This disclosure relates to aryl amidines of Formula I and their use as fungicides.

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This disclosure relates to aryl amidines of Formula I and their use as fungicides.

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The method for producing a polythiol compound includes reacting 2-mercaptoethanol having a water content of 3000 ppm or less on a mass basis, with epihalohydrin to obtain a halide represented by the formula (1), wherein X represents a halogen atom; and obtaining at least one polythiol compound selected from the group consisting of a polythiol compound represented by the formula (4), a polythiol compound represented by the formula (5), a polythiol compound represented by the formula (6), and a polythiol compound represented by the formula (7). ##STR00001##

The method for producing a polythiol compound includes reacting 2-mercaptoethanol having a water content of 3000 ppm or less on a mass basis, with epihalohydrin to obtain a halide represented by the formula (1), wherein X represents a halogen atom; and obtaining at least one polythiol compound selected from the group consisting of a polythiol compound represented by the formula (4), a polythiol compound represented by the formula (5), a polythiol compound represented by the formula (6), and a polythiol compound represented by the formula (7). ##STR00001##

A corrosion inhibitor for a soft water circulation heating and cooling system, wherein the corrosion inhibitor is pentapentanol core hyperbranched macromolecule functionalized by isothiourea and carboxyl, which has a chemical formula of C.sub.5H.sub.7O.sub.5{COC(CH.sub.3)[CH.sub.2OCOCH.sub.2CH(COOH)SC(NH)NH.sub.2].sub.2}.sub.5. The corrosion inhibitor provided by the present invention is non-phosphorus, biodegradable, non-toxic, low in cost and has good corrosion inhibition effect. Moreover, it has excellent corrosion inhibition performance for circulating heating and cooling systems using soft water as the water source, and can significantly improve the reuse rate of circulating water. The present invention also provides a preparation method of the corrosion inhibitor, which is simple, easy to obtain raw materials and easy to industrialize.

A corrosion inhibitor for a soft water circulation heating and cooling system, wherein the corrosion inhibitor is pentapentanol core hyperbranched macromolecule functionalized by isothiourea and carboxyl, which has a chemical formula of C.sub.5H.sub.7O.sub.5{COC(CH.sub.3)[CH.sub.2OCOCH.sub.2CH(COOH)SC(NH)NH.sub.2].sub.2}.sub.5. The corrosion inhibitor provided by the present invention is non-phosphorus, biodegradable, non-toxic, low in cost and has good corrosion inhibition effect. Moreover, it has excellent corrosion inhibition performance for circulating heating and cooling systems using soft water as the water source, and can significantly improve the reuse rate of circulating water. The present invention also provides a preparation method of the corrosion inhibitor, which is simple, easy to obtain raw materials and easy to industrialize.

A method for producing a polythiol compound includes reacting a polyol compound with thiourea in which a content of ammonium thiocyanate is 0.05% by mass or less to obtain an isothiuronium salt.

Disclosed are ROS-sensitive NOS inhibitors, as well as methods of making and using the same.

Disclosed are ROS-sensitive NOS inhibitors, as well as methods of making and using the same.

A compound of formula (I) given below or a pharmaceutically acceptable salt of the compound is useful as an IDO/TDO inhibitor. Thus, the compound of formula (I) or the pharmaceutically acceptable salt of the compound can be used as, for example, a therapeutic agent for a disease or a disorder selected from tumor, infectious disease, neurodegenerative disorder, cataract, organ transplant rejection, autoimmune disease, postoperative cognitive impairment, and disease related to women's reproductive health [in the following formula (I), ring A represents an aromatic ring, an aliphatic ring, a heterocyclic ring, or a condensed ring of two or more rings selected from an aromatic ring, an aliphatic ring and a heterocyclic ring; X, R.sup.1 and R.sup.2 represent a substituent on a ring atom constituting ring A; m represents an integer of 0 to 6; X represents, for example, a halogen atom; and R.sup.1 and R.sup.2 are the same or different and are selected from, for example, the group consisting of groups of formula (a) or formula (b); and in the following formula (a) and formula (b), Y is selected from the group consisting of O, S, and Se, Z is selected from the group consisting of O, S, and Se, n represents an integer of 1 to 8, r represents an integer of 1 to 8, s represents an integer of 1 to 8, R.sup.4 represents, for example, C(NH)HN.sub.2, and R.sup.6 represents, for example, a substituted or unsubstituted aryl group].

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