The present invention relates to Tetracyclic Heterocycle Compounds of Formula ##STR00001##
and pharmaceutically acceptable salts or prodrug thereof, wherein A, X, R.sup.1, R.sup.2, R.sup.3 and Ware as defined herein. The present invention also relates to compositions comprising at least one Tetracyclic Heterocycle Compound, and methods of using the Tetracyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.

A propeller system combines innovative strategies to create a new methodology to reduce propeller or rotor noise. The propeller is specifically aimed for ultra-quiet electrically powered aircraft for use in high proximity aviation, but its low-noise advantages will extend to other purposes. The propeller blade includes geometries, along with size and operational limitations that minimize rotational and vortex noise, vibration and span-wise air flow on the blade. To further reduce noise, the propeller provides greater relative thrust on the inboard portions of the blade than do conventional propellers and provides less than conventional relative thrust including negative thrust at the outermost portions of the blade. The propeller blade includes stepped changes in local blade stiffness at calculated intervals that can reduce resonant blade vibrations and their resultant noise. This ultra-quiet propeller design can also be used for quieting hovercraft, drones, surveillance aircraft, indoor fans, wind tunnels and other applications.

A propeller system combines innovative strategies to create a new methodology to reduce propeller or rotor noise. The propeller is specifically aimed for ultra-quiet electrically powered aircraft for use in high proximity aviation, but its low-noise advantages will extend to other purposes. The propeller blade includes geometries, along with size and operational limitations that minimize rotational and vortex noise, vibration and span-wise air flow on the blade. To further reduce noise, the propeller provides greater relative thrust on the inboard portions of the blade than do conventional propellers and provides less than conventional relative thrust including negative thrust at the outermost portions of the blade. The propeller blade includes stepped changes in local blade stiffness at calculated intervals that can reduce resonant blade vibrations and their resultant noise. This ultra-quiet propeller design can also be used for quieting hovercraft, drones, surveillance aircraft, indoor fans, wind tunnels and other applications.

The aircraft can include: an airframe, a tilt mechanism, a payload housing, and can optionally include an impact attenuator, a set of ground support members (e.g., struts), a set of power sources, and a set of control elements. The airframe can include: a set of rotors and a set of support members. By utilizing a larger rotor blade area (and/or larger rotor disc area) and adjusting the blade pitch and RPM, the rotors can augment the lift generated by the aerodynamic profile of the aircraft in the forward flight mode in addition to providing forward thrust. Variants generating lift with the rotors can reduce or eliminate additional control surfaces (e.g., wing flaps, ailerons, ruddervators, elevators, rudder, etc.) on the aircraft since the thrust and motor torque is controllable (thereby indirectly controlling lift) at each rotor, thereby enabling pitch, yaw, and/or roll control during forward flight.

The aircraft can include: an airframe, a tilt mechanism, a payload housing, and can optionally include an impact attenuator, a set of ground support members (e.g., struts), a set of power sources, and a set of control elements. The airframe can include: a set of rotors and a set of support members. By utilizing a larger rotor blade area (and/or larger rotor disc area) and adjusting the blade pitch and RPM, the rotors can augment the lift generated by the aerodynamic profile of the aircraft in the forward flight mode in addition to providing forward thrust. Variants generating lift with the rotors can reduce or eliminate additional control surfaces (e.g., wing flaps, ailerons, ruddervators, elevators, rudder, etc.) on the aircraft since the thrust and motor torque is controllable (thereby indirectly controlling lift) at each rotor, thereby enabling pitch, yaw, and/or roll control during forward flight.

Aspects of the technology relate to a propeller blade assembly that is used in lateral propulsion systems for lighter-than-air high altitude platforms designed to operate, e.g., in the stratosphere. During operation, the propeller of the assembly is pointed along a specified heading and rotates at a selected velocity (e.g., hundreds or thousands of revolutions per minute). Power is supplied to the propeller as needed during lateral propulsion to move the platform along a particular trajectory or to remain on station over a given geographic location. In certain circumstances, the propeller may become damaged. This can include one or more blades breaking or shattering, which can result in failure of the propeller and potentially the entire LTA platform. The technology provides blades that are sufficiently flexible to avoid breakage or shattering due to debris impact or envelope entanglement, or otherwise shed a load. This can avoid catastrophic failure during stratospheric operation.

An aerial vehicle includes an airframe; vertical propulsion units, and a controller. The vertical propulsion units are mounted to the airframe and include propellers oriented to provide vertical propulsion to the aerial vehicle. The vertical propulsion units are physically organized in quadrants on the airframe with each of the quadrants including two or more of the vertical propulsion units. The controller is coupled to the vertical propulsion units to control operation of the vertical propulsion units. At least two of the vertical propulsion units in each of the quadrants are adapted to counter-rotate from each other during flight of the aerial vehicle.

A propeller system combines innovative strategies to create a new methodology to reduce propeller or rotor noise. The propeller is specifically aimed for ultra-quiet electrically powered aircraft for use in high proximity aviation, but its low-noise advantages will extend to other purposes. The propeller blade includes geometries, along with size and operational limitations that minimize rotational and vortex noise, vibration and span-wise air flow on the blade. To further reduce noise, the propeller provides greater relative thrust on the inboard portions of the blade than do conventional propellers and provides less than conventional relative thrust including negative thrust at the outermost portions of the blade. The propeller blade includes stepped changes in local blade stiffness at calculated intervals that can reduce resonant blade vibrations and their resultant noise. This ultra-quiet propeller design can also be used for quieting hovercraft, drones, surveillance aircraft, indoor fans, wind tunnels and other applications.

The aircraft can include: an airframe, a tilt mechanism, a payload housing, and can optionally include an impact attenuator, a set of ground support members (e.g., struts), a set of power sources, and a set of control elements. The airframe can include: a set of rotors and a set of support members.

An air vehicle configured to augment effective drag to change the rate of descent of the air vehicle in flight via propeller shaft rotation direction reversal, i.e., thrust reversal.