Embodiments of the invention include methods of treating, preventing, and/or reduce the risk or severity of a condition selected from the group consisting of muscle wasting, muscle weakness, cachexia, and a combination thereof in an individual in need thereof. In some embodiments, particular small molecules are employed for treatment, prevention, and/or reduction in the risk of muscle wasting. In at least particular cases, the small molecules are inhibitors of STAT3.

The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.

The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.

The present invention provides a compound represented by formula (I), a pharmaceutically acceptable salt thereof or a solvate thereof. ##STR00001##
(In the formula, each of A and Z independently represents CO, SO or SO.sub.2; each of X and Y independently represents S or O; each of R.sup.1-R.sup.4 independently represents a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group or a halogen group; each R.sup.5 independently represents an alkyl group, an alkenyl group, an alkynyl group or a halogen group; and n represents an integer of 0-4.) This compound is capable of specifically binding to an AMPA receptor, and shows extremely high brain uptake.

The present invention provides a compound represented by formula (I), a pharmaceutically acceptable salt thereof or a solvate thereof. ##STR00001##
(In the formula, each of A and Z independently represents CO, SO or SO.sub.2; each of X and Y independently represents S or O; each of R.sup.1-R.sup.4 independently represents a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group or a halogen group; each R.sup.5 independently represents an alkyl group, an alkenyl group, an alkynyl group or a halogen group; and n represents an integer of 0-4.) This compound is capable of specifically binding to an AMPA receptor, and shows extremely high brain uptake.

The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.

The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.

The present invention provides a process for preparation of Vortioxetine hydrobromide (I). The present invention also relates to the novel intermediate and its use in preparation of vortioxetine hydrobromide (I).

##STR00001##

The present invention provides a compound represented by formula (I), a pharmaceutically acceptable salt thereof or a solvate thereof.

##STR00001##

(In the formula, each of A and Z independently represents CO, SO or SO.sub.2; each of X and Y independently represents S or O; each of R.sup.1-R.sup.4 independently represents a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group or a halogen group; each R.sup.5 independently represents an alkyl group, an alkenyl group, an alkynyl group or a halogen group; and n represents an integer of 0-4.) This compound is capable of specifically binding to an AMPA receptor, and shows extremely high brain uptake.

The present invention provides a compound represented by formula (I), a pharmaceutically acceptable salt thereof or a solvate thereof.

##STR00001##

(In the formula, each of A and Z independently represents CO, SO or SO.sub.2; each of X and Y independently represents S or O; each of R.sup.1-R.sup.4 independently represents a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group or a halogen group; each R.sup.5 independently represents an alkyl group, an alkenyl group, an alkynyl group or a halogen group; and n represents an integer of 0-4.) This compound is capable of specifically binding to an AMPA receptor, and shows extremely high brain uptake.