A zirconia material manufacturing method includes: dispersing hydroxyapatite powder in water to prepare a slurry having a hydroxyapatite powder concentration of 1%; and dipping zirconia in the slurry to form, on the zirconia, a coating layer containing hydroxyapatite.

The invention relates to a process for the preparation of a citrate-coated amorphous calcium phosphate nanoparticle which comprises the following steps: 1) providing a first solution of a salt of calcium and a citrate salt wherein the molar ratio of citrate ion to calcium ion is in the range from 1 to 2 thus obtaining a clear first solution; 2) providing a second solution of a salt capable to give phosphate anion and a carbonate salt; 3) mixing together the first and the second solution at a pH in the range from 8 to 11; 4) precipitating the nanoparticle; and 5) drying the nanoparticle obtained from step 4). Preferably and advantageously the invention provides for the addition of a fluoride compound in step 2) for obtaining a fluorine-doped citrate-coated calcium phosphate nanoparticle or a nanoparticle agglomerate. The nanoparticle/nanoparticle agglomerate of the invention has a peculiar superficial area and a diameter that allow to use it as a biomaterial for dentistry application.

A process for removing metals and other impurities in a phosphate-containing material, comprising causing the material to react with a metal removing agent which comprises an organophosphorus compound. The process may be integrated to existing transportation and/or storage facilities for phosphate-containing materials.

This invention relates to production method comprising processes of slip casting and freeze drying, which is a hybrid system, for developing hydroxyapatite-containing bio-ceramic developed by combined utilization of medical and engineering sciences in order to use on bone diseases, wherein it discloses a new hybrid system comprising process steps of preparing a first suspension containing powder ceramic, solvent and dispersant mixture by slip casting method, molding the first suspension mixture and allowing it to dry from outside to inside, pouring excessive (residual) slip (first suspension) out of the mold when it reaches to desired thickness, removing the material shaped to form compact part (6) of the bone cortical layer from the mold, preparation of the second suspension mixture comprising powder ceramic, solvent, dispersant and binder for the formation of the trabecular part (5) by freeze drying, cooling the second suspension until the liquid (1) is frozen so as to form trabecular part (5), obtaining the solid (2) by removing the free water in the substance to be dried in the first drying phase, removing the relative water to obtain vapor (3) in the second drying phase.

The present invention relates to a method of quickly preparing a large amount of octacalcium phosphate and octacalcium phosphate prepared thereby. A method of preparing octacalcium phosphate according to an embodiment of the present invention includes preparing a calcium phosphate solution, controlling an initial pH by controlling a pH of the calcium phosphate solution to a range from 5 to 6 using an acidic solution at a time point at which the pH of the calcium phosphate solution increases, heating the calcium phosphate solution to a temperature ranging from 60° C. to 90° C., and controlling a terminal pH by controlling the pH of the calcium phosphate solution to a range from 5 to 6 using a basic solution at a time point at which the pH of the heated calcium phosphate solution decreases.

The invention relates to hardenable ceramic bone substitute compositions having improved setting, powders for such compositions and methods for their manufacture and use in medical treatment. More specifically the invention relates to hardenable bone substitute powder and hardenable bone substitute paste with improved setting properties, comprising calcium sulfate and heat-treated hydroxyapatite (passivated HA), which bone substitute is suitable for treatment of disorders of supportive tissue such as bone loss, bone fracture, bone trauma and osteomyelitis.

The present invention relates to a method for constructing a whitlockite coating on a surface of a calcium phosphate-based bioceramic substrate and a resulting coating, wherein the preparation method includes the following steps of: preparing pure calcium phosphate-based bioceramic powder firstly, then pre-firing, shaping and calcining the pure calcium phosphate-based bioceramic powder to obtain a calcium phosphate-based bioceramic substrate, placing the substrate in a solution containing Mg.sup.2+, then transferring the substrate to a high-temperature high-pressure reaction kettle for a hydrothermal reaction, and then cleaning and drying the sample to obtain a whitlockite coating.

The present invention is situated in the field of mineral micro-particles selected from the list consisting of aluminum hydroxide, aluminum phosphate, amorphous aluminium hydroxyphosphate and calcium phosphate micro-particles. More particularly, the invention provides organically-derivatized mineral micro-particles, uses thereof, and methods of preparing the same.

In order to provide a film-forming powder using hydroxyapatite which is a main component of teeth, or hydroxyapatite in which a color tone adjuster is blended, the powder being used in a jet-device for forming a film on a surface of a tooth by spraying the powder on the tooth, and being suitable for forming a film having a high hardness and extremely low solubility in acid in a short period of time, and suitable for forming a film of a powder conforming to the color tone of a tooth in a short period of time; a hydroxyapatite powder calcined in an inert gas atmosphere at 600 to 1350° C., a powder obtained by applying to the hydroxyapatite powder calcined at 600 to 1350° C. plasma irradiation, or plasma irradiation and mechanical energy, and additionally a film-forming powders obtained by blending color tone adjusters into these hydroxyapatite powders are produced.

The present invention relates to a method for producing an antibacterial photocatalytic ceramic that comprises: making available amorphous Ti; making available a biomimetic material or a biomaterial based on calcium phosphate; functionalizing said biomimetic material or said biomaterial based on calcium phosphate, with said amorphous Ti, obtaining a functionalized and oriented composite; adding said functionalized composite to a ceramic mixture, and/or applying said functionalized composite on a ceramic semi-finished product, where ceramic semi-finished product means the ceramic material before baking; applying said functionalized composite on a ceramic semi-finished product; baking at a temperature between 600 and 1400 C., preferably between 900 and 1300 C., for a time that varies from 20 to 500 minutes, obtaining an antibacterial photocatalytic ceramic.

The present invention further relates to a photocatalytic ceramic material that comprises a biomimetic material having a nanostructured hierarchical structure with macro and micro cavities, within which TiO.sub.2 is included in the crystalline form of rutile, and tiles, sanitary ware and tableware comprising same.