An evacuated bottle system including a bottle defining a hollow interior, the bottle having a neck with a rim defining an opening; a cap assembly supported on the bottle, the cap assembly including a funnel having a first portion and a second portion, the first portion being insertable within the interior of the bottle and the second portion engaging a portion of the bottle to support the funnel above the rim, the funnel defining a bore that fluidly communicates with the hollow interior of the bottle; a self-sealing membrane that covers the bore formed by the funnel to selectively seal the hollow interior of the bottle; a cap attachable to the bottle, the cap including a cover portion that extends at least partially over the self-sealing membrane to restrain movement thereof, the cover portion being axially spaced from the self-sealing membrane to define a gap that permits axial movement of the self-sealing membrane to selectively open the bottle to fluid communication outside of the bottle.

A machine (10) to automatically transport, from and to one or more working stations (12), one or more components (11) to make a package, comprises a reference surface (13), with which electric energizing members (14) are associated to selectively generate one or more magnetic fields, and at least a pair of support members (15) each provided with magnetic means (16) configured to interact with the magnetic fields. The machine (10) comprises control means (17) configured to energize selectively and in a coordinated manner the electric energizing members (14) to cause the selective movement of each support member (15) from one point to another of the reference surface (13). Each support member (15) is also provided with respective gripping means (18) comprising at least one support arm (19), wherein the support arm (19) of the first support member (15) is configured to cooperate with the support arm (19) of the second support member (15) to selectively temporarily grip and support at least one or more components (11).

The present invention relates to a device for vacuum and vent tube stoppering a medical container. The device includes a main body defining an internal volume that has a first variable pressure chamber configured to be connected to a vacuum pump, the main body being configured to receive the proximal end of a medical container so that said medical container is in communication with the first variable pressure chamber. A vent device including a vent tube is moveable inside the internal volume of the main body along a longitudinal axis between a proximal rest position and a distal operative position. A piston rod is moveable inside the internal volume of the vent tube along the longitudinal axis between a proximal rest position and a distal operative position. A container holder system is provided in the main body, in communication with the first variable pressure chamber.

An evacuated bottle system including a bottle defining a hollow interior, the bottle having a neck with a rim defining an opening; a cap assembly supported on the bottle, the cap assembly including a funnel having a first portion and a second portion, the first portion being insertable within the interior of the bottle and the second portion engaging a portion of the bottle to support the funnel above the rim, the funnel defining a bore that fluidly communicates with the hollow interior of the bottle; a self-sealing membrane that covers the bore formed by the funnel to selectively seal the hollow interior of the bottle; a cap attachable to the bottle, the cap including a cover portion that extends at least partially over the self-sealing membrane to restrain movement thereof, the cover portion being axially spaced from the self-sealing membrane to define a gap that permits axial movement of the self-sealing membrane to selectively open the bottle to fluid communication outside of the bottle.

The present invention relates to a vial that is at least partially filled with an aqueous formulation of a neurotoxin, preferably botulinum toxin, to the manufacture of the vial and to the use thereof. The aqueous formulation of a neurotoxin is stable in the vial for a prolonged period of time.

A cap assembly including a self-sealing membrane that overlaps an opening to an interior of a container. The cap assembly further includes a cap having a cover portion that includes an annular wall that defines a central opening, and at least one evacuating opening located radially outward of the central opening. The cover portion defines a gap above the self-sealing membrane. The gap is configured to allow the self-sealing membrane to be at least partially displaced from the opening to allow fluid communication between the interior of the container and an outside atmosphere when a suction is applied to the cap.

The invention relates to a device for vacuum stoppering a medical container. The device includes a main body defining an internal volume that has a variable pressure chamber configured to be connected to a vacuum pump. A stopper holder system is arranged in communication with the variable pressure chamber and is configured to receive and hold a stopper aligned with the direction of travel of a piston rod. A piston rod is moveable inside the internal volume of the main body along a longitudinal axis between a proximal rest position and a distal operative position wherein the piston rod pushes the stopper into the medical container. A container holder system provided in the main body, is arranged distally relative to the stopper holder system and in communication with the variable pressure chamber.

An evacuated bottle system including a bottle defining a hollow interior, the bottle having a neck with a rim defining an opening; a cap assembly supported on the bottle, the cap assembly including a funnel having a first portion and a second portion, the first portion being insertable within the interior of the bottle and the second portion engaging a portion of the bottle to support the funnel above the rim, the funnel defining a bore that fluidly communicates with the hollow interior of the bottle; a self-sealing membrane that covers the bore formed by the funnel to selectively seal the hollow interior of the bottle; a cap attachable to the bottle, the cap including a cover portion that extends at least partially over the self-sealing membrane to restrain movement thereof, the cover portion being axially spaced from the self-sealing membrane to define a gap that permits axial movement of the self-sealing membrane to selectively open the bottle to fluid communication outside of the bottle.

A cap assembly including a self-sealing membrane that overlaps an opening to an interior of a container. The cap assembly further includes a cap having a cover portion that includes an annular wall that defines a central opening, and at least one evacuating opening located radially outward of the central opening. The cover portion defines a gap above the self-sealing membrane. The gap is configured to allow the self-sealing membrane to be at least partially displaced from the opening to allow fluid communication between the interior of the container and an outside atmosphere when a suction is applied to the cap.

An evacuated bottle system including a bottle defining a hollow interior, the bottle having a neck defining an opening that provides fluid communication with the interior; a cap assembly including a funnel having a first portion and a second portion, where the second portion extends radially outward from the first portion to form a floor on an interior thereof and a shoulder on an exterior thereof, the first portion defining a first bore and the second portion defining a second bore fluidly connected to the first bore; a self serum stopper having a self sealing membrane that extends radially outward to overlie at least a portion of the floor of the funnel; and a cap having a cap wall sized to fit over the funnel and a cover portion extending radially inward from the cap wall.