A method of manufacturing a dry solid comprising a hypochlorite and a chlorite may include preparing a solution comprising a hypochlorite ion, a chlorate ion, and a chloride ion; a first reaction step for adding sulfuric acid to the solution to generate chlorine gas; reacting the generated chlorine gas with sodium hydroxide or calcium hydroxide and recovering a reaction product as a hypochlorite ion in recovery liquid A; a second reaction step for adding sulfuric acid to a reaction mother liquor after the first reaction step at a concentration that is higher than that in the first reaction step to generate chlorine dioxide gas; reacting the generated chlorine dioxide gas with sodium hydroxide and hydrogen peroxide and recovering a reaction product as a chlorite ion in recovery liquid B; mixing recovery liquid A with recovery liquid B; and drying and solidifying the resulting mixture.

Provided herein are methods and composition for the treatment for macrophage-related disorders, for example through the use of biomarkers for selection of responders and treatment monitoring.