A foam molding apparatus and a foam molding method thereby are proposed. The foam molding apparatus includes a foaming agent supply unit configured to supply a foaming agent, a molten resin supply unit configured to supply molten resin, a fixed mixing unit configured to produce a foaming resin-critical solution by mixing a foaming agent supplied from the foaming agent supply unit and molten resin supplied from the molten resin supply unit through a rod-shaped body, and a molding unit configured to mold a foam molding product using the foaming resin-critical solution supplied from the fixed mixing unit. Accordingly, it is possible to produce a foaming resin-critical solution by uniformly mixing a large amount of high-viscosity gel-state molten resin and a high-pressure compressed and low-viscosity foaming agent, using high-strength multiple channels.

The present invention relates to a freeze-drying mold and a method for manufacturing water-soluble polymer balls using the same, more specifically to a freeze-drying mold that is provided with a first mold having a plurality of first accommodation grooves formed on underside thereof and a plurality of discharge portions formed on top thereof to communicate with the plurality of first accommodation grooves and a second mold having a plurality of second accommodation grooves formed on top thereof to be facingly coupled to the plurality of first accommodation grooves of the first mold to thus provide a plurality of accommodation portions, and a method for manufacturing water-soluble polymer balls using the same.

According to the present invention, the freeze-drying mold is capable of controlling the shrinkage rate of a solution in a freeze-drying process to make freeze-dried spherical materials, easily separating the made freeze-dried materials therefrom, and optimizing a drying efficiency thereof, and the method for manufacturing water-soluble polymer balls using the same is carried out so that the water-soluble polymer balls are constant in pore sizes and distributions, have high strength, and do not have any films on the surfaces thereof.

Provided are a transdermal absorption sheet capable of achieving control of the dissolution rate and suppression of diffusion of a drug, and a method of producing the same. A transdermal absorption sheet includes a sheet portion, and a plurality of needle-like protruding portions formed by a plurality of frustum portions arranged on the sheet portion and needle portions arranged on the frustum portions, in which at least one of the needle-like protruding portions has a cavity portion extending from the sheet portion to the frustum portion.

The method, characterized in that, the powdered chitosan is dissolved in water to obtain a 5% solution, into which a 70-90% acetic acid is added and after the formation of the blank intramedullary nail and carrying a coagulating bath and neutralization bath it is subjected to a crosslinking bath in a solution formed from 0.5 to 2% of sodium tri-polyphosphate and 0.5% to 3% Na3PO4 for 24 to 48 hours in temperature of 50° C. to 140° C. and then it is subjected to the drying process, for a period of 6 to 10 days, and finally the surface of the blank is treated to form the intramedullary nail. The surface treatment is carried out until the surface of the intramedullary nail contains at least 20%-40% of the pore of the depth of 0.1 mm to 1 mm.

A method of preparing a polymer film having an oriented dispersed material includes casting a multi-layer polymer solution having a first polymer solution layer and a second polymer solution layer where the second polymer solution layer is at least partially immiscible with the first polymer solution layer. The method further includes passing the multi-layer polymer solution through an electric field application zone, to thereby induce orientation of the dispersed material. A multi-layer polymer film can then be formed by drying the solvent from the multi-layer polymer solution. An apparatus for preparing polymer films includes a top electrode made from a flexible metal mesh coated with a non-stick, non-conductive coating.

Provided is a biodegradable ocular implant for sustained drug delivery, including a first layer comprising a first biodegradable polymer, wherein the first layer contains a drug dispersed or dissolved therein. A multi-layered biodegradable ocular implant is also disclosed.

In polymer electrolyte membrane (PEM) fuel cells and electrolyzes, attaining and maintaining high membrane conductivity and durability is crucial for performance and efficiency. The use of low equivalent weight (EW) perfluorinated ionomers is one of the few options available to improve membrane conductivity. However, excessive dimensional changes of low EW ionomers upon application of wet/dry or freeze/thaw cycles yield catastrophic losses in membrane integrity. Incorporation of ionomers within porous, dimensionally-stable perforated polymer electrolyte membrane substrates provides improved PEM performance and longevity. The present invention provides novel methods using micromolds to fabricate the perforated polymer electrolyte membrane substrates. These novel methods using micromolds create uniform and well-defined pore structures. In addition, these novel methods using micromolds described herein may be used in batch or continuous processing.

Provided is a method of manufacturing a microneedle array in which an active ingredient is concentrated at a tip while an active ingredient content is guaranteed. In order to achieve the object, a method of manufacturing a microneedle array in which needle-like recessed portions of a mold are filled with a liquid to form one dose of a patch includes determining a filling amount of the liquid from a difference in mass of the mold before and after filling of the liquid, determining a filling state of the liquid in the mold filled with the liquid, sucking the mold in which the filling amount and the filling state of the liquid are determined to be normal from a rear face, and evaporating and drying a solvent of the liquid of the sucked mold.

Bone tissue biomimetic materials, biomimetic constructs that can be formed with the materials, and methods for forming the materials and constructs are described. The bone tissue biomimetic materials include electrospun nanofibers formed of polymers that are conjugated with peptides that include acidic amino acid residues. The materials can incorporate high levels of mineralization so as to provide mechanical strength and promote osteogenesis and/or osteoconductivity on/in the bone tissue biomimetic materials. The materials and constructs can be utilized in forming tissue engineered structures for in vitro and in vivo use. Macroscopic bone tissue biomimetic scaffolds formed from the materials can be seeded with osteogenic cells and utilized to develop bone graft materials that can exhibit strength and osteoconductivity similar to the native bone and that exhibit uniform distribution of nutrients in the scaffolds.

The technology relates to a method of producing a moulded polyurethane hydrogel, for example a condom. The method involves forming a solution of at least one polyurethane having a molecular weight of between about 40000 to about 500000 in a water:organic polar solvent comprising less than about 40% (v/v) water; applying a layer of the solution to a mould; drying the layer of the first solution to form a polyurethane film on the mould; and contacting the polyurethane film with a swelling agent under conditions such that the film forms a polyurethane hydrogel with a swelling agent content of between about 1% to about 95%.