An inorganic porous carrier that can be used to increase the purity of nucleic acid in a production thereof, and that comprises a linker of formula (1), wherein a Survival Bone Rate (SBR) value is 5.0% or more. In the formula (1), a bond * represents a linkage of an inorganic porous substance to the oxygen atom of a silanol group; n is an integer of 1 etc.; R represents independently of each other an alkyl group containing 3 to 10 carbon atoms which may have a substituent such as an alkoxy group etc.; and L represents a single bond; an alkylene group of 1 to 20 carbon atoms; or an alkylene group containing 2 to 20 carbon atoms which contains —CH.sub.2-Q-CH.sub.2— group wherein any group Q selected from a group consisting of —O— etc. is inserted into at least one of —CH.sub.2—CH.sub.2— group constituting the alkylene group.

##STR00001##

An inorganic porous carrier having pore distribution where a pore diameter is 0.04 μm or more, and including a linker of formula (1) [where a bond * represents a bond to an oxygen atom of a silanol group in an inorganic porous substance. R.sup.1 and R.sup.2 represent each independently an alkyl group containing 3 to 10 carbon atoms, or a phenyl group. L represents a single bond; an alkylene group containing 1 to 20 carbon atoms; or an alkylene group containing 2 to 20 carbon atoms containing —CH.sub.2-Q-CH.sub.2— group wherein any group Q selected from a group consisting of —O—, —NH—, —NH—CO—, and —NH—CO—NH— is inserted into at least one of —CH.sub.2—CH.sub.2— group constituting the alkylene group. A carbon atom of the methylene group bound to the group Q does not bond to another group Q at the same time.]; and a method for preparing nucleic acids using the same.

##STR00001##

A two-phase bicontinuous silica structure includes a phase containing silica as a main component and an air phase. The silica has a Q4 bond as a chemical bond, a content of molybdenum in the whole amount of the two-phase bicontinuous silica structure is 2.0% by mass or less, and the phase containing silica as a main component is amorphous.

The invention provides a method for producing a heat insulating material composed of a hydrophobic aerogel, and the method includes the steps of: (1) mixing step; (2) hydrolysis step; (3) condensation step; (4) aging step; and (5) drying step. In the method, a siloxane compound, an inorganic gel, and a halogen-free surfactant are mixed and then a sol-gel process is performed to produce the aerogel heat-insulating material without water-washing. The produced heat-insulating material has preferable strength, smooth appearance, and low shrinkage and can overcome the powder-dropping problem. By the provided method, an aerogel heat-insulating board can be produced, or an aerogel cold-resisting and heat-insulating blanket can be produced by mixing with a fiber or a foam material.

The invention provides a method for producing a heat insulating material composed of a hydrophobic aerogel, and the method includes the steps of: (1) mixing step; (2) hydrolysis step; (3) condensation step; (4) aging step; and (5) drying step. In the method, a siloxane compound, an inorganic gel, and a halogen-free surfactant are mixed and then a sol-gel process is performed to produce the aerogel heat-insulating material without water-washing. The produced heat-insulating material has preferable strength, smooth appearance, and low shrinkage and can overcome the powder-dropping problem. By the provided method, an aerogel heat-insulating board can be produced, or an aerogel cold-resisting and heat-insulating blanket can be produced by mixing with a fiber or a foam material.

A hydrophobic treatment method is used in which at least one sheet filled with a gelled silicic acid is tilted at least two degrees with respect to a horizontal direction in a hydrophobizing solution, and the gelled silicic acid is hydrophobized. A manufacturing method for a sheet-like member is also used. The manufacturing method includes: a sol preparing step of adjusting the pH of a water glass aqueous solution to obtain a sol solution of silicic acid; an adding step of adding the sol solution to a fiber; a gel step of polymerizing and gelling the sol solution; a hydrophobic treatment step of hydrophobizing the gel with the hydrophobic treatment method; and a drying step of drying the hydrophobized gel.

A hydrophobic treatment method is used in which at least one sheet filled with a gelled silicic acid is tilted at least two degrees with respect to a horizontal direction in a hydrophobizing solution, and the gelled silicic acid is hydrophobized. A manufacturing method for a sheet-like member is also used. The manufacturing method includes: a sol preparing step of adjusting the pH of a water glass aqueous solution to obtain a sol solution of silicic acid; an adding step of adding the sol solution to a fiber; a gel step of polymerizing and gelling the sol solution; a hydrophobic treatment step of hydrophobizing the gel with the hydrophobic treatment method; and a drying step of drying the hydrophobized gel.

Disclosed herein is macroporous controlled porosity silica gel (CPSG) covalently modified with a variety of moieties (e.g., moieties suitable for oligonucleotide synthesis comprising a spacer, a linker and a nucleoside, chromophore, ligand or bioconjugation linker, or a spacer and a universal linker). Also disclosed herein are methods of making the covalently-modified, macroporous CPSG, and methods of using the covalently-modified, macroporous CPSG to synthesize oligonucleotides.

Disclosed herein is macroporous controlled porosity silica gel (CPSG) covalently modified with a variety of moieties (e.g., moieties suitable for oligonucleotide synthesis comprising a spacer, a linker and a nucleoside, chromophore, ligand or bioconjugation linker, or a spacer and a universal linker). Also disclosed herein are methods of making the covalently-modified, macroporous CPSG, and methods of using the covalently-modified, macroporous CPSG to synthesize oligonucleotides.

Disclosed are an aerogel blanket production method and an aerogel blanket produced thereby, the aerogel blanket production method including steps of: preparing a blanket; preparing a liquid raw material for aerogel formation with which the blanket is to be impregnated; impregnating the blanket with the liquid raw material; and gelling the impregnated liquid raw material to form aerogel, wherein a step of performing pre-processing on the blanket before the gelling of the liquid raw material is completed. The step of performing pre-processing may be performed after the step of preparing the blanket but before impregnating with the liquid raw material, or may be performed when the impregnated liquid raw material is in a flowable semi-liquid state before the liquid raw material is not completely converted into aerogel.