The present invention relates to novel heterocyclic compounds, to processes for preparation thereof and to the use thereof for controlling animal pests, which include arthropods and especially insects and acarids.

The present invention relates to novel heterocyclic compounds, to processes for preparation thereof and to the use thereof for controlling animal pests, which include arthropods and especially insects and acarids.

The invention relates to novel compounds of the formula (I)

##STR00001##

in which R.sup.1, R.sup.2, R.sup.3, n, V.sup.1, V.sup.2, W, X and Y have the meanings given in the description, a plurality of processes and intermediates for their preparation and their use as acaricides and/or insecticides and/or nematicides for controlling animal pests, for example in crop protection or in the field of animal health.

The invention relates to novel compounds of the formula (I)

##STR00001##

in which R.sup.1, R.sup.2, R.sup.3, n, V.sup.1, V.sup.2, W, X and Y have the meanings given in the description, a plurality of processes and intermediates for their preparation and their use as acaricides and/or insecticides and/or nematicides for controlling animal pests, for example in crop protection or in the field of animal health.

The compounds are of the class of 5-fluorouracil derived acetal and hemiaminal ether compounds, useful in treating liver diseases and various types of cancer. The following formulas are representative of the class of compounds provided herein: ##STR00001##

The compounds are of the class of 5-fluorouracil derived acetal and hemiaminal ether compounds, useful in treating liver diseases and various types of cancer. The following formulas are representative of the class of compounds provided herein: ##STR00001##

Provided is a method for producing an orotic acid derivative, the method comprising a condensation step of performing, under a basic condition, a condensation reaction between an orotic acid halide represented by General Formula (I) and a compound represented by General Formula (II) to generate an orotic acid derivative represented by General Formula (III); and a neutralization crystallization step of precipitating crystals of orotic acid by neutralization crystallization to separate a liquid containing the orotic acid derivative from the crystals of orotic acid, after the condensation step. In General Formula (I), (II), or (III), X is a halogen atom, and A is a group represented by General Formula (A-1) or (A-2). In General Formula (A-1) or (A-2), R.sup.1 is a hydrogen atom or an organic group, and R.sup.2 and R.sup.3 are each independently an organic group. In a case where R.sup.1 is an organic group, R.sup.1 and R.sup.2 may be bonded to each other to form a ring. ##STR00001##

The present invention relates to processes and intermediates for preparing Gonadotropin-Releasing Hormone (GnRH) receptor antagonists of structure (VI); and stereoisomers and pharmaceutically acceptable salts thereof.

The present invention relates to processes and intermediates for preparing Gonadotropin-Releasing Hormone (GnRH) receptor antagonists of structure (VI); and stereoisomers and pharmaceutically acceptable salts thereof.

The invention relates to prodrugs of anti-cancer and anti-autoimmune diseases therapeutic agents, and methods of making and use thereof.