Provided herein are devices and systems for depositing a material or manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. Further provided are methods of using the devices and systems, as well as methods of manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. In certain embodiments, the device includes a material supply system configured to melt an pressurized a material, a pressure sensor configured to detect a pressure of the material within the device, and a control switch comprising a sealing needle operable in an open position and closed position. The sealing needle extends through a feed channel containing the material and includes a taper end, wherein the tapered end of the sealing needle engages a tapered inner surface of a nozzle to inhibit flow of the material through the nozzle when the sealing needle is in the closed position.

A method of printing one or more three-dimensional objects comprises: providing a volume of a photopolymerizable liquid in a closed container including an entry port and an exit port, the entry port and the exit port being connected by a channel therebetween, the container including at least one printing zone comprising at least an optically transparent window to facilitate irradiating excitation light at a first wavelength into a printing zone through the at least an optically transparent window, wherein the photopolymerizable liquid displays non-Newtonian rheological behavior such that the object formed in the photopolymerizable liquid within the printing zone remains at a fixed position or is minimally displaced in the unpolymerized photopolymerizable liquid during formation, directing the excitation light through the at least an optically transparent window into the printing zone to selectively photopolymerize the photopolymerizable liquid in the printing zone without support structures to form a printed object, wherein the printed object remains at a fixed position or is minimally displaced in the unpolymerized photopolymerizable liquid during formation, and applying pressure to the contents of the closed container and/or pumping additional photopolymerizable liquid into the closed container through the entry port to at least transport the printed object out of the printing zone toward the exit port, thereby discharging at least a portion of contents of the closed container out of the closed container through the exit port. Systems for printing one or more three-dimensional objects are also disclosed.

A method of printing one or more three-dimensional objects comprises: providing a volume of a photopolymerizable liquid in a closed container including an entry port and an exit port, the entry port and the exit port being connected by a channel therebetween, the container including at least one printing zone comprising at least an optically transparent window to facilitate irradiating excitation light at a first wavelength into a printing zone through the at least an optically transparent window, wherein the photopolymerizable liquid displays non-Newtonian rheological behavior such that the object formed in the photopolymerizable liquid within the printing zone remains at a fixed position or is minimally displaced in the unpolymerized photopolymerizable liquid during formation, directing the excitation light through the at least an optically transparent window into the printing zone to selectively photopolymerize the photopolymerizable liquid in the printing zone without support structures to form a printed object, wherein the printed object remains at a fixed position or is minimally displaced in the unpolymerized photopolymerizable liquid during formation, and applying pressure to the contents of the closed container and/or pumping additional photopolymerizable liquid into the closed container through the entry port to at least transport the printed object out of the printing zone toward the exit port, thereby discharging at least a portion of contents of the closed container out of the closed container through the exit port. Systems for printing one or more three-dimensional objects are also disclosed.

A three-dimensional (“3D”) printing system for printing on a substrate, the printing system including a powder distribution device dispensing powder on the substrate and including a blade-shaped end, the blade-shaped end disposed at a height above the substrate; a powder uniformization device located at a distance from the powder distribution device along a direction substantially parallel to a longitudinal axis of the substrate; one or more sensors disposed upstream from the powder uniformization device and configured to determine one or more parameters of a thickness of the dispensed powder at one or more locations; and a control apparatus configured to determine whether the one or more parameters of the thickness is above a predetermined threshold value, and if the one or more parameters is determined to be above the predetermined threshold value, to adjust the powder distribution device.

An additive manufacturing apparatus includes a stage configured to hold a component. A radiant energy device is operable to generate and project radiant energy in a patterned image. An actuator is configured to change a relative position of the stage relative to the radiant energy device. A resin management system includes a material deposition assembly upstream configured to deposit a resin on a resin support. The material deposition assembly includes a reservoir configured to retain a first volume of the resin and define a thickness of the resin on the resin support as the resin support is translated in an X-axis direction. The material deposition assembly further includes a vessel positioned above the reservoir in a Z-axis direction and configured to store a second volume of the resin. In addition, the material deposition assembly includes a conduit configured to direct the resin from the vessel to the reservoir.

The invention relates to a device (100) for an additive manufacture. The device (100) comprises a laser device (110) for machining material using a laser beam (112), said laser device (110) being designed to deflect the laser beam (112) onto a machining region of a workpiece (10); at least one supply device (130) for a supply material, said supply device being designed to supply the supply material to the machining region; and an interferometer (140) which is designed to measure a distance to the workpiece (10) by means of an optical measuring beam (142).

An additive manufacturing machine is provided. The additive manufacturing machine includes a build unit including a powder dispenser assembly defining a powder reservoir that receives additive powder; a dosing rate measurement device in communication with the powder dispenser assembly, wherein the dosing rate measurement device measures a dosing rate of the additive powder in-situ; and a controllable device operably coupled to the build unit and including one or more processors configured to execute a program to cause the controllable device to adjust the dosing rate of the additive powder based on the dosing rate measured by the dosing rate measurement device.

An additive manufacturing machine is provided. The additive manufacturing machine includes a build unit including a powder dispenser assembly defining a powder reservoir that receives additive powder; a dosing rate measurement device in communication with the powder dispenser assembly, wherein the dosing rate measurement device measures a dosing rate of the additive powder in-situ; and a controllable device operably coupled to the build unit and including one or more processors configured to execute a program to cause the controllable device to adjust the dosing rate of the additive powder based on the dosing rate measured by the dosing rate measurement device.

An additive manufacturing machine having a build vessel defining a work surface is provided. The additive manufacturing machine includes a build unit including a powder dispenser assembly defining a powder reservoir that receives additive powder; a positioning system adapted to provide independent movement of at least one of the build unit and the work surface with respect to one another in at least two dimensions; and a dosing rate measurement device in communication with the powder dispenser assembly, wherein the dosing rate measurement device measures a dosing rate of the additive powder in-situ.

An additive manufacturing machine having a build vessel defining a work surface is provided. The additive manufacturing machine includes a build unit including a powder dispenser assembly defining a powder reservoir that receives additive powder; a positioning system adapted to provide independent movement of at least one of the build unit and the work surface with respect to one another in at least two dimensions; and a dosing rate measurement device in communication with the powder dispenser assembly, wherein the dosing rate measurement device measures a dosing rate of the additive powder in-situ.