An actinic ray-sensitive or radiation-sensitive resin composition includes a salt including a sulfonium cation having an aryl group substituted with an acid-decomposable group-containing group and having at least three fluorine atoms; and a resin having a polarity that increases through decomposition by an action of an acid, in which the acid-decomposable group-containing group includes a group having a polarity that increases through decomposition by an action of an acid, and the acid-decomposable group-containing group includes no fluorine atom.

An actinic ray-sensitive or radiation-sensitive resin composition includes a salt including a sulfonium cation having an aryl group substituted with an acid-decomposable group-containing group and having at least three fluorine atoms; and a resin having a polarity that increases through decomposition by an action of an acid, in which the acid-decomposable group-containing group includes a group having a polarity that increases through decomposition by an action of an acid, and the acid-decomposable group-containing group includes no fluorine atom.

A self-healing polymer network containing a physical crosslinking agent, a composition therefor, and an optical element comprising the same is provided. The self-healing polymer network comprises a polymer derived from monomers including self-healing monomers each having a first polymerizable functional group and at least one of urethane, urea, or amide group chemically linked to the first polymerizable functional group, wherein the polymer has a backbone formed by polymerizing the first polymerizable functional groups of the self-healing monomers and a plurality of side groups each having at least one of urethane, urea, or amide group chemically linked to the backbone. In addition, the self-healing polymer network comprises a physical crosslinking agent which is an alcohol mixture having at least two of monool, diol, triol, and tetraol or the higher polyol and crosslinking the polymer by physically crosslinking the urethane, urea, or amide group of the side groups.

A self-healing polymer network containing a physical crosslinking agent, a composition therefor, and an optical element comprising the same is provided. The self-healing polymer network comprises a polymer derived from monomers including self-healing monomers each having a first polymerizable functional group and at least one of urethane, urea, or amide group chemically linked to the first polymerizable functional group, wherein the polymer has a backbone formed by polymerizing the first polymerizable functional groups of the self-healing monomers and a plurality of side groups each having at least one of urethane, urea, or amide group chemically linked to the backbone. In addition, the self-healing polymer network comprises a physical crosslinking agent which is an alcohol mixture having at least two of monool, diol, triol, and tetraol or the higher polyol and crosslinking the polymer by physically crosslinking the urethane, urea, or amide group of the side groups.

A self-healing polymer network containing a physical crosslinking agent, a composition therefor, and an optical element comprising the same is provided. The self-healing polymer network comprises a polymer derived from monomers including self-healing monomers each having a first polymerizable functional group and at least one of urethane, urea, or amide group chemically linked to the first polymerizable functional group, wherein the polymer has a backbone formed by polymerizing the first polymerizable functional groups of the self-healing monomers and a plurality of side groups each having at least one of urethane, urea, or amide group chemically linked to the backbone. In addition, the self-healing polymer network comprises a physical crosslinking agent which is an alcohol mixture having at least two of monool, diol, triol, and tetraol or the higher polyol and crosslinking the polymer by physically crosslinking the urethane, urea, or amide group of the side groups.

Provided herein are aqueous dispersions. The aqueous dispersions can comprise a first copolymer derived from one or more ethylenically unsaturated monomers, and a second carboxy-functional copolymer derived from one or more carboxylic acid-containing monomers. The aqueous dispersions can be used to prepare low- or zero-VOC aqueous coating compositions that possess desirable properties, including good block resistance and scrub resistance. Coatings and coating formulations comprising the aqueous dispersion, as well as methods of making and using the same are also provided.

Provided herein are aqueous dispersions. The aqueous dispersions can comprise a first copolymer derived from one or more ethylenically unsaturated monomers, and a second carboxy-functional copolymer derived from one or more carboxylic acid-containing monomers. The aqueous dispersions can be used to prepare low- or zero-VOC aqueous coating compositions that possess desirable properties, including good block resistance and scrub resistance. Coatings and coating formulations comprising the aqueous dispersion, as well as methods of making and using the same are also provided.

To provide a copolymer including: a structural unit represented by the following General Formula (1) where X represents a hydrogen atom or a cation; a structural unit expressed by the following Structural Formula (1); and a structural unit represented by the following General Formula (2) where R is a hydrogen atom or a methyl group, L is a single bond or —(CH.sub.2).sub.n—O—CO— where n is an integer in a range of from 2 through 18, and a carbonyl carbon atom in the —(CH.sub.2).sub.n—O—CO— is bound to naphthyl.

##STR00001##

A copolymer including a structural unit represented by General Formula (1) below, and a structural unit represented by General Formula (2) below,

##STR00001##

where, in General Formula (1), R.sup.1 is a hydrogen atom or a methyl group, L.sup.1 is an alkylene group having 2 or greater carbon atoms but 5 or less carbon atoms, and X is a hydrogen atom or a cation,

##STR00002##

where, in General Formula (2), R.sup.2 is a hydrogen atom or a methyl group and L.sup.2 is an alkylene group having 2 or greater carbon atoms but 18 or less carbon atoms.

One aspect of the invention provides polymer conjugated MetAP2 inhibitors. While not being bound by any particular theory, it is believed that coupling the MetAP2 inhibitory core via the linkers described herein provides compounds with superior efficacy to the parent small molecules and superior pharmacokinetic profiles. In one aspect of the invention, the polymer conjugated MetAP2 inhibitors are useful in methods of treating disease, comprising administering to a subject in need thereof a therapeutically effective amount of a polymer conjugated MetAP2 inhibitor.