C07D417/12

N-(1,3,4-OXADIAZOL-2-YL)ARYLCARBOXAMIDES OR SALTS THEREOF, PREPARATION METHODS, HERBICIDAL COMPOSITIONS AND USES THEREOF
20230041563 · 2023-02-09 ·

The invention belongs to the technical field of agricultural chemicals, and particularly relates to an N-(1,3,4-oxadiazol-2-yl)arylcarboxamide compound or a salt thereof, a preparation method, a herbicidal composition and a use thereof. The compound is as shown in the following Formula I:

##STR00001## wherein X represents O, S, SO, SO.sub.2 or NR.sub.1; Y represents halogen, cyano, cyanoalkyl, carboxyl, nitro, etc.; or —X—Y represents unsubstituted or substituted five- or six-membered heterocyclyl or heteroaryl; Z represents hydrogen, halogen, cyano, OR.sub.4, -alkyl-OR.sub.4, —O-alkyl-N(R.sub.5).sub.2, etc., M represents hydrogen, OR.sub.6, SR.sub.6, COR.sub.6, COOR.sub.6, CON(R.sub.7).sub.2, etc. The compound has advantages of a low dosage for use, excellent herbicidal activity, and higher crop safety, especially good selectivity for key crops such as rice.

N-(1,3,4-OXADIAZOL-2-YL)ARYLCARBOXAMIDES OR SALTS THEREOF, PREPARATION METHODS, HERBICIDAL COMPOSITIONS AND USES THEREOF
20230041563 · 2023-02-09 ·

The invention belongs to the technical field of agricultural chemicals, and particularly relates to an N-(1,3,4-oxadiazol-2-yl)arylcarboxamide compound or a salt thereof, a preparation method, a herbicidal composition and a use thereof. The compound is as shown in the following Formula I:

##STR00001## wherein X represents O, S, SO, SO.sub.2 or NR.sub.1; Y represents halogen, cyano, cyanoalkyl, carboxyl, nitro, etc.; or —X—Y represents unsubstituted or substituted five- or six-membered heterocyclyl or heteroaryl; Z represents hydrogen, halogen, cyano, OR.sub.4, -alkyl-OR.sub.4, —O-alkyl-N(R.sub.5).sub.2, etc., M represents hydrogen, OR.sub.6, SR.sub.6, COR.sub.6, COOR.sub.6, CON(R.sub.7).sub.2, etc. The compound has advantages of a low dosage for use, excellent herbicidal activity, and higher crop safety, especially good selectivity for key crops such as rice.

SUBSTITUTED ARYLMETHYLUREAS AND HETEROARYLMETHYLUREAS, ANALOGUES THEREOF, AND METHODS USING SAME
20230045421 · 2023-02-09 ·

The present invention includes substituted arylmethyl ureas and heteroarylmethyl-ureas, and compositions comprising the same, that can be used to treat and/or prevent hepatitis B virus (HBV) infections in a patient.

SUBSTITUTED ARYLMETHYLUREAS AND HETEROARYLMETHYLUREAS, ANALOGUES THEREOF, AND METHODS USING SAME
20230045421 · 2023-02-09 ·

The present invention includes substituted arylmethyl ureas and heteroarylmethyl-ureas, and compositions comprising the same, that can be used to treat and/or prevent hepatitis B virus (HBV) infections in a patient.

ALKENE-CONTAINING AMIDE COMPOUND AND APPLICATION THEREOF

An alkene-containing amide compound of formula (I) and agriculturally acceptable salts thereof can be used as herbicides.

##STR00001##

ALKENE-CONTAINING AMIDE COMPOUND AND APPLICATION THEREOF

An alkene-containing amide compound of formula (I) and agriculturally acceptable salts thereof can be used as herbicides.

##STR00001##

Methods and compositions for targeting Tregs using CCR8 inhibitors

The present invention provides compounds of Formula (I) which can be used as CCR8 inhibitors, which can be used as treatment or prevention of cancer using CCR8 inhibitors targeted tumor specific T regulatory cells.

##STR00001##

MODULATORS OF INTEGRATED STRESS RESPONSE PATHWAY

The present disclosure relates generally to therapeutic agents that may be useful as modulators of Integrated Stress Response (ISR) pathway.

MODULATORS OF INTEGRATED STRESS RESPONSE PATHWAY

The present disclosure relates generally to therapeutic agents that may be useful as modulators of Integrated Stress Response (ISR) pathway.

AHR inhibitors and uses thereof

The present invention provides compounds useful as inhibitors of AHR, compositions thereof, and methods of using the same.