Non-invasive Ocular Drug Delivery Insert Technology. The invention concerns an ocular insert which is a new biocompatible polymer-based controlled drug delivery system (CDDS) applicable to a variety of drugs and other compounds for the treatment of different ocular pathologies. This ocular insert allows releasing of at least one drug under suitable concentration levels during suitable periods of time. The device may be inserted in the lower or upper fornix conjunctiva, in a non-invasive way, meaning that the patient will be able to place the device himself, without intervention of medical specialized staff. The insert of the invention will release the drug in such a controlled rate that will allow the drug release up to 300 days by either a “Fickian” or a linear profile according to the intend purpose or pathology. The insert can be prepared with different shapes (spherical or spherical dome) and/or architectures (monolithic/layered either with or without a drug core) allowing the incorporation of at least one drug which can be released at different rates. The size, shape and design of the insert is adjusted in order to tune the drug(s) delivery profile(s) and to inhibit the risk of displacement or expulsion.

The present invention is directed to bioresorbable polymers to be used as bone and tissue adhesives. The present invention is also directed to the synthesis of bioresorbable polymeric molecules bearing adhesive moieties and the use of such compounds in methods to glue and stabilize fractured bones and damaged tissues. The present invention is also directed to the use of such compounds as adhesive sealants for applications in wound care. The present invention is also directed to the use of such compounds as biodegradable ink for applications in tissue engineering and 3D printing. The present invention also relates to the use of such compounds as drug delivery platforms.

The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.

A laser-weldable composition and method using the same, said composition comprising at least one amorphous polyamide made from the polycondensation of at least an acyclic aliphatic diamine comprising at least 10 carbon atoms and/or at least an acyclic aliphatic diacid comprising at least 10 carbon atoms, and at least a phthalic acid selected from the group consisting of terephthalic acid and isophthalic acid, at least one flat glass fiber; and at least one organic dye which absorbs radiation at a wavelength from 800 to 1400 nm.

A laser-weldable composition and method using the same, said composition comprising at least one amorphous polyamide made from the polycondensation of at least an acyclic aliphatic diamine comprising at least 10 carbon atoms and/or at least an acyclic aliphatic diacid comprising at least 10 carbon atoms, and at least a phthalic acid selected from the group consisting of terephthalic acid and isophthalic acid, at least one flat glass fiber; and at least one organic dye which absorbs radiation at a wavelength from 800 to 1400 nm.

The present invention relates to a polyamide resin composition that is excellent in mechanical characteristics, bonding properties and calcium chloride resistance and is suitably bonded to an acid-modified polyolefin, wherein the polyamide resin composition includes 70 to 99 mass % of an aliphatic polyamide resin (A) having an amino group concentration of 46 to 110 μmol/g, 0 to 18 mass % of an aromatic polyamide resin (B), 0.01 to 0.50 mass % of a polyalkylene glycol alkyl ether (C), 0.01 to 0.50 mass % of a polyolefin wax (D) and 0 to 22.98 mass % of a component (E) other than (A) to (D), and the total of (A) to (E) is 100 mass %, and wherein the acid-modified polyolefin having an amount of acid modification of 8 to 100 μmol/g.

The present disclosure is drawn to food contact compliant three-dimensional printing kits and systems. In one example, a multi-fluid kit of food contact compliant agents for three-dimensional printing can include a food contact compliant fusing agent and a food contact compliant detailing agent. The fusing agent can include from about 70 wt % to about 96 wt % water, a food contact compliant carbon black dispersion in an amount of from about 3 wt % to about 10 wt % by solids weight of the carbon black dispersion, and food grade propylene glycol in an amount from about 1 wt % to about 15 wt %. The detailing agent can include from about 70 wt % to about 90 wt % water, food grade propylene glycol in an amount from about 10 wt % to about 25 wt %, and a food contact compliant chelating compound in an amount of from about 0.01 wt % to about 1 wt %.

The present disclosure is drawn to food contact compliant three-dimensional printing kits, materials, compositions, systems, and methods. In some examples, described herein is an example of a multi-fluid kit for three-dimensional printing comprising: a food contact compliant fusing agent comprising: at least about 70 wt % water based on the total weight of the food contact compliant fusing agent, food contact compliant carbon black dispersion in an amount of from about 3 wt % to about 10 wt % based on the total weight of the food contact compliant fusing agent, and at least one food contact compliant water soluble first co-solvent present in the food contact compliant fusing agent in an amount of from about 1 wt % to about 25 wt % based on the total weight of the food contact compliant fusing agent.

A method for preparing a sacrificial support material for use in printing a three-dimensional (3D) article includes providing a water-soluble thermoplastic polymer composite including a water-soluble thermoplastic polyethylene oxide graft polymer having a polyethylene oxide polymer backbone, and from about 0.05% to about 10% by weight of the polyethylene oxide polymer backbone of at least one polar vinyl monomer grafted to the polyethylene oxide polymer backbone. One or more nanoscopic particulate processing aids may be uniformly dispersed in the graft polymer in an amount of from about 0.05% to about 10% by weight of the water-soluble thermoplastic polymer composite. The water-soluble thermoplastic polymer composite may have a viscosity in the range of about 100 to about 10,000 Pa-sec. The method may also include forming the water-soluble thermoplastic polymer composite into the 3D printable sacrificial support material.

The disclosure describes an injection molding process for coating a tablet core to produce a coated pharmaceutical tablet, wherein the injection-molded coating is substantially continuous (e.g., completely covers the tablet core with no openings), and describes the resulting coated pharmaceutical tablet. The disclosure describes compositions for coatings and tablet cores and equipment suitable for performing the process.