The invention provides compositions and methods for preventing or treating an ischemia-reperfusion injury, such as occurs during acute myocardial infarction and organ transplant in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide or a pharmaceutically acceptable salt thereof, and one or more additional active agents such as cyclosporine.

Tetrapeptides consisting of (I or V)X1-KX2, where X1 can be selected from E, Q or K, and X2 can be selected from M, F, I, W, or V, exhibit diverse bioactivities. They are multi-functional effector molecules to stimulate keratinocytes migration; neutralize the proinflammatory effect of bacterial cell wall components such as lipoteichoic acids of the Gram-positive S. aureus; and induce angiogenesis in cultured human umbilical vein endothelial cells. The downregulation of pro-inflammatory condition was also demonstrated using SOR-300-FT psoriasis skin model for representative peptide. The bioactivity was also supported by gene profiling study upon treatment of normal skin tissues using EPIDERM skin substitutes. The inventive peptides with diverse bioactivities are useful for treating various skin conditions including, but not limited to, acute or chronic wounds, striae distensae, aging skin, hair control, inflammatory skins such as psoriasis, atopic dermatitis and rosacea and for unwanted hair removal or for conditions such as removal of skin tags.

A plant-based fermented product containing a high concentration of gamma-glutamyl peptide, and a method for preparing the plant-based fermented product are disclosed. The plant-based fermented product contains a high concentration of gamma-glutamyl peptide to provide deep and rich flavors, and may be used in sauce such as soy sauce to add Gippeunmat to foods. Further, by using the method for preparing the plant-based fermented product, a plant-based fermented product containing a high concentration of gamma-glutamyl peptide can be prepared in a stable manner.

A plant-based fermented product containing a high concentration of gamma-glutamyl peptide, and a method for preparing the plant-based fermented product are disclosed. The plant-based fermented product contains a high concentration of gamma-glutamyl peptide to provide deep and rich flavors, and may be used in sauce such as soy sauce to add Gippeunmat to foods. Further, by using the method for preparing the plant-based fermented product, a plant-based fermented product containing a high concentration of gamma-glutamyl peptide can be prepared in a stable manner.

The present invention generally relates to compounds that are useful for inhibiting one or more trypsin-like S1 serine proteases, HGFA, matriptase, hepsin, KLK5 and/or TMPRSS2 as well as cysteine proteases including trypsin-like cysteine proteases (e.g. Cathepsin B). The present invention also relates to various methods of using the inhibitor compounds to treat or prevent viral infections, including those caused by coronaviruses and influenza, conditions associated with KLK5, various malignancies, pre-malignant conditions, and cancer.