Disclosed is chemical compounds C that are derivatives of norbixin and have tropism for the eye, and are intended to be used in the treatment of eye diseases in mammals, in particular in the context of altering the retinal pigment epithelium and more particularly in the context of age-related macular degeneration (AMD) and Stargardt's disease.

Disclosed is chemical compounds C that are derivatives of norbixin and have tropism for the eye, and are intended to be used in the treatment of eye diseases in mammals, in particular in the context of altering the retinal pigment epithelium and more particularly in the context of age-related macular degeneration (AMD) and Stargardt's disease.

The invention describes membrane permeable creatine prodrugs, pharmaceutical compositions comprising membrane permeable creatine prodrugs, and methods of treating diseases such as ischemia, heart failure, neurodegenerative disorders and genetic disorders affecting the creatine kinase system comprising administering creatine prodrugs or pharmaceutical compositions thereof. The invention also describes treating a genetic disease affecting the creatine kinase system, such as, for example, a creatine transporter disorder or a creatine synthesis disorder comprising administering creatine prodrugs or pharmaceutical compositions thereof.

The invention describes membrane permeable creatine prodrugs, pharmaceutical compositions comprising membrane permeable creatine prodrugs, and methods of treating diseases such as ischemia, heart failure, neurodegenerative disorders and genetic disorders affecting the creatine kinase system comprising administering creatine prodrugs or pharmaceutical compositions thereof. The invention also describes treating a genetic disease affecting the creatine kinase system, such as, for example, a creatine transporter disorder or a creatine synthesis disorder comprising administering creatine prodrugs or pharmaceutical compositions thereof.

The present invention relates to novel di-imine, oxadiazepine and oxadiazine intermediates as key intermediates for preparation of oxadiazine insecticides, the processes of their preparation, purification and use in the preparation of final oxadiazine pesticides, in particular of indoxacarb. Telescopic process of preparation of arthropocidal oxadiazines, in particular indoxacarb is disclosed.

The present invention relates to novel di-imine, oxadiazepine and oxadiazine intermediates as key intermediates for preparation of oxadiazine insecticides, the processes of their preparation, purification and use in the preparation of final oxadiazine pesticides, in particular of indoxacarb. Telescopic process of preparation of arthropocidal oxadiazines, in particular indoxacarb is disclosed.

A process for the preparation of a compound of formula (I):

##STR00001## comprising the reaction of:

R.sup.1C(O)NHNHC(O)R.sup.2, with R.sup.3CH.sub.2CH.sub.2OCH.sub.2CH.sub.2R.sup.4, in the presence of an alcoholic solvent; wherein R.sup.1 and R.sup.2 are independently selected from straight or branched chain alkyl groups, or are bonded to form a 4, 5, or 6-membered heterocycle, and wherein R.sup.3 and R.sup.4 are independently selected from a halide or a sulphate.

A process for the preparation of a compound of formula (I):

##STR00001## comprising the reaction of:

R.sup.1C(O)NHNHC(O)R.sup.2, with R.sup.3CH.sub.2CH.sub.2OCH.sub.2CH.sub.2R.sup.4, in the presence of an alcoholic solvent; wherein R.sup.1 and R.sup.2 are independently selected from straight or branched chain alkyl groups, or are bonded to form a 4, 5, or 6-membered heterocycle, and wherein R.sup.3 and R.sup.4 are independently selected from a halide or a sulphate.