cap, may each be in an open or a closed position. When the cap is in an open position, the closable air channel is in a closed position, thus substantially locking the air inside the housing in place and allowing for fluid to be dispensed from the flexible bag upon application of pressing force on the sidewalls of the housing. When the cap is in a closed position, the closable air channel is in an open position, allowing for a flow of atmospheric air into, and out of, the dispenser housing and thereby equilibrating the air pressure inside the housing with air pressure of the atmospheric air.

A fluid dispenser device including a body; a reservoir containing one or two doses of a fluid, the reservoir including a stopper that closes the reservoir in leaktight manner before actuation; a dispenser head that is provided with a dispenser orifice; and dispenser mechanism for dispensing at least a portion of the fluid through the dispenser orifice during actuation. The device further includes a needle having a tip that is adapted to pierce the stopper during actuation, the reservoir being filled with the fluid and being closed with the stopper under a vacuum, so that the residual volume of air present in the reservoir between the fluid and the stopper is substantially zero.

A fluid dispenser device including a body; a reservoir containing one or two doses of a fluid, the reservoir including a stopper that closes the reservoir in leaktight manner before actuation; a dispenser head that is provided with a dispenser orifice; and dispenser mechanism for dispensing at least a portion of the fluid through the dispenser orifice during actuation. The device further includes a needle having a tip that is adapted to pierce the stopper during actuation, the reservoir being filled with the fluid and being closed with the stopper under a vacuum, so that the residual volume of air present in the reservoir between the fluid and the stopper is substantially zero.

Devices, methods, and systems for a Style Sealer Applicator are described herein. One system includes a refillable reservoir integrated into a hair styling tool to dispense hair care products while styling. In some examples, a reservoir is embedded into the handle of a hair styling device and a spring loaded button pressurizes the reservoir to dispense the hair care product through nozzle applicators patterned with other bristles while styling.