Suggested is a plant peptide fraction, obtainable or obtained according to the following steps: (a) providing oat seeds; (b) dehulling and milling said oat seeds; (c) subjecting the seeds of step (b) to an extraction to obtain a first peptide fraction; (d) subjecting the first peptide fraction of step (c) to enzymatic hydrolysis; (e) subjecting the hydrolyzed peptide fraction of step (d) to ultra- and/or nanofiltration to obtain a retentate and a permeate, said permeate enriched in peptide s showing a molecular weight below 2,000 Dalton; and (f) optionally drying the permeate of step (e).

Suggested is a plant peptide fraction, obtainable or obtained according to the following steps: (a) providing oat seeds; (b) dehulling and milling said oat seeds; (c) subjecting the seeds of step (b) to an extraction to obtain a first peptide fraction; (d) subjecting the first peptide fraction of step (c) to enzymatic hydrolysis; (e) subjecting the hydrolyzed peptide fraction of step (d) to ultra- and/or nanofiltration to obtain a retentate and a permeate, said permeate enriched in peptide s showing a molecular weight below 2,000 Dalton; and (f) optionally drying the permeate of step (e).

A cell hydrolysate composition, the composition comprising substantially all protein polypeptides and/or polypeptide fragments derived substantially from all the proteins in a cell from an in vitro cell culture.

A cell hydrolysate composition, the composition comprising substantially all protein polypeptides and/or polypeptide fragments derived substantially from all the proteins in a cell from an in vitro cell culture.

The present disclosure relates to a bio-manufacturing process that enables continuous production of a therapeutic protein with reduced heterogeneity. The bio-manufacturing process disclosed herein utilizes a multi column chromatography system that performs the unit operations of reducing heterogeneity in a therapeutic protein, capturing the therapeutic protein and inactivating viruses, purifying the therapeutic protein, and polishing the purified therapeutic protein. The process disclosed herein can reduce heterogeneity of a therapeutic protein by reducing a proportion of basic isoforms of the therapeutic protein.

The present disclosure relates to a bio-manufacturing process that enables continuous production of a therapeutic protein with reduced heterogeneity. The bio-manufacturing process disclosed herein utilizes a multi column chromatography system that performs the unit operations of reducing heterogeneity in a therapeutic protein, capturing the therapeutic protein and inactivating viruses, purifying the therapeutic protein, and polishing the purified therapeutic protein. The process disclosed herein can reduce heterogeneity of a therapeutic protein by reducing a proportion of basic isoforms of the therapeutic protein.

A method of proteolyzing a protein, including immobilizing a protein in at least one pore of a porous body, and contacting the protein immobilized in the pore and a protease immobilized on a solid surface such that the protease selectively accesses a site of the protein and proteolyzes the protein at the site.

A method of proteolyzing a protein, including immobilizing a protein in at least one pore of a porous body, and contacting the protein immobilized in the pore and a protease immobilized on a solid surface such that the protease selectively accesses a site of the protein and proteolyzes the protein at the site.

A method for obtaining a collagen peptide from a starfish, an elastic liposome containing a starfish-derived collagen peptide, and a cosmetic composition containing the same are disclosed. Methods of using the collagen peptide or the elastic liposome are disclosed. The collagen peptide obtained from a starfish has excellent skin absorption rate and having anti-oxidation and wrinkle-improving activity. Thus, the collagen peptide may replace existing animal collagen to provide collagen with high extraction efficiency.

A method for obtaining a collagen peptide from a starfish, an elastic liposome containing a starfish-derived collagen peptide, and a cosmetic composition containing the same are disclosed. Methods of using the collagen peptide or the elastic liposome are disclosed. The collagen peptide obtained from a starfish has excellent skin absorption rate and having anti-oxidation and wrinkle-improving activity. Thus, the collagen peptide may replace existing animal collagen to provide collagen with high extraction efficiency.