Provided is a method for producing (alkyl)arene compounds represented by Formulae 3-1, 3-2, and 3-3 by the Friedel-Crafts alkylation reaction of alkyl halide compounds and arene compounds using organic phosphine compounds as a catalyst.

##STR00001##

Provided is a method for producing (alkyl)arene compounds represented by Formulae 3-1, 3-2, and 3-3 by the Friedel-Crafts alkylation reaction of alkyl halide compounds and arene compounds using organic phosphine compounds as a catalyst.

##STR00001##

An alkylation process is described. The alkylation process includes contacting a feed comprising a paraffin or an aromatic with an olefin feed in the presence of a liquid Lewis acid catalyst in an alkylation reaction zone under alkylation conditions to form a reaction mixture comprising alkylation products and the liquid Lewis acid catalyst. The liquid Lewis acid catalyst is the liquid reaction product of a donor molecule and a metal halide. The alkylation products are separated from the liquid Lewis acid catalyst and recovered.

An alkylation process is described. The alkylation process includes contacting a feed comprising a paraffin or an aromatic with an olefin feed in the presence of a liquid Lewis acid catalyst in an alkylation reaction zone under alkylation conditions to form a reaction mixture comprising alkylation products and the liquid Lewis acid catalyst. The liquid Lewis acid catalyst is the liquid reaction product of a donor molecule and a metal halide. The alkylation products are separated from the liquid Lewis acid catalyst and recovered.

Provided are compounds that target the nucleotide-binding oligomerization domain, leucine rich repeat containing X1 (NLRX1) pathway. The compounds can be used to treat multiple conditions, including chronic and/or inflammatory gastrointestinal diseases, cancers, and infectious diseases.

The disclosure provides Group 6 complexes, which, in some embodiments, are useful for catalyzing olefin metathesis reactions. In some embodiments, the compounds are compounds of the following formula:

##STR00001##

wherein: M is a Group 6 metal atom; X is an oxygen atom, NR.sup.5, NN(R.sup.5)(R.sup.5) or NOR.sup.5, R.sup.5 and R.sup.5 independently being various substituents, such as aryl or heteroaryl, each optionally substituted; n is 0 or 1; R.sup.z is a neutral ligand; R.sup.1 is hydrogen or an organic substituent; R.sup.2 is an aryl or heteroaryl group, each optionally substituted; R.sup.3 is an anionic ligand; and R.sup.4 is an anionic ligand, such as a pyrrolide, a pyrazolide, an imidazolide, an indolide, an azaindolide, or an indazolide, each optionally substituted.

The disclosure provides Group 6 complexes, which, in some embodiments, are useful for catalyzing olefin metathesis reactions. In some embodiments, the compounds are compounds of the following formula:

##STR00001##

wherein: M is a Group 6 metal atom; X is an oxygen atom, NR.sup.5, NN(R.sup.5)(R.sup.5) or NOR.sup.5, R.sup.5 and R.sup.5 independently being various substituents, such as aryl or heteroaryl, each optionally substituted; n is 0 or 1; R.sup.z is a neutral ligand; R.sup.1 is hydrogen or an organic substituent; R.sup.2 is an aryl or heteroaryl group, each optionally substituted; R.sup.3 is an anionic ligand; and R.sup.4 is an anionic ligand, such as a pyrrolide, a pyrazolide, an imidazolide, an indolide, an azaindolide, or an indazolide, each optionally substituted.

The disclosure provides Group 6 complexes, which, in some embodiments, are useful for catalyzing olefin metathesis reactions. In some embodiments, the compounds are compounds of the following formula: ##STR00001## wherein: M is a Group 6 metal atom; X is an oxygen atom, ?NR.sup.5, ?NN(R.sup.5)(R.sup.5) or ?NOR.sup.5, R.sup.5 and R.sup.5 independently being various substituents, such as aryl or heteroaryl, each optionally substituted; n is 0 or 1; R.sup.z is a neutral ligand; R.sup.1 is hydrogen or an organic substituent; R.sup.2 is an aryl or heteroaryl group, each optionally substituted; R.sup.3 is an anionic ligand; and R.sup.4 is an anionic ligand, such as a pyrrolide, a pyrazolide, an imidazolide, an indolide, an azaindolide, or an indazolide, each optionally substituted.

The disclosure provides Group 6 complexes, which, in some embodiments, are useful for catalyzing olefin metathesis reactions. In some embodiments, the compounds are compounds of the following formula: ##STR00001## wherein: M is a Group 6 metal atom; X is an oxygen atom, ?NR.sup.5, ?NN(R.sup.5)(R.sup.5) or ?NOR.sup.5, R.sup.5 and R.sup.5 independently being various substituents, such as aryl or heteroaryl, each optionally substituted; n is 0 or 1; R.sup.z is a neutral ligand; R.sup.1 is hydrogen or an organic substituent; R.sup.2 is an aryl or heteroaryl group, each optionally substituted; R.sup.3 is an anionic ligand; and R.sup.4 is an anionic ligand, such as a pyrrolide, a pyrazolide, an imidazolide, an indolide, an azaindolide, or an indazolide, each optionally substituted.

An alkylation process is described. The alkylation process includes contacting a feed comprising a paraffin or an aromatic with an olefin feed in the presence of a liquid Lewis acid catalyst in an alkylation reaction zone under alkylation conditions to form a reaction mixture comprising alkylation products and the liquid Lewis acid catalyst. The liquid Lewis acid catalyst is the liquid reaction product of a donor molecule and a metal halide. The alkylation products are separated from the liquid Lewis acid catalyst and recovered.