This disclosure relates to picolinamides of Formula I and their use as fungicides. ##STR00001##

This disclosure relates to picolinamides of Formula I and their use as fungicides. ##STR00001##

A plant disease control agent which contains a compound represented by formula (1) as an active ingredient.

##STR00001##

The present invention relates to a A copper plating composition, comprising a metal ion supply source, an electrolyte, and a leveling agent comprising a thioamide compound that comprises at least one of a homocyclic aromatic ring and a heterocyclic aromatic ring. Excellently smooth plated surfaces with minimized defects can be obtained when a feature formed on a substrate are plated by using the copper plating composition.

The present invention relates to a A copper plating composition, comprising a metal ion supply source, an electrolyte, and a leveling agent comprising a thioamide compound that comprises at least one of a homocyclic aromatic ring and a heterocyclic aromatic ring. Excellently smooth plated surfaces with minimized defects can be obtained when a feature formed on a substrate are plated by using the copper plating composition.

Identification and evaluation of a set of first-in-class potent inhibitors targeting a new cancer target, Grb2-associated binder-1 (GAB1), which integrates signals from different signaling pathways and is frequently over-expressed in cancer cells. Intensive computational modeling is utilized to understand the structure of the GAB1 pleckstrin homology (PH) domain and screened five million compounds. Upon biological evaluation, several inhibitors were found that induced large conformational changes of the target structure exhibited strong selective binding to GAB1 PH domain. Particularly, these inhibitors demonstrated potent and tumor-specific cytotoxicity in breast cancer cells. This targeting GAB1 signaling may be used for cancer therapy, especially for triple negative breast cancer patients.

Identification and evaluation of a set of first-in-class potent inhibitors targeting a new cancer target, Grb2-associated binder-1 (GAB1), which integrates signals from different signaling pathways and is frequently over-expressed in cancer cells. Intensive computational modeling is utilized to understand the structure of the GAB1 pleckstrin homology (PH) domain and screened five million compounds. Upon biological evaluation, several inhibitors were found that induced large conformational changes of the target structure exhibited strong selective binding to GAB1 PH domain. Particularly, these inhibitors demonstrated potent and tumor-specific cytotoxicity in breast cancer cells. This targeting GAB1 signaling may be used for cancer therapy, especially for triple negative breast cancer patients.

This disclosure relates to picolinamides of Formula I and their use as fungicides.

##STR00001##

The present invention relates to 4-substituted amidine derivatives of the general formula (I), wherein A.sub.1-A.sub.4, D, L, Q, R.sup.7, R.sup.7 and integer's v and w have the meanings as defined in description. The invention further relates to methods for their preparation and use of said compounds to fight undesired phytopathogenic microorganisms, and agents for said purpose, comprising said amidine derivatives, all according to the invention. This invention further relates to a method for controlling undesired phytopathogenic microorganisms by application of said 4-substituted amidine derivatives of general formula (I) to such undesired microorganisms and/or to their habitat, according to the invention.

##STR00001##

The present invention relates to compounds of formula I

##STR00001##

wherein the variables are defined as given in the description and claims. The invention further relates to uses and composition for compounds of formula I.